American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 426-434 , March 2004

Comparability of two fundus photograph reading centers in grading cytomegalovirus retinitis progression

  • Larry D. Hubbard, MAT

      Affiliations

    • Department of Ophthalmology and Visual Sciences, the University of Wisconsin Medical School, Madison Wisconsin, USA (L.D.H.)
    • Corresponding Author InformationInquiries to Larry D. Hubbard, MAT, University of Wisconsin Fundus Photograph Reading Center, Park West One, 406 Science Drive, Suite 400, Madison, WI 53711-1068, USAfax: 608-263-0525
    • ,
  • Michelle O. Ricks, MS

      Affiliations

    • Department of Ophthalmology (M.O.R., N.M.B., J.H.K., J.P.D., D.A.J.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • ,
  • Barbara K. Martin, PhD

      Affiliations

    • Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (B.K.M., J.H.K., D.A.J.)
    • ,
  • Neil M. Bressler, MD

      Affiliations

    • Department of Ophthalmology (M.O.R., N.M.B., J.H.K., J.P.D., D.A.J.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • ,
  • John H. Kempen, MD, PhD

      Affiliations

    • Department of Ophthalmology (M.O.R., N.M.B., J.H.K., J.P.D., D.A.J.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (B.K.M., J.H.K., D.A.J.)
    • ,
  • James P. Dunn, MD

      Affiliations

    • Department of Ophthalmology (M.O.R., N.M.B., J.H.K., J.P.D., D.A.J.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • ,
  • Douglas A. Jabs, MD, MBA

      Affiliations

    • Department of Ophthalmology (M.O.R., N.M.B., J.H.K., J.P.D., D.A.J.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • Department of Medicine (D.A.J.), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (B.K.M., J.H.K., D.A.J.)
    • ,
  • Cytomegalovirus Retinitis and Viral Resistance Study Group

,Accepted 3 October 2003.

