American Journal of Ophthalmology
Volume 138, Issue 4 , Pages 554-559 , October 2004

The effect of cataract surgery on ocular levels of topical moxifloxacin

Data from this article were presented in part at the Ocular Microbiology and Immunology Group meeting, in Anaheim, California, November 2003.

  • Rookaya Mather, MD

      Affiliations

    • From the Department of Ophthalmology, University of California, San Francisco, California; and the Francis I. Proctor Foundation for Research in Ophthalmology. Dr. Mather is now affiliated with the University of Western Ontario, Department of Ophthalmology, London, Ontario, Canada. Department of Ophthalmology (R.M.), University of Western Ontario, London, Ontario, Canada
    • ,
  • Jay M. Stewart, MD

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology (J.M.S., T.P., J.W., S.D.M.)
    • ,
  • Tisha Prabriputaloong, MD

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology (J.M.S., T.P., J.W., S.D.M.)
    • Cornea Service of the Department of Ophthalmology (T.P., S.D.M.), University of California, San Francisco, California, USA
    • ,
  • Joshua Wong, MS

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology (J.M.S., T.P., J.W., S.D.M.)
    • ,
  • Stephen D. McLeod, MD

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology (J.M.S., T.P., J.W., S.D.M.)
    • Cornea Service of the Department of Ophthalmology (T.P., S.D.M.), University of California, San Francisco, California, USA
    • Corresponding Author InformationInquiries to Stephen D. McLeod, MD, Department of Ophthalmology, University of California, San Francisco, K-301, Box 0730, 10 Kirkham St., San Francisco, CA, 94143, Phone: 415-502-5195, Fax: 415-476-2896

,Accepted 12 May 2004.

References 

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  2. Assalian A , Thompson P , St-Antoine P , et al.  Anterior chamber fluid contamination after uncomplicated phacoemulsification . J Cataract Refract Surg . 1995;21:539–542
  3. Speaker MG , Milch FA , Shah MK , Eisner W , Kreiswirth BN . Role of external bacterial flora in the pathogenesis of acute post-operative endophthalmitis . Ophthalmology . 1991;98:639–649
  4. Donnenfeld ED , Schrier A , Perry HD , et al.  Penetration of topically applied ciprofloxacin, norfloxacin, and ofloxacin into the aqueous humor . Ophthalmology . 1994;101:902–905
  5. Von Gunten S , Lew D , Paccolat F , et al.  Aqueous humor penetration of ofloxacin given by various routes . Am J Ophthalmol . 1994;117:87–89
  6. Nelson DB , Donnenfeld ED , Perry HD . Sterile endophthalmitis after sutureless cataract surgery . [comment] Ophthalmology . 1992;99:1655–1657
  7. Donnefeld ED , Perry HD , Synder RW , et al.  Intracorneal, aqueous humor, and vitreous humor penetration of topical and oral ofloxacin . Arch Ophthalmol . 1997;115:173–176
  8. Mather R , Karenchak LM , Romanowski EG , Kowalski RP . Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics . Am J Ophthalmol . 2002;133:463–466
  9. Kowalski RP, Romanowski EG, Mah FS, Yates KA, Gordon YJ.The prevention of bacterial endophthalmitis by topical moxifloxacin in a rabbit prophylaxis model. Am J Ophthalmol. Forthcoming.
  10. Kowalski RP , Pandya AN , Karenchak LM , et al.  An in vitro resistance study of levofloxacin, ciprofloxacin, and ofloxacin using keratitis isolates of Staphylococcus aureus and Pseudomonas aeruginosa . Ophthalmology . 2001;108:1826–1829
  11. Goldstein MH , Kowalski RP , Gordon YJ . Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review . Ophthalmology . 1999;106:1313–1318
  12. Alexandrakis G , Alfonso EC , Miller D . Shifting trends in bacterial keratitis in South Florida and emerging resistance to fluoroquinolones . Ophthalmology . 2000;107:1497–1502
  13. Ta CN , Egbert PR , Singh K , Shriver EM , Blumenkranz MS , Mino DeKaspar H . Prospective randomized comparison of 3-day versus 1-hour pre-operative ofloxacin prophylaxis for cataract surgery . Ophthalmology . 2002;109:2036–2040
  14. Hariprasad SM , Mieler WF , Holz ER . Vitreous and aqueous penetration of orally administered gatifloxacin in humans . Arch Ophthalmol . 2003;121:345–350
  15. Garcia-Saenz MC , Arias-Puente A , Fresnadillo-Martinez MJ , Carrasco-Font C . Human aqueous humor levels of oral ciprofloxacin, levofloxacin, and moxifloxacin . J Cataract Refract Surg . 2001;27:1969–1974
  16. Patton TF , Robinson JR . Quantitative precorneal disposition of topically applied pilocarpine nitrate in rabbit eyes . J Pharm Sci . 1976;65:1295–1301
  17. Chrai SS , Patton TF , Mehta A , Robinson R . Lacrimal and instilled fluid dynamics in rabbit eyes . J Pharm Sci . 1973;62:1112–1121

 Supported by an unrestricted research grant from Alcon Pharmaceutical, Fort Worth, Texas.This study was also supported by an unrestricted grant from Research to Prevent Blindness Inc., New York New York.

 Drs. McLeod and Mather have received consulting fees from Alcon Pharmaceutical, Fort Worth, Texas.

PII: S0002-9394(04)00530-6

doi: 10.1016/j.ajo.2004.05.011

American Journal of Ophthalmology
Volume 138, Issue 4 , Pages 554-559 , October 2004

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