American Journal of Ophthalmology
Volume 136, Issue 4 , Pages 630-639 , October 2003

The course of moderate amblyopia treated with atropine in children: experience of the amblyopia treatment study

  • The Pediatric Eye Disease Investigator Group*

      Affiliations

    • Corresponding Author InformationInquiries to Roy W. Beck, MD, PhD, PEDIG Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    • Corresponding Author InformationInquiries to Roy W. Beck, MD, PhD, PEDIG Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    • pedig@jaeb.org

,Accepted 20 March 2003.

References 

  1. North RV, Kelly ME. A review of the uses and adverse effects of topical administration of atropine. Ophthalmol Physiol Opt. 1987;7:109–114
  2. Simons K, Stein L, Sener EC, Vitale S, Guyton DL. Full-time atropine, intermittent atropine, and optical penalization and binocular outcome in treatment of strabismic amblyopia. Ophthalmology. 1997;104:2143–2155
  3. Pediatric Eye Disease Investigator Group . A randomized trial of atropine vs patching for treatment of moderate amblyopia in children. Arch Ophthalmol. 2002;120:268–278
  4. Pediatric Eye Disease Investigator Group . The clinical profile of moderate amblyopia in children younger than 7 years. Arch Ophthalmol. 2002;120:281–287
  5. Holmes JM, Beck RW, Repka MX, et al.  The amblyopia treatment study visual acuity testing protocol. Arch Ophthalmol. 2001;119:1345–1353
  6. Moke PS, Turpin AH, Beck RW, et al.  Computerized method of visual acuity testing (adaptation of the amblyopia treatment study visual acuity testing protocol). Am J Ophthamol. 2001;132:903–909
  7. Repka MX, Ray JM. The efficacy of optical and pharmacological penalization. Ophthalmology. 1993;100:769–775
  8. Swann AP, Hunter CD. A survey of amblyopia treated by atropine occlusion. Br Orthopt J. 1974;31:65–69
  9. Simons K. Preschool vision screening (rationale, methodology and outcome). Surv Ophthalmol. 1996;41:3–30
  10. Kaye SB, Chen SI, Price G, et al.  Combined optical and atropine penalization for the treatment of strabismic and anisometropic amblyopia. J AAPOS. 2002;6:289–293
  11. Miranda MN. Residual accommodation (A comparison between cyclopentolate 1% and a combination of cyclopentolate 1% and tropicamide 1%). Arch Ophthalmol. 1972;87:515–517
  12. Lovasik JV. Pharmacokinetics of topically applied cyclopentolate HCI and Tropicamide. Am J Optom Physiol Opt. 1986;63:787–803
  13. Ron A, Nawratzki I. Penalization treatment of amblyopia. Metab Ophthalmol. 1978;2:151–153
  14. Ron A, Nawratzki I. Penalization treatment of amblyopia (A follow-up study of two years in older children). J Pediatr Ophthalmol Strabismus. 1982;19:137–139
  15. Foley-Nolan A, McCann A, O’Keefe M. Atropine penalisation versus occlusion as the primary treatment for amblyopia. Br J Ophthalmol. 1997;81:54–57
  16. Wright KW, Guyton DL. A test for predicting the effectiveness of penalization on amblyopia, Acta (XXIV International Congress of Ophthalmology). Philadelphia: J. B. Lippincott; 1983;
  17. von Noorden GK, Milam JB. Penalization in the treatment of amblyopia. Am J Ophthalmol. 1979;88:511–518
  18. North RV, Kelly ME. Atropine occlusion in the treatment of strabismic amblyopia and its effect upon the non-amblyopic eye. Ophthalmol Physiol Opt. 1991;11:113–117
  19. Kennedy RH, Dyer JA, Kennedy MA, et al.  Reducing the progression of myopia with atropine (a long term cohort study of Olmsted County students). Binoc Vis Q. 2000;15:281–304
  20. Brodstein RS, Brodstein DE, Olson RJ, Hunt SC, Williams RR. The treatment of myopia with atropine and bifocals (a long-term prospective study). Ophthalmology. 1984;91:1373–1379
  21. Bedrossian RH. The effect of atropine on myopia. Ophthalmology. 1979;86:713–717

 Supported by a cooperative agreement from the National Eye Institute, EY11751.InternetAdvance publication at ajo.com April 28, 2003.

PII: S0002-9394(03)00458-6

doi: 10.1016/S0002-9394(03)00458-6

American Journal of Ophthalmology
Volume 136, Issue 4 , Pages 630-639 , October 2003