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American Journal of Ophthalmology
Volume 135, Issue 1
, Pages 20-25
, January 2003
Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant
References
- . Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. J Infect Dis. 1992;166:1223–1227
- . Ocular manifestations of HIV infection. N Engl J Med. 1998;339:236–244
- . Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis. J Infect Dis. 1998;177:1176–1181
- . Cytomegalovirus retinitis and resistance (ganciclovir resistance. CMV retinitis and viral resistance group). J Infect Dis. 1998;177:770–773
- . A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature. 1992;358:162–164
- . Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature. 1992;358:160–162
- . Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J Virol. 1994;68:4427–4431
- Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance. J Infect Dis. 1995;171:576–583
- . Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates. J Infect Dis. 1995;172:239–242
- . Detection of ganciclovir resistance mutations and quantitation of cytomegalovirus (CMV) DNA in leukocytes of patients with fatal disseminated CMV disease. J Infect Dis. 1996;173:523–528
- Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. J Virol. 1996;70:1390–1395
- Point mutation in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J Virol. 1992;66:7146–7152
-
A point mutation in the cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphoylmethoxyalkyl derivatives.
Antimicrob Agents Chemother. 1993;37:3719–3725
- . Identification of multiple strains of cytomegalovirus in homosexual men. J Infect Dis. 1989;159:123–126
- . Glycoprotein B subtyping of cytomegalovirus (CMV) in the vitreous of patients with AIDS and CMV retinitis. J Infect Dis. 1998;178:1149–1153
- Intravitreal ganciclovir concentration after intravenous administration in AIDS patients with cytomegalovirus retinitis; implications for therapy. J Infect Dis. 1993;168:1506–1509
- Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients. N Engl J Med. 1989;320:289–293
- Low plasma concentrations achieved with conventional schedules of administration of ganciclovir in patients with AIDS. J Infect Dis. 1996;174:188–190
- . Treatment of CMV retinitis with an intraocular sustained-release ganciclovir implant. A randomized trial. Arch Ophthalmol. 1994;112:1531–1539
- . Antiviral susceptibility testing of cytomegalovirus (criteria for detecting resistance to antivirals). Clin Diagn Virol. 1993;1:179–185
- Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis in the era of potent antiretroviral therapy (Recommendations of the International AIDS Society-USA Panel). Am J Ophthalmol. 1999;127:329–339
- . Treatment of recurrent cytomegalovirus retinitis with the ganciclovir implant. Am J Ophthalmol. 1999;127:276–282
- Use of the ganciclovir implant in the treatment of recurrent cytomegalovirus retinitis. Arch Ophthalmol. 1996;114:815–820
- . Viral sensitivity testing in patients with cytomegaloirus retinitis clinically resistant to foscarnet or ganciclovir. Am J Ophthalmol. 1995;119:587–596
- Phase II dose-ranging trial of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients intolerant of or resistant to ganciclovir (ACTG Protocol 093). AIDS. 1994;8:451–459
-
.
Directed mutagenesis using the polymerase chain reaction.
In:
Ausubel FM, Brent R, Kingston RE editor.
Current protocols in molecular biology. Volume 1:New York: John Wiley & Sons; 1997;
8:5.1–8.5.10
- . High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes. J Infect Dis. 1997;176:69–77
- Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Antimicrob Agents Chemother. 1999;43:1500–1502
- . Prevalence of CMV UL97 resistance mutations in untreated patients with CMV retinitis. J Infect Dis. 2000;182:1234–1238
- . Sensitivities of clinical isolates of human cytomegolovirus to 9-(1,3-dihydroxy-2-propoxymethyl) guanine. J Infect Dis. 1985;152:833–834
- . BW B759U for cytomegalovirus retinitis (intraocular drug penetration). Arch Ophthalmol. 1986;104:1436–1437
- . Ganciclovir-resistant cytomegalovirus clinical isolates (mode of resistance to ganciclovir). Antimicrob Agents Chemother. 1991;35:2191–2197
-
.
Clinical use of ganciclovir for cytomegalovirus infection and the development of drug resistance.
J Acquir Immune Defic Syndr. 1991;4:S42–S46
- A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. Am J Ophthalmol. 1995;120:219–226
☆ This study was supported in part by Research to Prevent Blindness, Inc., New York, New York; Fight for Sight, New York, New York; and the Ralph and Sophie Heintz Lab and Lecture Fund (T.P.M.). Drs. Kuppermann and Martin have served as consultants to Bausch & Lomb/Chiron Vision.
☆☆ InternetAdvance publication at ajo.com Nov 7, 2002.
PII: S0002-9394(02)01758-0
© 2003 Elsevier Science Inc. All rights reserved.
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American Journal of Ophthalmology
Volume 135, Issue 1
, Pages 20-25
, January 2003
