American Journal of Ophthalmology
Volume 133, Issue 4 , Pages 451-455 , April 2002

Effective treatment of ligneous conjunctivitis with topical plasminogen

  • Patrick Watts (FRCOphth)

      Affiliations

    • Department of Ophthalmology, The Hospital for Sick Children and Toronto Western Hospital, Toronto, Canada (P.W., P.S., E.M., D.R.)
  • ,
  • Palanisamy Suresh (FRCS (Ed))

      Affiliations

    • Department of Ophthalmology, The Hospital for Sick Children and Toronto Western Hospital, Toronto, Canada (P.W., P.S., E.M., D.R.)
  • ,
  • Eedy Mezer, MD

      Affiliations

    • Department of Ophthalmology, The Hospital for Sick Children and Toronto Western Hospital, Toronto, Canada (P.W., P.S., E.M., D.R.)
  • ,
  • Anna Ells (FRCSC)

      Affiliations

    • Department of Ophthalmology, Alberta Children’s Hospital, Calgary, Alberta, Canada (A.E.)
  • ,
  • Manuela Albisetti, MD

      Affiliations

    • Department of Pediatrics, Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada (M.A., V.M., M.A., P.M.)
  • ,
  • Lazlo Bajzar, PhD

      Affiliations

    • Hamilton Civic Hospitals Research Center, Hamilton, Ontario, Canada (L.B.)
  • ,
  • Velma Marzinotto, RN

      Affiliations

    • Department of Pediatrics, Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada (M.A., V.M., M.A., P.M.)
  • ,
  • Maureen Andrew, MD (FRCPC)

      Affiliations

    • Department of Pediatrics, Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada (M.A., V.M., M.A., P.M.)
  • ,
  • Patricia Massicotle, MD (FRCPC)
  • ,
  • David Rootman, MD (FRCSC)

      Affiliations

    • Corresponding Author InformationReprint requests to D. Rootman, MD, FRCSC, Room 009, 7EC, Toronto Western Hospital, Toronto, Ontario, Canada; fax: (416) 603-1993
    • Department of Ophthalmology, The Hospital for Sick Children and Toronto Western Hospital, Toronto, Canada (P.W., P.S., E.M., D.R.)

,Accepted 6 December 2001.

