A six-month randomized clinical trial comparing the intraocular pressure-lowering efficacy of bimatoprost and latanoprost in patients with ocular hypertension or glaucoma

Mean (± standard error of the mean [SEM]) change from baseline intraocular pressure (IOP) for all 12 follow-up measurements. The mean IOP reduction from baseline was statistically significantly greater with bimatoprost than with latanoprost at each timepoint (P ≤ .024). Solid bars = bimatoprost; open bars = latanoprost.

Diurnal mean (± standard error of the mean [SEM]) intraocular pressure (IOP) at the 6-month study visit. Open box = latanoprost; solid circle = bimatoprost.

Percentage of patients achieving target intraocular pressure (IOP) at month 6. (Top) 8 am. (Middle) 12 pm. (Bottom) 4 pm. P values in the graph represent between-group comparisons. Target pressure values were also calculated based on the distribution of patients with IOP ≤15 mm Hg, IOP from >15 to ≤18 mm Hg, and IOP >18 mm Hg. This analysis showed a statistically significant difference between treatment groups at 8 am (P = .014), 12 pm (P = .006), and 4 pm (P = .026). Solid bars = bimatoprost; open bars = latanoprost.