American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 415-419 , March 2004

New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty

  • Renata A. Rezende, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    • ,
  • Uchoandro B.C. Uchoa, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    • ,
  • Irving M. Raber, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    • ,
  • Christopher J. Rapuano, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    • ,
  • Peter R. Laibson, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    • ,
  • Elisabeth J. Cohen, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    • Corresponding Author InformationInquiries to Elisabeth J. Cohen, MD, Wills Eye Hospital, 840 Walnut St, Suite 920, Philadelphia PA 19107, USA; fax: (215) 928 3854

,Accepted 24 September 2003.

References 

  1. Kok-van Alphen CC, Volker-Dieben HJ. Diagnosis and treatment of complications in the follow up period after corneal transplantation. Doc Ophthalmol. 1979;46:227–235
  2. Levenson AE. Corneal transplantation (early postoperative management). In:  Brightbill FS editors. Corneal surgery (theory, technique and tissue). 3rd ed. St. Louis: CV Mosby; 1999;
  3. Portnoy SL, Beyer CF, Hill JM, Kaufman HE. The coincidence of HSV-1 ocular cultures with HSV-1 corneal epithelial defects in rabbits after experimental penetrating keratoplasty. Cornea. 1991;10:17–20
  4. Thoft RA. Epithelial lesions in surface rehabilitation. Int Ophthalmol Clin. 1979;19:257–274
  5. Wilson SE, Kaufman HE. Graft failure after penetrating keratoplasty. Surv Ophthalmol. 1986;34:325–356
  6. Kaufman HE. Can we prevent recurrences of herpes infections without antiviral drugs? The Weisenfeld lecture. Invest Ophthalmol Vis Sci. 2002;43:1325–1329
  7. Salisburg JD, Berkowitz RA, Gebhardt et al. Herpes virus infection of cornea allografts. Ophthalmic Surg 1984;15:406–408
  8. Beyer CF, Arens MQ, Hill GA, Rose BT, Beyer LR, Schanzlin DJ. Oral acyclovir reduces the incidence of recurrent herpes simplex keratitis in rabbits after penetrating keratoplasty. Arch Ophthalmol 1991;111:480–484
  9. Beyer CF, Byrd TJ, Hill JM, Kaufman HE. Herpes simplex virus and persistent epithelial defects after penetrating keratoplasty. Am J Ophthalmol. 1990;109:95–96
  10. Beyer CF, Hill JM, Reidy JJ, et al.  Corneal nerve disruption reactivates virus in rabbits latently infected with HSV-1. Invest Ophthalmol Vis Sci. 1990;31:925–932
  11. Pazin GJ, Ho M, Jannetta PJ. Reactivation of herpes simplex virus after decompression of the trigeminal nerve root. J Infect Dis. 1978;138:405
  12. Liesegang TJ. Herpes simplex virus epidemiology and ocular importance. Cornea. 2001;20:1–13
  13. Asbell PA. Valacyclovir for the prevention of recurrent herpes simplex virus eye disease after excimer laser photokeratectomy. Trans Am Ophthalmol Soc. 2000;98:285–303
  14. Kaufman HE, Baron BA, McDonald MB. The cornea. 2nd ed. [On CD-Rom.] Butterworth-Heinemann, 1999, Boston, MA
  15. Beyer CF, Arens MQ, Hill GA, et al.  Oral acyclovir reduces the incidence of recurrent herpes simplex keratitis in rabbits after penetrating keratoplasty. Arch Ophthalmol. 1989;107:1200–1205
  16. Haruta Y, Maguire LJ, Rootman DS, et al.  Recurrent herpes simplex virus type 1 corneal epithelial lesions after radial keratotomy in the rabbit. Arch Ophthalmol. 1987;106:692–694
  17. Rose BT, Beyer CF, Arens MQ, et al.  Recurrent herpetic keratitis following penetrating keratoplasty in rabbits. ARVO abstracts. Invest Ophthalmol Vis Sci. 1988;29(Suppl):453
  18. Haruta Y, Rootman DS, Xie L, et al.  Recurrent HSV-1 corneal lesions in rabbits induced by cyclophosphamide and dexamethasone. Invest Ophthalmol Vis Sci. 1989;30:371–376
  19. Cook SD. Herpes simplex infection in the eye. Br J Ophthalmol. 1992;76:365–366
  20. Remeijer L, Doornenbal P, Geerards AJM, Rijneveld WA, Beekhuis WH. Newly acquired herpes virus keratitis after penetrating keratoplasty. Ophthalmology. 1997;104:648–652
  21. Mannis MJ, Plotnik RD, Schwab IR, Newton RD. Herpes simplex keratitis after penetrating keratoplasty. Am J Ophthalmol 1991;111:480–484
  22. Cleator GM, Klapper PM, Dennet C, et al.  Corneal donor infection by herpes simplex virus (herpes simplex virus in donor corneas). Cornea. 1994;13:294–304
  23. Crouse CA, Pflugfelder SC, Pereira I, et al.  Detection of herpes viral genomes in normal and diseased corneal epithelium. Curr Eye Res. 1990;9:569–581
  24. Cantin EM, Chen J, McNeill J, et al.  Detection of herpes simplex viral DNA sequences in corneal transplant recipients by polymerase chain reaction assays. Curr Eye Res. 1991;10(Suppl):15–21
  25. Kaye SB, Lynas C, Patterson A, et al.  Evidence for herpes simplex viral latency in the human cornea. Br J Ophthalmol. 1991;75:195–200
  26. Sudesh S, Cohen EJ, Rapuano CJ, et al.  Corneal toxicity associated with latanoprost. Arch Ophthalmol. 1999;117:539–540
  27. Morales J, Shihab ZM, Brown SM, et al.  Herpes simplex virus dermatitis in patients using latanoprost. Am J Ophthalmol. 2001;132:114–116
  28. Kaufman HE, Varnell ED, Thompson HW. Latanoprost increases the severity and recurrence of herpetic keratitis in rabbit. Am J Ophthalmol. 1999;127:531–536
  29. Tambasco FP, Cohen EJ, Nguyen LH, et al.  Oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Arch Ophthalmol. 1999;117:445–449
  30. van Gelderen BE, Van der Lelij A, Treffers WF, et al.  Detection of herpes simplex virus type 1, 2 and varicella zoster virus DNA in recipient corneal buttons. Br J Ophthalmol. 2000;84:1238–1243

☆ Biosketches and/or additional material at www.ajo.com

PII: S0002-9394(03)01145-0

doi: 10.1016/j.ajo.2003.09.057

American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 415-419 , March 2004

Article Tools