American Journal of Ophthalmology
Volume 138, Issue 4 , Pages 567-573 , October 2004

Apolipoprotein E polymorphisms in Japanese patients with polypoidal choroidal vasculopathy and exudative age-related macular degeneration

  • Norimoto Gotoh, MD

      Affiliations

    • Department of Ophthalmology, Shinshu University School of Medicine (N.G., S.K., J.A., S.A., N.Y., N.Y.)
    • ,
  • Sachiko Kuroiwa, MD, PhD

      Affiliations

    • Department of Ophthalmology, Shinshu University School of Medicine (N.G., S.K., J.A., S.A., N.Y., N.Y.)
    • ,
  • Takanobu Kikuchi, PhD

      Affiliations

    • Research Center for Human and Enviromental Sciences (T.K.), Shinshu University, Matsumoto, Japan
    • ,
  • Jun Arai, MD

      Affiliations

    • Department of Ophthalmology, Shinshu University School of Medicine (N.G., S.K., J.A., S.A., N.Y., N.Y.)
    • ,
  • Satoko Arai, MD

      Affiliations

    • Department of Ophthalmology, Shinshu University School of Medicine (N.G., S.K., J.A., S.A., N.Y., N.Y.)
    • ,
  • Noriko Yoshida, MD

      Affiliations

    • Department of Ophthalmology, Shinshu University School of Medicine (N.G., S.K., J.A., S.A., N.Y., N.Y.)
    • ,
  • Nagahisa Yoshimura, MD, PhD

      Affiliations

    • Department of Ophthalmology, Shinshu University School of Medicine (N.G., S.K., J.A., S.A., N.Y., N.Y.)
    • Corresponding Author InformationInquiries to Nagahisa Yoshimura, MD, PhD, Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto 390–8621, Japan; fax: (+81) 263-32-9448

,Accepted 14 May 2004.

