American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 420-425, March 2004

Sensitivity and specificity of the 76-suprathreshold visual field test to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting: the Thessaloniki eye study☆

  • Fotis Topouzis, MD

      Affiliations

    • Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (F.T., L.M., E.A., A.K., T.P., S.D.)
    • Corresponding Author InformationInquiries to Fotis Topouzis, MD, Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, St. Kyriakidis 1, 54636 Thessaloniki, Greece; fax: (+30) 2310-839497
    • ,
  • Anne L. Coleman, MD, PhD

      Affiliations

    • Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA (A.L.C., F.Y.)
    • ,
  • Fei Yu, PhD

      Affiliations

    • Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA (A.L.C., F.Y.)
    • ,
  • Leonidas Mavroudis, MD

      Affiliations

    • Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (F.T., L.M., E.A., A.K., T.P., S.D.)
    • ,
  • Eleftherios Anastasopoulos, MD

      Affiliations

    • Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (F.T., L.M., E.A., A.K., T.P., S.D.)
    • ,
  • Archimidis Koskosas, MD

      Affiliations

    • Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (F.T., L.M., E.A., A.K., T.P., S.D.)
    • ,
  • Theofanis Pappas, MD

      Affiliations

    • Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (F.T., L.M., E.A., A.K., T.P., S.D.)
    • ,
  • Stavros Dimitrakos, MD

      Affiliations

    • Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (F.T., L.M., E.A., A.K., T.P., S.D.)
    • ,
  • M.Roy Wilson, MD, MS

      Affiliations

    • Creighton University, Omaha, Nebraska, USA (M.R.W.)

Accepted 16 September 2003.

Abstract 

Purpose

To evaluate the screening performance of the 76-Suprathreshold (76-STHR) visual field test to detect eyes with visual field defect (VFD) as measured by Humphrey threshold testing in a population-based setting.

Design

Cross-sectional study.

Methods

All 88 subjects who agreed to participate in the pilot phase of the Thessaloniki Eye Study were included. Participants underwent a 76-STHR visual field test followed by a 30-full threshold (30-2 FTHR) test (Humphrey field analyzer). One eye/subject was randomly selected and included in the analysis. Sensitivity and specificity rates of the 76-STHR to detect eyes with VFD by the 30 to 2 FTHR test were calculated.

Results

When eyes with borderline results in the 30 to 2 FTHR test were classified as having a VFD, sensitivity rates of the 76-STHR to detect eyes with VFD by the 30 to 2 FTHR were 85.2%, 77.8%, and 74.1%, whereas specificity rates were 70%, 78%, and 86%, depending on the cutoff used for the 76-STHR.

Conclusions

The 76-STHR test showed high sensitivity and low false-negative results at the “at least one point missed” cutoff level criterion to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting. This criterion should be used when screening in a population-based study setting. By contrast, the 76-STHR would not be the appropriate screening test in a primary care setting with limited resources.

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☆ This study was supported by the International Glaucoma Association, London, United Kingdom, the Center for Eye Epidemiology, UCLA, Los Angeles, California, and the Health Future Foundation, Creighton University, Omaha, Nebraska.Biosketches and/or additional material at www.ajo.com

PII: S0002-9394(03)01133-4

doi:10.1016/j.ajo.2003.09.045

American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 420-425, March 2004

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