American Journal of Ophthalmology
Volume 140, Issue 5 , Pages 952-954, November 2005

Management of Severe Hypotony with Intravitreal Injection of Viscoelastic

  • Gian Marco Tosi, MD

      Affiliations

    • Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York USA
    • Department of Ophthalmology and Neurosurgery, University of Siena, Siena, Italy.
    • ,
  • William Schiff, MD

      Affiliations

    • Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York USA
    • ,
  • Gaetano Barile, MD

      Affiliations

    • Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York USA
    • ,
  • Norihiko Yoshida, MD

      Affiliations

    • Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York USA
    • ,
  • Stanley Chang, MD

      Affiliations

    • Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York USA
    • Corresponding Author InformationInquiries to Stanley Chang, MD, Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, 635 West 165th St, New York, NY10032; fax: 212-305-5962

Accepted 1 June 2005. published online 09 September 2005.

Purpose

To investigate the effect of an intravitreal injection of sodium hyaluronate 1.4% and 2.3% in the treatment of hypotony.

Design

Interventional case series.

Methods

Intravitreal injection of sodium hyaluronate 1.4% was performed to treat persistent hypotony in three eyes after the successful repair of retinal detachment and in one eye with uveitis. Injection of sodium hyaluronate 2.3% was performed in one eye after the successful repair of retinal detachment with removal of silicone oil.

Results

At the last follow-up examination (2-16 months), intraocular pressure increased to at least 5 mm Hg (5-14 mm Hg) in all eyes that had been injected with sodium hyaluronate. Intraocular pressure increased to 38 mm Hg in the eye that had been injected with sodium hyaluronate 2.3% on postoperative day 1 and was 10 mm Hg at three months. Vision improved in all patients.

Conclusion

Intraocular injection of sodium hyaluronate 1.4 and 2.3% appears to be efficacious in reversing hypotony in some eyes. Functional and structural findings can also improve.

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 Pharmacia donated the viscoelastic used. Pharmacia had no involvement in any of the following: design or conduct of the study; collection, management, analysis or interpretation of data; preparation, review or approval of the manuscript.

PII: S0002-9394(05)00703-8

doi:10.1016/j.ajo.2005.06.019

American Journal of Ophthalmology
Volume 140, Issue 5 , Pages 952-954, November 2005

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