American Journal of Ophthalmology
Volume 139, Issue 1 , Pages 1-10 , January 2005

Morphologic analysis of stage 3 and stage 4 macular holes: Implications for treatment

  • Jon Wender, MD

      Affiliations

    • Albert Einstein College of Medicine, Bronx, New York, USA
    • ,
  • Tomohiro Iida, MD

      Affiliations

    • Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    • Vitreous-Retina-Macula Consultants of New York and LuEster T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York, USA
    • ,
  • Lucian V. Del Priore, MD, PhD

      Affiliations

    • Vitreous-Retina-Macula Consultants of New York and LuEster T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York, USA
    • Department of Ophthalmology, Harkness Eye Institute, Columbia University, New York, New York, USA
    • Corresponding Author InformationInquiries to Lucian V. Del Priore, MD, PhD, Robert L. Burch III Scholar, Department of Ophthalmology, Harkness Eye Institute of Columbia University, 635 West 165th St, New York, NY 10032; fax: (212) 342-1724

,Accepted 21 July 2004.

References 

  1. McDonnell PJ , Fine SL , Hillis AI . Clinical features of idiopathic macular cysts and holes . Am J Ophthalmol . 1982;93:777–786
  2. Morgan CM , Schatz H . Idiopathic macular holes . Am J Ophthalmol . 1985;99:437–444
  3. Morgan CM , Schatz H . Involutional macular thinning. A pre-macular hole condition . Ophthalmology . 1986;93:153–161
  4. Johnson RN , Gass JD . Idiopathic macular holes. Observations, stages of formation, and implications for surgical intervention . Ophthalmology . 1988;95:917–924
  5. Gass JD . Idiopathic senile macular hole (its early stages and pathogenesis) . Arch Ophthalmol . 1988;106:629–639
  6. Gass JD . Müller cell cone, an overlooked part of the anatomy of the fovea centralis . Arch Ophthalmol . 1999;117:821–823
  7. Smiddy WE . Atypical presentations of macular holes . Arch Ophthalmol . 1993;111:626–631
  8. Smiddy WE , Michels RG , de Bustros S , de la Cruz Z , Green WR . Histopathology of tissue removed during vitrectomy for impending idiopathic macular holes . Am J Ophthalmol . 1989;108:360–364
  9. Yooh HS , Brooks HL , Capone A , L’Hernault NL , Grossniklaus HE . Ultrastructural features of tissue removed during idiopathic macular hole surgery . Am J Ophthalmol . 1996;122:67–75
  10. Guyer DR , Green WR , de Bustros S , Fine SL . Histopathologic features of idiopathic macular holes and cysts . Ophthalmology . 1990;97:1045–1051
  11. Smiddy WE , Michels RG , Green WR . Morphology, pathology, and surgery of idiopathic vitreoretinal macular disorders. A review . Retina . 1990;10:288–296
  12. Spaide RF , Wong D , Fisher Y , Goldbaum M . Correlation of vitreous attachment and foveal deformation in early macular hole states . Am J Ophthalmol . 2002;133:226–229
  13. Smiddy WE , Michels RG , Glaser BM , de Bustros S . Vitrectomy for impending idiopathic macular holes . Am J Ophthalmol . 1988;105:371–376
  14. Jost BF , Hutton WL , Fuller DG , et al.   Vitrectomy in eyes at risk for macular hole formation . Ophthalmology . 1990;97:843–847
  15. Spaide RF . Macular hole repair with minimal vitrectomy . Retina . 2002;22:183–186
  16. Madreperla SA , McCuen BW , Hickingbotham D , Green WR . Clinicopathologic correlation of surgically removed macular hole opercula . Am J Ophthalmol . 1995;120:197–207
  17. Madreperla SA , McCuen BW , Hickingbotham D , Green WR . Clinicopathologic correlation of surgically removed macular hole opercula . [comment] Am J Ophthalmol . 1996;121:453–454
  18. Sadda SR , Campochiaro PA , de Juan E , Haller JA , Green WR . Histopathological features of vitreous removed at macular hole surgery . Arch Ophthalmol . 1999;117:478–483
