American Journal of Ophthalmology
Volume 137, Issue 2 , Pages 244-249 , February 2004

Influence of intraoperative epithelial defects on outcomes in LASIK for myopia

  • Matthew S Oliva, MD

      Affiliations

    • Department of Ophthalmology, University of Washington Seattle, Washington, USA
    • ,
  • Renato Ambrósio Jr, MD

      Affiliations

    • Department of Ophthalmology, University of Washington Seattle, Washington, USA
    • (M.S.O., R.A., S.E.W.), Department of Ophthalmology, University of São Paulo São Paulo, Brazil
    • (R.A.), Instituto de Olhos Renato Ambrósio Rio de Janeiro, Brazil
    • ,
  • Steven E Wilson, MD

      Affiliations

    • Department of Ophthalmology, University of Washington Seattle, Washington, USA
    • Cole Eye Institute, The Cleveland Clinic Foundation Cleveland, Ohio, USA
    • Corresponding Author InformationInquiries to Steven E. Wilson, MD, Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA

,Accepted 18 August 2003.

References 

  1. Ambrósio R, Wilson SE. Complications of LASIK (etiology, prevention, and treatment). J Refract Surg. 2000;17:350–379
  2. Davidorf JM, Zaldivar R, Oscherow S. Results and complications of laser in situ keratomileusis by experienced surgeons. J Refract Surg. 1998;14:114–122
  3. Smirennaia E, Sheludchenko V, Kourenkova N, Kashnikova O. Management of corneal epithelial defects following LASIK. J Refract Surg. 2001;17:S196–199
  4. Jacobs JM, Taravella MJ. Incidence of intraoperative flap complications in laser in situ keratomileusis. J Cataract Refract Surg. 2002;28:23–28
  5. Walker MB, Wilson SE. Lower intraoperative flap complication rate with the hansatome microkeratome compared to the automated corneal shaper. J Refract Surg. 2000;16:79–82
  6. Tekwani NH, Huang D. Risk factors for intraoperative epithelial defect in laser in-situ keratomileusis. Am J Ophthalmol. 2002;134:311–316
  7. Dastgheib KA, Clinch TE, Mache EE, et al.  Sloughing of corneal epithelium and wound healing complications associated with laser in situ keratomileusis in patients with epithelial basement membrane dystrophy. Am J Ophthalmol. 2000;130:297–303
  8. Bashour M. Risk factors for epithelial erosions in laser in situ keratomileusis. J Cataract Refract Surg. 2002;28:1780–1788
  9. Fraunfelder FW, Rich L. Laser-assisted in situ keratomileusis complication in diabetes mellitus. Cornea. 2002;21:246–248
  10. Ti SE, Tan DTH. Recurrent corneal erosion after laser in situ keratomileusis. Cornea. 2001;20:156–158
  11. Haw WW, Manche EE. Late onset diffuse lamellar keratitis associated with an epithelial defect in six eyes. J Refract Surg. 2000;16:744–748
  12. Wilson SE, Ambrosio R. Sporadic diffuse lamellar keratitis (DLK) after LASIK. Cornea. 2002;21:560–563
  13. Shah MN, Misra M, Wihelmus KR, Koch DD. DLK associated with epithelial defects after LASIK. J Cataract Refract Surg. 2000;26:1312–1318
  14. Castillo A, Diaz-Valle D, Gutierrez AR, et al.  Peripheral melt of flap after laser in situ keratomileusis. J Refract Surg. 1998;16:744–748
  15. Wang M, Maloney RK. Epithelial ingrowth after laser in situ keratomileusis. Am J Ophthalmol. 2000;129:746–751
  16. Asano-Kato N, Toda I, Hori-Komai Y, Takano Y, Tsubota K. Epithelial ingrowth after laser in situ keratomileusis (clinical features and possible mechanisms). Am J Ophthalmol. 2002;134:801–807
  17. Davis E, Hardten D, Lindstrom R. LASIK complications. Int Ophthalmol Clin. 2000;40:73
  18. Spadea L, Fasciani R, Necozione S, Balestrazzi E. Role of the corneal epithelium in refractive changes following LASIK for high myopia. J Refract Surg. 2000;16:133–139
  19. Waring GO. Standard graphs for reporting refractive surgery. J Refract Surg. 2000;16:459–466
  20. Del Pero RA, Gigstad JE, Roberts AD, et al.  A refractive and histopathological study of excimer laser keratectomy in primates. Am J Ophthalmol. 1990;109:419–429
  21. Mohan RR, Hutcheon A, Choi R, et al.  Apoptosis, necrosis, proliferation, and myofibrolast generation in the stroma following LASIK and PRK. Exp Eye Res. 2003;76:71–87
  22. Helena MC, Baerveldt F, Kim WJ, Wilson SE. Keratocyte apoptosis after corneal surgery. Invest Ophthal Vis Sci. 1998;39:276–283
  23. Wilson SE. Stromal—epithelial interactions in the cornea. Prog Retin Eye Res. 1999;8:293–309
  24. Wilson SE. Role of apoptosis in wound healing in the cornea. Cornea. 2000;19S:7–12
  25. Hanna KD, Pouliquen YM, Waring GO, Savoldelli M, Fantes F, Thompson KP. Corneal wound healing in monkeys after repeated excimer laser photorefractive keratectomy. Arch Ophthalmol. 1992;110:1286–1291
  26. Ahee JA, Kaufman SC, Samuel MA, Bogorad D, Wee C. Decreased incidence of epithelial defects during laser in situ keratomileusis using intraoperative nonpreserved carboxymethylcellulose sodium 0.5% solution. J Cataract Refract Surg. 2002;28:1651–1654

☆ Supported in part by U.S. Public Health Service grants EY10056 from National Eye Institute, National Institutes of Health, Bethesda, Maryland, and an unrestricted grant from Research to Prevent Blindness, New York, New York.

PII: S0002-9394(03)01009-2

doi: 10.1016/j.ajo.2003.08.046

American Journal of Ophthalmology
Volume 137, Issue 2 , Pages 244-249 , February 2004

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