American Journal of Ophthalmology
Volume 139, Issue 2 , Pages 242-246, February 2005

The effect of autologous serum eyedrops in the treatment of severe dry eye disease: A prospective randomized case-control study

Presented at the 28th Japan Cornea Congress, February 19–21, 2003, Yonago, Japan, and at the 2004 ARVO Meeting, Fort Lauderdale, Florida, April 26, 2004.

  • Takashi Kojima, MD

      Affiliations

    • Department of Ophthalmology, Social Insurance Chukyo Hospital, Aichi
    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Corresponding Author InformationTakashi Kojima, MD, Department of Ophthalmology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan 160-8582
    • ,
  • Reiko Ishida, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Eye Clinic Shizuoka, Shizuoka
    • ,
  • Murat Dogru, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • ,
  • Eiki Goto, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Department of Ophthalmology, Keio University, Keio, Japan
    • ,
  • Yukihiro Matsumoto, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • ,
  • Minako Kaido, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • ,
  • Kazuo Tsubota, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Department of Ophthalmology, Keio University, Keio, Japan

Accepted 18 August 2004. published online 10 January 2005.

Purpose

To evaluate the effectiveness of the autologous serum eyedrops in the treatment of severe dry eye patients.

Design

Prospective randomized case-control study.

Methods

Thirty-seven eyes of twenty severe dry eye patients without punctal occlusion were enrolled in this study. After 2 weeks of washout, they were randomly assigned to two groups. Group A patients used only preservative-free artificial tears, and group S patients used only autologous serum eyedrops. We evaluated the results of Schirmer test, fluorescein and rose bengal staining scores, tear film breakup time (BUT), and subjective symptom scores before and 2 weeks after treatment.

Results

Mean BUT and fluorescein and rose bengal staining scores, as well as subjective symptom scores, showed significant improvement in the patients assigned to autologous serum eyedrops compared with subjects assigned to preservative-free artificial tears after 2 weeks of treatment.

Conclusions

Autologous serum eyedrops were found effective in the treatment of severe dry eye disease, as evidenced by improvement of tear stability and ocular surface vital staining scores.

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 This study was supported by grants from the Japanese Ministry of Education and Science (Tokyo) and Hightech Research Center at Tokyo Dental College (Chiba, Japan).

PII: S0002-9394(04)01025-6

doi:10.1016/j.ajo.2004.08.040

American Journal of Ophthalmology
Volume 139, Issue 2 , Pages 242-246, February 2005

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