To assess indocyanine green angiography (ICGA) as a method for monitoring autograft perfusion after pterygium excision with limbal-conjunctival autograft transplantation (LCAT) and to compare ICGA with anterior segment fluorescein angiography (ASFA).
Design
Nonrandomized prospective interventional case series.
Methods
Twelve eyes of 11 patients with primary pterygium treated by excision and limbal-conjunctival autograft transplantation were studied in a clinical practice. Anterior segment fluorescein angiography and ICGA findings for autograft vascularization after pterygium surgery were compared in 12 eyes of the 11 patients. Graft perfusion was monitored for 1 month with ASFA and ICGA, on days 1,7, and 30 post-surgery.
Results
With ASFA no graft perfusion was observed by postoperative day 30; only five grafts were isofluorescent with some vascularization, while the remaining seven grafts were hypofluorescent without any vascularization. In contrast, ICGA showed that, on postoperative day 1, all 12 grafts were hypofluorescent with multiple hyperfluorescent foci at the graft margin in the late phase and that, by postoperative day 7, 10 grafts were hypofluorescent and appeared to be perfused, originating from the episcleral vascular bed. On day 30, ICGA demonstrated isofluorescent grafts in 10 eyes with some conjunctival and episcleral vascular patterns on the graft itself, including the conjunctiva adjacent to the graft. By this stage, perfusion of the graft was complete.
Conclusion
Indocyanine green angiography is useful for monitoring graft perfusion after LCAT in pterygium surgery. Further studies are needed to identify the implications of graft perfusion for therapy following LCAT in patients with pterygium.
aDepartment of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
Inquiries to Pinar Aydin MD, PhD, Tunali Hilmi Caddesi No: 110/13, Kavaklidere Ankara 06700, Turkey; fax: (+90) 312-466-1512
ABSTRACT