American Journal of Ophthalmology
Volume 138, Issue 6 , Pages 936-951 , December 2004

The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24

  • Collaborative Ocular Melanoma Study Group

      Affiliations

    • Prepared by the COMS Steering Committee and other COMS Coordinating Center Investigators on behalf of all members of the COMS group. Lists of members of the COMS Group have been published.
    • Corresponding Author InformationInquiries on behalf of the COMS Group to Barbara S. Hawkins, PhD, COMS Coordinating Center, 550 N. Broadway, 9th Floor, Baltimore, MD 21205-2010; fax: (410) 955-0569; e-mail: bhawkins@jhmi.edu

,Accepted 6 July 2004.

References 

  1. Scotto J , Fraumeni JF , Lee JAH . Melanomas of the eye and other noncutaneous sites. Epidemiologic aspects . J Natl Cancer Inst . 1976;56:489–491
  2. Singh AD , Topham A . Incidence of uveal melanoma in the United States (1973–1997) . Ophthalmology . 2003;110:956–961
  3. Collaborative Ocular Melanoma Study Group . Design and methods of a clinical trial of a rare condition: The Collaborative Ocular Melanoma Study. COMS report no. 3 . Control Clin Trials . 1993;14:362–391
  4. Collaborative Ocular Melanoma Study Group . The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma. II. Initial mortality findings. COMS report no. 10 . Am J Ophthalmol . 1998;125:779–796 [Correction: 1998;126:622.]
  5. Collaborative Ocular Melanoma Study Group . Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS). COMS report no. 15 . Arch Ophthalmol . 2001;119:670–676
  6. Collaborative Ocular Melanoma Study Group . The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma. III. Local complications and observations following enucleation. COMS report no. 11 . Am J Ophthalmol . 1998;126:362–372
  7. Collaborative Ocular Melanoma Study Group . Histopathologic characteristics of uveal melanoma in eyes enucleated from the Collaborative Ocular Melanoma Study. COMS report no. 6 . [sic] Am J Ophthalmol . 1998;125:745–766
  8. Collaborative Ocular Melanoma Study Group . The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma. I. Characteristics of patients enrolled and not enrolled. COMS report no. 9 . Am J Ophthalmol . 1998;125:767–778
  9. Collaborative Ocular Melanoma Study Group . Echography (ultrasound) procedures for the Collaborative Ocular Melanoma Study (COMS). COMS report no. 12 . (pt 1), 219–232(pt 2) J Ophth Nurs Technol . 1999;18:143–149
  10. Collaborative Ocular Melanoma Study Group . Consistency of observations from echograms made centrally in the Collaborative Ocular Melanoma Study. COMS report no. 13 . Ophthalmic Epidemiol . 2002;9:11–27
  11. Collaborative Ocular Melanoma Study Group . Cause-specific mortality coding: Methods in the Collaborative Ocular Melanoma Study. COMS report no. 14 . Control Clin Trials . 2001;22:246–262
  12. Collaborative Ocular Melanoma Study Group. COMS Manual of Procedures. Accession no. PB95–179693. Springfield, Virginia: National Technical Information Service, January 1995.
  13. Collaborative Ocular Melanoma Study Group. COMS Forms Book. Accession no. PB98–139629. Springfield, Virginia: National Technical Information Service, August 1998.
  14. Kaplan EL , Meier P . Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457–481
  15. Mantel N . Evaluation of survival data and two new rank order statistics arising in its consideration . Cancer Chemother Rep . 1966;50: 163–160
  16. Peto R , Peto J . Asymptotically efficient rank invariant procedures . J R Stat Soc A . 1972;135(pt 2):185–206
  17. Shammas HF , Blodi FC . Prognostic factors in choroidal and ciliary body melanomas . Arch Ophthalmol . 1977;95:63–69
  18. Seddon JM , Albert DM , Lavin PT , Robinson N . A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma . Arch Ophthalmol . 1983;101:1894–1899
  19. Augsburger JJ , Gamel JW , Sardi VF , Greenberg RA , Shields JA , Brady LW . Enucleation vs cobalt plaque radiotherapy for malignant melanomas of the choroid and ciliary body . Arch Ophthalmol . 1986;104:655–661
  20. Flocks M , Gerende JH , Zimmerman LE . The size and shape of malignant melanomas of the choroid and ciliary body in relation to prognosis and histologic characteristics (A statistical study of 210 tumors) . Trans Am Acad Ophthalmol Otolaryngol . 1955;59:740–758
  21. Browman GP , Wong G , Hodson I , et al.   Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer . N Engl J Med . 1993;328:159–163
  22. Cox DR . Regression models and life-tables . J R Stat Soc B . 1972;34(pt 2):187–220
  23. Collaborative Ocular Melanoma Study Group . Comparison of clinical, echographic, and histologic measurements from eyes with medium-sized choroidal melanoma in the Collaborative Ocular Melanoma Study. COMS report no. 21 . Arch Ophthalmol . 2003;121:1163–1171
  24. Diener-West M , Hawkins BS , Markowitz JA , Schachat AP . A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988 . Arch Ophthalmol . 1992;110:245–250
  25. Damato BE , Paul J , Foulds WS . Risk factors for metastatic uveal melanoma after trans-scleral local resection . Br J Ophthalmol . 1996;80:109–116
  26. Garcia-Arumi J , Sararols L , Martinez V , Corcostegui B . Vitreoretinal surgery and endoresection in high posterior choroidal melanomas . Retina . 2001;21:445–452
  27. Bechrakis NE , Bornfeld N , Zoller I , Foerster MH . Iodine 125 plaque brachytherapy versus transscleral tumor resection in the treatment of large uveal melanomas . Ophthalmology . 2002;109:1855–1861
  28. Puusaari I , Heikkonen J , Summanen P , Tarkkanen A , Kivela T . Iodine brachytherapy as an alternative to enucleation for large uveal melanomas . Ophthalmology . 2003;110:2223–2234
  29. Shields CL, Naseripour M, Cater J, Shields JA, Demirci H, Youseff A, et al. Plaque radiotherapy for large posterior uveal melanomas (≥8-mm thick) in 354 consecutive patients . Ophthalmology . 2002;109:1838–1849
  30. Char DH , Kroll SM , Castro J . Ten-year follow-up of helium ion therapy for uveal melanoma . Am J Ophthalmol . 1998;125:81–89
  31. Egan KM , Gragoudas ES , Seddon JM , et al.   The risk of enucleation after proton beam irradiation of uveal melanoma . Ophthalmology . 1989;96:1377–1383

 The COMS has been sponsored by the National Eye Institute and National Cancer Institute, National Institutes of Health, U. S. Department of Health and Human Services, Bethesda, Maryland, through cooperative agreements EY06253, EY06257, EY06258, EY06260, EY06264, EY06265, EY06266, EY06268, EY06269, EY06270, EY06274, EY06275, EY06276, EY06279, EY06280, EY06282, EY06283, EY06284, EY06287, EY06288, EY06289, EY06291, EY06839, EY06843, EY06844, EY06848, EY06858, and EY06899. No member of the COMS Group has any pertinent financial interest.

PII: S0002-9394(04)00847-5

doi: 10.1016/j.ajo.2004.07.006

American Journal of Ophthalmology
Volume 138, Issue 6 , Pages 936-951 , December 2004