American Journal of Ophthalmology
Volume 137, Issue 2 , Pages 258-264 , February 2004

Photodynamic therapy for age-related macular degeneration in a clinical setting: visual results and angiographic patterns

  • Ruth Axer-Siegel, MD

      Affiliations

    • Department of Ophthalmology, Rabin Medical Center, Beilinson, Petah Tiqva, Israel (R.A.-S., R.E., I.R., M.K., D.W.)
    • Mor Institute for Medical Data, Bnei Brak, Israel (R.A.-S., Y.K., I.R., M.K., E.P., D.W.)
    • Sackler Faculty of Medicine (R.A.-S., Y.K., D.W.), Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationInquiries to Ruth Axer-Siegel, MD, Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49 100, Israel; fax: (+972) 3-921-9084
    • ,
  • Rita Ehrlich, MD

      Affiliations

    • Department of Ophthalmology, Rabin Medical Center, Beilinson, Petah Tiqva, Israel (R.A.-S., R.E., I.R., M.K., D.W.)
    • ,
  • Yuval Yassur, MD

      Affiliations

    • Mor Institute for Medical Data, Bnei Brak, Israel (R.A.-S., Y.K., I.R., M.K., E.P., D.W.)
    • Sackler Faculty of Medicine (R.A.-S., Y.K., D.W.), Tel Aviv University, Tel Aviv, Israel
    • ,
  • Irit Rosenblatt, MD

      Affiliations

    • Department of Ophthalmology, Rabin Medical Center, Beilinson, Petah Tiqva, Israel (R.A.-S., R.E., I.R., M.K., D.W.)
    • Mor Institute for Medical Data, Bnei Brak, Israel (R.A.-S., Y.K., I.R., M.K., E.P., D.W.)
    • ,
  • Michal Kramer, MD

      Affiliations

    • Department of Ophthalmology, Rabin Medical Center, Beilinson, Petah Tiqva, Israel (R.A.-S., R.E., I.R., M.K., D.W.)
    • Mor Institute for Medical Data, Bnei Brak, Israel (R.A.-S., Y.K., I.R., M.K., E.P., D.W.)
    • ,
  • Ethan Priel

      Affiliations

    • Mor Institute for Medical Data, Bnei Brak, Israel (R.A.-S., Y.K., I.R., M.K., E.P., D.W.)
    • ,
  • Yoav Benjamini, PhD

      Affiliations

    • Department of Statistics, Sackler Faculty of Exact Sciences (Y.B.), Tel Aviv University, Tel Aviv, Israel
    • ,
  • Dov Weinberger, MD

      Affiliations

    • Department of Ophthalmology, Rabin Medical Center, Beilinson, Petah Tiqva, Israel (R.A.-S., R.E., I.R., M.K., D.W.)
    • Mor Institute for Medical Data, Bnei Brak, Israel (R.A.-S., Y.K., I.R., M.K., E.P., D.W.)
    • Sackler Faculty of Medicine (R.A.-S., Y.K., D.W.), Tel Aviv University, Tel Aviv, Israel

,Accepted 5 August 2003.

References 

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  5. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group . Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin (one-year results of 2 randomized clinical trials—TAP report 1). Arch Ophthalmol. 1999;117:1329–1345
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  8. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group . Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration (two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization—verteporfin in photodynamic therapy report 2). Am J Ophthalmol. 2001;131:541–560
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  14. Ting TD, Oh M, Cox TA, et al.  Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration. Arch Ophthalmol. 2002;120:731–737
  15. Slakter JS, Yannuzzi LA, Schneider U, et al.  Retinal choroidal anastomoses and occult choroidal neovascularization in age-related macular degeneration. Ophthalmol. 2000;107:742–754
  16. Axer-Siegel R, Bourla D, Priel E, et al.  Angiographic and flow patterns of retinal choroidal anastomoses in age-related macular degeneration with occult chroidal neovascularization. Ophthalmol. 2002;109:1726–1736
  17. Kuhn D, Meunier I, Soubrane G, Coscas G. Imaging of chorioretinal anastomoses in vascularized retinal pigment epithelium detachments. Arch Ophthalmol. 1995;113:1392–1398
  18. Flower RW, Snyder WJ. Expanded hypothesis on the mechanism of photodynamic therapy action on choroidal neovascularization. Retina. 1999;19:365–369
  19. Schmidt-Erfurht U, Laqua H, Scholtzer-Schrehard U, et al.  Histopathological changes following photodynamic therapy in human eyes. Arch Ophthalmol. 2002;6:835–844
  20. Ghazi NG, Jabbour NM, De La Cruz ZC, Green WR. Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy. Retina. 2001;21:478–486
  21. Moshfeghi DM, Kaiser PK, Grossniklaus HE, et al.  Clinicopathologic study after submacular removal of choroidal neovascular membranes treated with verteporfin ocular photodynamic therapy. Am J Ophthalmol. 2003;135:343–350
  22. Schmidt-Erfurth U, Michels S, Barbazetto I, Laqua H. Photodynamic effects on choroidal neovascularization and physiologic choroid. Invest Ophthalmol Vis Sci. 2002;43:830–840
  23. Miller JW, Walsh AW, Kramer M, et al.  Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin. Arch Ophthalmol. 1995;113:810–818
  24. Husain D, Kramer M, Kenney AG, et al.  Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 weeks after treatment. Invest Ophthalmol Vis Sci. 1999;40:2322–2331

☆ Biosketches and/or additional material at www.ajo.com doi:10.1016/j.ajo.2003.08.009Internet Advance publication at ajo.com Sept 10, 2003.

PII: S0002-9394(03)00946-2

doi: 10.1016/j.ajo.2003.08.009

American Journal of Ophthalmology
Volume 137, Issue 2 , Pages 258-264 , February 2004

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