American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 401-406, March 2004

Total plasma homocysteine and primary open-angle glaucoma☆

  • Gloria Wang, MD

      Affiliations

    • Departments of Ophthalmology (G.W., F.A.M., R.N.W.), University of California, San Diego, San Diego, California, USA
    • ,
  • Felipe A. Medeiros, MD

      Affiliations

    • Departments of Ophthalmology (G.W., F.A.M., R.N.W.), University of California, San Diego, San Diego, California, USA
    • ,
  • Bruce A. Barshop, MD

      Affiliations

    • Pediatrics (B.A.B.), University of California, San Diego, San Diego, California, USA
    • ,
  • Robert N. Weinreb, MD

      Affiliations

    • Departments of Ophthalmology (G.W., F.A.M., R.N.W.), University of California, San Diego, San Diego, California, USA
    • Corresponding Author InformationInquiries to Robert N. Weinreb, MD, Hamilton Glaucoma Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA

Accepted 12 September 2003.

Abstract 

Purpose

To evaluate total plasma homocysteine (tHcy) levels in patients diagnosed with primary open-angle glaucoma (POAG) and normal subjects.

Design

Case-control study.

Methods

This study involved 55 POAG patients, 16 patients with secondary open-angle glaucoma or angle-closure glaucoma (non-POAG group), and 39 control healthy subjects undergoing ocular surgery. All glaucoma patients had characteristic glaucomatous optic disk damage and visual field loss. Fasting tHcy concentrations of all study participants were determined using high-performance liquid chromatography. Analysis of variance was used to compare homocysteine levels among the three diagnostic groups, and multivariate analysis was conducted to assess the associations between tHcy and diagnostic group, age, gender, smoking status, systemic hypertension, hyperlipidemia, and cardiovascular or cerebrovascular disease.

Results

Mean ± standard deviation of tHcy levels in POAG individuals, non-POAG patients and control subjects was 14.90 ± 6.45 μmol/l, 14.30 ± 4.35 μmol/l, and 14.81 ± 4.56 μmol/l, respectively (P = .93; ANOVA). No statistically significant difference was found in the proportion of patients with abnormal tHcy levels among the three diagnostic groups. In multivariate analysis, only age and positive smoking status were significantly correlated with total plasma homocysteine levels.

Conclusion

No significant difference was found in plasma homocysteine levels among POAG patients and normal control individuals.

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☆ InternetAdvance publication at ajo.com Sept 16, 2003

PII: S0002-9394(03)01129-2

doi:10.1016/j.ajo.2003.09.041

American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 401-406, March 2004

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