American Journal of Ophthalmology
Volume 133, Issue 3 , Pages 333-336 , March 2002

Pupillary response to four concentrations of pilocarpine in normal subjects: application to testing for adie tonic pupil

  • Jacqueline A Leavitt, MD

      Affiliations

    • Corresponding Author InformationReprint requests to Jacqueline A. Leavitt, MD, Department of Ophthalmology, Mayo Clinic, Rochester, 200 First Street SW, Rochester, MN, 55905 USA; fax: 507-284-4612
    • Department of Ophthalmology (J.A.L., L.L.W., R.F.B.), Mayo Clinic, Rochester, Minnesota, USA
    • ,
  • Laura L Wayman, MD

      Affiliations

    • Department of Ophthalmology (J.A.L., L.L.W., R.F.B.), Mayo Clinic, Rochester, Minnesota, USA
    • ,
  • David O Hodge, MS

      Affiliations

    • Section of Biostatistics (D.O.H.), Mayo Clinic, Rochester, Minnesota, USA
    • ,
  • Richard F Brubaker, MD

      Affiliations

    • Department of Ophthalmology (J.A.L., L.L.W., R.F.B.), Mayo Clinic, Rochester, Minnesota, USA

,Accepted 12 December 2001.

References 

  1. Newsome DA, Loewenfeld IE. Pilocarpine reexamined. Surv Ophthalmol. 1974;18:399–424
  2. Pilley SFJ, Thompson HS. Cholinergic supersensitivity in Adie’s Syndrome (pilocarpine versus mecholyl). (abstract) Am J Ophthalmol. 1975;80:955
  3. Cohen DN, Zakov ZN. The diagnosis of Adie’s pupil using 0.0625% pilocarpine solution. Am J Ophthalmol. 1975;79:883–885
  4. Younge BR, Buski ZJ. Tonic pupil (a simple screening test). Canad J Ophthal. 1976;11:295–299
  5. Thompson HS. Adie’s Syndrome. Some new observations. Trans Am Ophthalmol Soc. 1977;75:587–626
  6. Ramsay DA. Dilute solutions of phenylephrine and pilocarpine in the diagnosis of disordered autonomic innervation of the iris. J Neurolog Sci. 1986;73:125–134
  7. Jacobson DM. Pupillary responses to dilute pilocarpine in preganglionic 3rd nerve disorders. Neurology. 1990;40:804–808
  8. McLaren JW, Fjerstad WH, Ness AB, Graham MD, Brubaker RF. New video pupillometer. Opt Eng. 1995;34:676–683
  9. FitzSimon JS, Waring SC, Kokmen E, McLaren JW, Brubaker RF. Response of the pupil to tropicamide is not a reliable test for Alzheimer disease. Arch Neurol. 1997;54:155–159
  10. McLaren JW, Brubaker RF. A two-dimensional scanning ocular fluorophotometer. Invest Ophthalmol Vis Sci. 1985;26:144–152
  11. Utsumi T. Corneal permeability in patients with tonic pupil. A reevaluation of its cholinergic supersensitivity. J Clin Neuro Ophthalmol. 1990;10:52–55
  12. Drummond PD. The effect of light intensity and dose of dilute pilocarpine eyedrops on pupillary constriction in healthy subjects. Am J Ophthalmol. 1991;112:195–199
  13. Jacobson DM, Olson KA. Influence of pupil size, anisocoria, and ambient light on pilocarpine miosis (implications for supersensitivity testing). Ophthalmology. 1993;100:275–280

☆ Supported in part by Research Grant No. EY00634 and an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York.

PII: S0002-9394(01)01420-9

American Journal of Ophthalmology
Volume 133, Issue 3 , Pages 333-336 , March 2002

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