References 

  1. Diabetic Retinopathy Study Research Group . A modification of the Airlie House Classification of Diabetic Retinopathy (Diabetic Retinopathy study report 7). Invest Ophthalmol Vis Sci. 1981;21:210–226
  2. Chamberlin JA, Bressler NM, Bressler SB, et al.  The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation study. Ophthalmology. 1989;96:1526–1534
  3. Collaborative Ocular Melanoma Study Group . Design and methods for a clinical trial of a rare condition (COMS report number 3). Control Clin Trials. 1993;14:362–391
  4. Clarkson JG. Central Vein Occlusion Study (Photographic protocol and early natural history). Trans Am Ophthalmol Soc. 1994;92:203–213
  5. Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trial Group . Foscarnet B Ganciclovir Cytomegalovirus Retinitis trial. Report 1 (Rationale, design, and methods). Control Clin Trials. 1992;13:22–39
  6. Early Treatment Diabetic Retinopathy Study Research Group . Grading diabetic retinopathy from stereoscopic color fundus photographs — an extension of the Modified Airlie House Classification. ETDRS report number 10. Ophthalmology. 1991;98:786–806
  7. Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc. 1995;93:623–683
  8. Jabs DA, Enger C, Bartlett JG. Cytomegalovirus retinitis and acquired immunodeficiency syndrome. Arch Ophthalmol. 1989;107:75–80
  9. Palestine AG, Rodrigues MM, Macher AM, et al.  Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology. 1984;91:1092–1099
  10. Freeman WR, Lerner CW, Mines JA, et al.  A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome. Am J Ophthalmol. 1984;97:133–142
  11. Enger C, Jabs DA, Dunn JP, et al.  Viral resistance and CMV retinitis (Design and methods for a prospective study). Ophthalmic Epidemiol. 1997;4:41–48
  12. Holland GN, Buhles WC, Mastre B, Kaplan HJ  UCLA CMV Retinopathy Study Group . A controlled retrospective study of ganciclovir treatment for cytomegalovirus retinopathy (Use of a standardized system for the assessment of disease outcome). Arch Ophthalmol. 1989;107:1759–1766
  13. Palestine AG, Polis MA, De Smet MD, et al.  A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med. 1991;115:665–673
  14. Studies of Ocular Complications of AIDS Research Group, in Collaboration with the AIDS Clinical Trials Group . Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis. N Engl J Med. 1992;326:213–220
  15. The Studies of Ocular Complications of AIDS Research Group in Collaboration with AIDS Clinic Trials Group . Combination foscarnet and ganciclovir therapy vs monotherapy for the treatment of relapsed cytomegalovirus retinitis in patients with AIDS. Arch Ophthalmol. 1996;114:23–33
  16. Studies of Ocular Complications of AIDS Research Group in Collaboration with the AIDS Clinical Trials Group . Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS (The HPMPC Peripheral Cytomegalovirus Retinitis trial. A randomized, controlled trial). Ann Int Med. 1997;126:264–274
  17. Studies of Ocular Complications of AIDS Research Group, in collaboration with the AIDS Clinic Trials Group . MSL-109 adjuvant therapy for cytomegalovirus retinitis in patients with acquired immune deficiency syndrome (The Monoclonal Antibody Cytomegalovirus Retinitis trial). Arch Ophthalmol. 1997;115:1528–1536
  18. Studies of Ocular Complications of AIDS (SOCA) in collaboration with the AIDS Clinical Trial Group . Ganciclovir implant plus oral ganciclovir versus parenteral cidofovir for the treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome (The Ganciclovir Cidofovir Cytomegalovirus Retinitis trial). Am J Ophthalmol. 2001;131:457–467
  19. Holbrook JT, Davis MD, Hubbard LD, et al.  Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Arch Ophthalmol. 2000;118:1196–1204
  20. Holbrook JT, Meinert CL, Van Natta ML, et al.  Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients. Arch Ophthalmol. 2001;119:554–563
  21. Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group . Assessment of cytomegalovirus retinitis (Clinical evaluation vs centralized grading of fundus photographs). Arch Ophthalmol. 1996;114:791–805
  22. Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group . Evaluating treatment of cytomegalovirus retinitis (Clinical vs photographic assessment. Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial Report Number 8). Arch Ophthalmol. 1996;114:848–855
  23. Jabs DA, Martin BK, Forman MS, et al.  Cytomegalovirus resistance to ganciclovir and clinical outcomes of patients with cytomegalovirus retinitis. Am J Ophthalmol. 2003;135:26–34
  24. Studies of Ocular Complications of AIDS Research Group. SOCA General Handbook (version 1.0, May, 1997). Available from SOCA Coordinating Center, The Johns Hopkins Center for Clinical Trials, 615 N. Wolfe St., Baltimore, MD 21205
  25. Studies of the Ocular Complications of AIDS Research Group. SOCA cytomegalovirus retinitis grading protocol, 1997. Available from the National Technical Information Service, US Department of Commerce, 5285 Port Royal Road, Springfield, VA 22161: NTIS accession no. PB97-192082
  26. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174
  27. Lin LI. A concordance correlation coefficient to evaluate reproducibility. Biometrics. 1989;45:255–268
  28. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13–22
  29. Early Treatment Diabetic Retinopathy Study Research Group . Fundus photographic risk factors for progression of diabetic retinopathy (ETDRS report No. 12). Ophthalmology. 1991;98:823–833

☆ This research was supported by Grant R01-EY-10268 from the National Eye Institute, National Institutes of Health, Bethesda, MD. Additional support was obtained from NEI grants K23 EY00386 (J.H.K.) and K24 E4004505 (D.A.J.). Dr. Jabs is the recipient of a Research to Prevent Blindness Senior Scientific Investigator Award. Dr. Jabs is a Research to Prevent Blindness Senior Scientific Investigator.

PII: S0002-9394(03)01262-5

doi: 10.1016/j.ajo.2003.10.002

American Journal of Ophthalmology
Volume 137, Issue 3 , Pages 426-434 , March 2004

Article Tools

* Image Usage & Resolution