  19. Gordon LW , Glaser BM , Ie D , Thompson JT , Sjaarda RN . Full-thickness macular hole formation in eyes with a pre-existing complete posterior vitreous detachment . Ophthalmology . 1995;102:1702–1705
  20. Lipham WJ , Smiddy WE . Idiopathic macular hole following vitrectomy (implications for pathogenesis) . Ophthalmic Surg Lasers . 1997;28:633–639
  21. Kakehashi A , Schepens CL , Trempe CL . Vitreomacular observations II. Data on the pathogenesis of idiopathic macular breaks . Graefes Arch Clin Exp Ophthalmol . 1996;234:425–433
  22. Roth DB , Smiddy WE , Feuer W . Vitreous surgery for chronic macular holes . Ophthalmology . 1997;104:2047–2052
  23. Ryan EH , Gilbert HD . Results of surgical treatment of recent-onset full-thickness idiopathic macular holes . Arch Ophthalmol . 1994;112:1545–1553
  24. Gaudric A , Haouchine B , Massin P , Paques M , Blain P , Erginay A . Macular hole formation. New data provided by optical coherence tomography . Arch Ophthalmol . 1999;117:744–751
  25. Spaide RF . Closure of an outer lamellar hole by vitrectomy (hypothesis for one mechanism of macular hole formation) . Retina . 2000;20:587–590
  26. Kishi S , Takahashi H . Three-dimensional observations of developing macular holes . Am J Ophthalmol . 2000;130:65–75
  27. Spiritus A , Dralands L , Stalmans P , Stalmans I , Spileers W . OCT study of fellow eyes of macular holes . Bull Soc Belge Ophthalmol . 2000;275:81–84
  28. Gass JDM . Stereoscopic atlas of macular diseases (diagnosis and treatment) . 4th ed. St Louis: Mosby; 1997;
  29. Guyer DR , Green WR . Idiopathic macular holes and precursor lesions . In:  Franklin RM editors. Proceedings of the Symposium on Retina and Vitreous, New Orleans Academy of Ophthalmology . New Orleans, La: Kugler; 1993;p. 135–162
  30. Brown GC . Macular hole following rhegmatogenous retinal detachment repair . Arch Ophthalmol . 1988;106:765–766
  31. Marmor MF . New hypotheses on the pathogenesis and treatment of serous retinal detachment . Graefes Arch Clin Exp Ophthalmol . 1988;226:548–552
  32. Birch DG , Jost BF , Fish GE . The focal electroretinogram in fellow eyes of patients with idiopathic macular holes . Arch Ophthalmol . 1988;106:1558–1563
  33. Smiddy WE , Feuer W , Cordahi G . Internal limiting membrane peeling in macular hole surgery . Ophthalmology . 2001;108:1471–1476
  34. Patel SC , Loo RH , Thompson JT , Sjaarda RN . Macular hole surgery in high myopia . Ophthalmology . 2001;108:377–380
  35. Negi A , Marmor MF . Quantitative estimation of metabolic transport of subretinal fluid . Invest Ophthalmol . 1986;27:1564–1658
  36. Marmor MF , Abdul-Rahim AS , Cohen DS . The effect of metabolic inhibitors on retinal adhesion and subretinal fluid resorption . Invest Ophthalmol . 1980;19:893–903
  37. Negi A , Marmor MF . The resorption of subretinal fluid after diffuse damage to the retinal pigment epithelium . Invest Ophthalmol Vis Sci . 1983;24:1475–1479
  38. In:  Zinn KM ,  Marmor MF editor. The retinal pigment epithelium. Adhesive forces between the retinal pigment epithelium and sensory retina . Cambridge, Mass: Harvard University Press; 1979;p. 192–204
  39. Bickerman JJ , Yap W . Rheology of peeling in a Newtonian liquid . Trans Soc Rheol . 1958;2:9

 Supported in part by the Eye Surgery Fund, the Robert L. Burch III Fund, the Macula Foundation, and Research to Prevent Blindness, Inc, New York, New York.

PII: S0002-9394(04)00926-2

doi: 10.1016/j.ajo.2004.07.038

American Journal of Ophthalmology
Volume 139, Issue 1 , Pages 1-10 , January 2005

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