References 

  1. Bateman JB, Pettit T, Isenberg SJ, Simons KB. Ligneous conjunctivitis (an autosomal recessive disorder). J Pediatr Ophthalmol Strabismus. 1986;23:137–140
  2. Cohen SR. Ligneous conjunctivitis (an ophthalmic disease with potentially fatal tracheobronchial obstruction). Laryngeal and tracheobronchial features. Ann Otol Rhinol Laryngol. 1990;99(7, Pt 1):509–512
  3. Cooper TJ, Kazdan JJ, Cutz E. Ligneous conjunctivitis with tracheal obstruction. A case report with light and electron microscopy findings. Can J Ophthalmol. 1979;14:57–62
  4. Newcomer V, Klein A. Ligneous conjunctivitis [proceedings]. Arch Dermatol. 1977;113:511–512
  5. Rubin A, Buck D, MacDonald MR. Ligneous conjunctivitis involving the cervix. Case report. Br J Obstet Gynaecol. 1989;96:1228–1230
  6. Mingers AM, Heimburger N, Zeitler P, Kreth HW, Schuster V. Homozygous type I plasminogen deficiency. Semin Thromb Hemost. 1997;23:259–269
  7. Mingers AM, Philapitsch A, Schwarz HP, Zeitler P, Kreth HW. Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. Semin Thromb Hemost. 1998;24:605–612
  8. Mingers AM, Philapitsch A, Zeitler P, Schuster V, Schwarz HP, Kreth HW. Human homozygous type I plasminogen deficiency and ligneous conjunctivitis. Apmis. 1999;107:62–72
  9. Schuster V, Mingers AM, Seidenspinner S, Nussgens Z, Pukrop T, Kreth HW. Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. Blood. 1997;90:958–966
  10. Schuster V, Seidenspinner S, Muller C, Rempen A. Prenatal diagnosis in a family with severe type I plasminogen deficiency, ligneous conjunctivitis and congenital hydrocephalus. Prenat Diagn. 1999;19:483–487
  11. Hidayat AA, Riddle PJ. Ligneous conjunctivitis. A clinicopathologic study of 17 cases. Ophthalmology. 1987;94:949–959
  12. Ligneous conjunctivitis . Lancet 335. 1990;84:
  13. Francois J, Victoria-Troncoso V. Treatment of ligneous conjunctivitis. Am J Ophthalmol. 1968;65:674–678
  14. Firat T. Ligneous conjunctivitis. Am J Ophthalmol. 1974;78:679–688
  15. De Cock R, Ficker LA, Dart JG, Garner A, Wright P. Topical heparin in the treatment of ligneous conjunctivitis. Ophthalmology. 1995;102:1654–1659
  16. Holland EJ, Chan CC, Kuwabara T, Palestine AG, Rowsey JJ, Nussenblatt RB. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol. 1989;107:160–166
  17. Schott D, Dempfle CE, Beck P, et al.  Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. N Engl J Med. 1998;339:1679–1686
  18. Martinovic E, Ells A. Ligneous conjunctivitis related to a defect in the fibrinolytic system (a case report). Can J Ophthalmol. 2001;36:147–149
  19. Murray JC, Buetow KH, Donovan M, et al.  Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26–6q27. Am J Hum Genet. 1987;40:338–350
  20. Schuster V, Seidenspinner S, Zeitler P, et al.  Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. Blood. 1999;93:3457–3466
  21. Marcus DM, Walton D, Donshik P, Choo L, Newman RA, Albert DM. Ligneous conjunctivitis with ear involvement. Arch Ophthalmol. 1990;108:514–519
  22. Parunovic A, Stefanovic D. (Conjunctivitis lignosa and hydrocephalus [an unusual association of 2 diseases]). Vestn Oftalmol. 1993;109(4):30–31
  23. Chen S, Wishart M, Hiscott P. Ligneous conjunctivitis (a local manifestation of a systemic disorder?). J Aapos. 2000;4:313–315
  24. Tait RC, Walker ID, Conkie JA, Islam SI, McCall F. Isolated familial plasminogen deficiency may not be a risk factor for thrombosis. Thromb Haemost. 1996;76:1004
  25. Lijnen HR, Carmeliet P, Bouche A, et al.  Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen. Blood. 1996;88:870–876
  26. Dempfle CE, Schott D, Niessen KH, Heene DL. Fibrinogen heterogeneity in homozygous plasminogen deficiency type 1 (further evidence that plasmin is not involved in formation of LMW and LMW’- fibrinogen). Thromb Haemost. 1997;77:879–883
  27. Weinstock SM, Kielar RA. Bulbar ligneous conjunctivitis after pterygium removal in an elderly man. Am J Ophthalmol. 1975;79:913–915
  28. Bierly JR, Blandford DL, Weeks JA, Baker RS. Ligneous conjunctivitis as a complication following strabismus surgery. J Pediatr Ophthalmol Strabismus. 1994;31:99–103
  29. Girard LJ, Veselinovic A, Font RL. Ligneous conjunctivitis after pingueculae removal in an adult. Cornea. 1989;8:7–14
  30. Schwartz GS, Holland EJ. Induction of ligneous conjunctivitis by conjunctival surgery. Am J Ophthalmol. 1995;120:253–254
  31. Melikian HE. Treatment of ligneous conjunctivitis. Ann Ophthalmol. 1985;17:763–765
  32. Cohen Tervaert D, Cruysberg JR, Deutman AF, Manschot WA. Ligneous conjunctivitis. Doc Ophthalmol. 1986;64:5–11
  33. Bouchard CS, Belin MW. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis [letter; comment]. Am J Ophthalmol. 1989;108:210–212
  34. Holland EJ, Olsen TW, Ketcham JM, et al.  Topical cyclosporin A in the treatment of anterior segment inflammatory disease. Cornea. 1993;12:413–419

PII: S0002-9394(01)01433-7

American Journal of Ophthalmology
Volume 133, Issue 4 , Pages 451-455 , April 2002