References 

  1. Yannuzzi LA , Sorenson J , Spaide RF , Lipson B . Idiopathic polypoidal choroidal vasculopathy (IPCV) . Retina . 1990;10:1–8
  2. Kleiner RC , Brucker AJ , Johnston RL . The posterior uveal bleeding syndrome . Retina . 1990;10:9–17
  3. Stern RM , Zakov ZN , Zegarra H , Gutman FA . Multiple recurrent serosanguineous retinal pigment epithelial detachments in black women . Am J Ophthalmol . 1985;100:560–569
  4. Perkovich BT , Zakov ZN , Berlin LA , Weidenthal D , Avins LR . An update on multiple recurrent serosanguineous retinal pigment epithelial detachments in black women . Retina . 1990;10:18–26
  5. Kies JC , Bird AC . Juxtapapillary choroidal neovascularization in older patients . Am J Ophthalmol . 1988;105:11–19
  6. Yannuzzi LA , Ciardella A , Spaide RF , et al.  The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy . Arch Ophthalmol . 1997;115:478–485
  7. Yannuzzi LA , Wong DWK , Sforzolini BS , et al.  Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration . Arch Ophthalmol . 1999;117:1503–1510
  8. Uyama M , Matsubara T , Fukushima I , et al.  Idiopathic polypoidal choroidal vasculopathy in Japanese patients . Arch Ophthalmol . 1999;117:1035–1042
  9. Uyama M , Wada M , Nagai Y , et al.  Polypoidal choroidal vasculopathy: natural history . Am J Ophthalmol . 2002;133:639–648
  10. Sho K , Takahashi K , Yoamada H , et al.  Polypoidal choroidal vasculopathy. Incidence, demographic features, and clinical characteristics . Arch Ophthalmol . 2003;121:1392–1396
  11. Spraul CW , Grossniklaus HE , Lang GK . Idiopathische polypose choroidale Vaskulpathie (IPCV) . Klin Monatsbl Augenheilkd . 1997;210:405–406
  12. Rosa RH , Davis JL , Eifrig CW . Clinicopathologic correlation of idiopathic polypoidal choroidal vasculopathy . Arch Ophthalmol . 2002;120:502–508
  13. Okubo A , Sameshima M , Uemura A , Kanda S , Ohba N . Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study . Br J Ophthalmol . 2002;86:1093–1098
  14. Kuroiwa S, Tateiwa H, Hisatomi T, Ishibashi T, Yoshimura, N. Pathologic features of surgically-excised polypoidal choroidal vasculopathy membranes. Clin Exp Ophthalmol 2004;32:297–302.
  15. Ross RD , Gitter KA , Cohen G , Schmaker KS . Idiopathic polypoidal choroidal vasculopathy associated with retinal arterial macroaneurysm and hypertensive retinopathy . Retina . 1996;16:105–111
  16. Ghiselli G , Gregg RE , Zech LA , Schaefer EJ , Brewer HB . Phenotype study of apolipoprotein E isoforms in hyperlipoproteinaemic patients . Lancet . 1982;2:405–407
  17. Davignon J , Gregg RE , Sing CF . Apolipoprotein E polymorphism and atherosclerosis . Arteriosclerosis . 1988;8:1–21
  18. Uusitupa M , Sarkkinen E , Kervinen K , Kesaniemi YA . Apolipoprotein E phenotype and blood pressure . [letter] Lancet . 1994;343:57
  19. de Knijff P , Boomsma DI , Feskens EJ , et al.  Apolipoprotein E phenotype and blood pressure . Lancet . 1994;343:1234–1235
  20. Katsuya T , Baba S , Ishikawa K , et al.  Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study . J Hypertens . 2002;20:2017–2021
  21. Klaver CC , Kliffen M , van Duijn CM , et al.  Genetic association of apolipoprotein E with age-related macular degeneration . Am J Hum Genet . 1998;63:200–206
  22. Souied EH , Benlian P , Amouyel P , et al.  The epsilon 4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration . Am J Ophthalmol . 1998;125:353–359
  23. Schmidt S , Saunders AM , De La Paz MA , et al.  Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender . Mol Vis . 2000;6:287–293
  24. Schultz DW , Klein ML , Humpert A , et al.  Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration . Arch Ophthalmol . 2003;121:679–683
  25. Pang CP , Baum L , Chan WM , et al.  The apolipoprotein E epsilon 4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese . Ophthalmologica . 2000;214:289–291
  26. Matsunaga A , Sasaki J , Moriyama K , et al.  Population frequency of apolipoprotein E5 (Glu3–>Lys) and E7 (Glu244–>Lys, Glu245–>Lys) variants in western Japan . Clin Genet . 1995;48:93–99
  27. Corbo RM , Scacchi R . Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a ‘thrifty’ allele? . Ann Hum Genet . 1999;63:301–310
  28. Tajima S , Yamamura T , Yamamoto A . Analysis of apolipoprotein E5 gene from a patient with hyperlipoproteinemia . J Biochem (Tokyo) . 1988;104:48–52
  29. Maeda H , Nakamura H , Kobori S , et al.  Identification of human apolipoprotein E variant gene: apolipoprotein E7 (Glu244,245—Lys244,245) . J Biochem (Tokyo) . 1989;105:51–54
  30. Simonelli F , Margaglione M , Testa F , et al.  Apolipoprotein E polymorphisms in age-related macular degeneration in an Italian population . Ophthalmic Res . 2001;33:325–328
  31. Stanga PE , Lim JI , Hamilton P . Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update . Ophthalmology . 2003;110:15–21
  32. Shastry BS . SNP alleles in human disease and evolution . J Hum Genet . 2002;47:561–566
  33. Menzel HJ , Kladetzky RG , Assmann G . Apolipoprotein E polymorphism and coronary artery disease . Arteriosclerosis . 1983;3:310–315
  34. Miyata M , Smith JD . Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides . Nat Genet . 1996;14:55–61
  35. Strittmatter WJ , Saunders AM , Schmechel D , et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease . Proc Natl Acad Sci U S A . 1993;90:1977–1981
  36. Corder EH , Saunders AM , Strittmatter WJ , et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families . Science . 1993;261:921–923
  37. Schmidt S , Klaver C , Saunders A , et al.  A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy . Ophthalmic Genet . 2002;23:209–223
  38. Copin B , Brezin AP , Valtot F , et al.  Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene . Am J Hum Genet . 2002;70:1575–1581
  39. Vickers JC , Craig JE , Stankovich J , et al.  The apolipoprotein epsilon 4 gene is associated with elevated risk of normal tension glaucoma . Mol Vis . 2002;8:389–393
  40. Ressiniotis T, Griffiths PG, Birch M, et al. The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma. Arch Ophthalmol 2004;122:258–261.
  41. Yamamura T , Dong LM , Yamamoto A . Characterization of apolipoprotein E7 (Glu(244)—>Lys, Glu(245)—>Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis . J Lipid Res . 1999;40:253–259
  42. Yamanouchi Y , Arinami T , Tsuchiya S , et al.  Apolipoprotein E5 and E7 in apparently healthy Japanese males: frequencies and relation to plasma lipid levels . Jpn J Hum Genet . 1994;39:315–324
  43. Gass JD . Biomicroscopic and histopathologic considerations regarding the feasibility of surgical excision of subfoveal neovascular membranes . Am J Ophthalmol . 1994;118:285–298

PII: S0002-9394(04)00544-6

doi: 10.1016/j.ajo.2004.05.025

American Journal of Ophthalmology
Volume 138, Issue 4 , Pages 567-573 , October 2004

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