American Journal of Ophthalmology
Volume 139, Issue 2 , Pages 242-246 , February 2005

The effect of autologous serum eyedrops in the treatment of severe dry eye disease: A prospective randomized case-control study

Presented at the 28th Japan Cornea Congress, February 19–21, 2003, Yonago, Japan, and at the 2004 ARVO Meeting, Fort Lauderdale, Florida, April 26, 2004.

  • Takashi Kojima, MD

      Affiliations

    • Department of Ophthalmology, Social Insurance Chukyo Hospital, Aichi
    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Corresponding Author InformationTakashi Kojima, MD, Department of Ophthalmology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan 160-8582
    • ,
  • Reiko Ishida, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Eye Clinic Shizuoka, Shizuoka
    • ,
  • Murat Dogru, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • ,
  • Eiki Goto, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Department of Ophthalmology, Keio University, Keio, Japan
    • ,
  • Yukihiro Matsumoto, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • ,
  • Minako Kaido, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • ,
  • Kazuo Tsubota, MD

      Affiliations

    • Department of Ophthalmology, Tokyo Dental College, Chiba
    • Department of Ophthalmology, Keio University, Keio, Japan

,Accepted 18 August 2004.

References 

  1. Tsubota K . Tear dynamics and dry eye . Prog Retin Eye Res . 1998;17:565–596
  2. Tsubota K , Goto E , Shimmura S , Shimazaki J . Treatment of persistent corneal epithelial defect by autologous serum application . Ophthalmology . 1999;106:1984–1989
  3. Tsubota K , Goto E , Fujita H , et al.   Treatment of dry eye by autologous serum application in Sjogren’s syndrome . Br J Ophthalmol . 1999;83:390–395
  4. Goto E , Shimmura S , Shimazaki J , Tsubota K . Treatment of superior limbic keratoconjunctivitis by application of autologous serum . Cornea . 2001;20:807–810
  5. Poon AC , Geerling G , Dart JK , Fraenkel GE , Daniels JT . Autologous serum eyedrops for dry eyes and epithelial defects (clinical and in vitro toxicity studies) . Br J Ophthalmol . 2001;85:1188–1197
  6. Ogawa Y , Okamoto S , Mori T , et al.   Autologous serum eyedrops for the treatment of severe dry eye in patients with chronic graft-versus-host disease . Bone Marrow Transplant . 2003;31:579–583
  7. Matsumoto Y , Dogru M , Goto E , et al.   Autologous serum application in the treatment of neurotrophic keratopathy . Ophthalmology . 2004;111:1115–1120
  8. Danjo Y . Diagnostic usefulness and cutoff value of Schirmer’s I test in the Japanese diagnostic criteria of dry eye . Graefes Arch Clin Exp Ophthalmol . 1997;235:761–766
  9. Schirmer O . Studien zur physiologie und pathologie der tranenabsonderung und tranenabfuhr . Graefes Arch Clin Ophthalmol . 1903;56:197–291
  10. Toda I , Tsubota K . Practical double vital staining for ocular surface evaluation . Cornea . 1993;12:366–367
  11. van Bijsterveld OP . Diagnostic tests in the Sicca syndrome . Arch Ophthalmol . 1969;82:10–14
  12. Shimmura S , Ono M , Shinozaki K , et al.   Sodium hyaluronate eyedrops in the treatment of dry eyes . Br J Ophthalmol . 1995;79:1007–1011
  13. Fox RI , Robinson CA , Curd JG , Kozin F , Howell FV . Sjogren’s syndrome. Proposed criteria for classification . Arthritis Rheum . 1986;29:577–585
  14. Goto E , Yagi Y , Matsumoto Y , Tsubota K . Impaired functional visual acuity of dry eye patients . Am J Ophthalmol . 2002;133:181–186
  15. Takamura E , Shinozaki K , Hata H , Yukari J , Hori S . Efficacy of autologous serum treatment in patients with severe dry eye . Adv Exp Med Biol . 2002;506:1247–1250
  16. Tananuvat N , Daniell M , Sullivan LJ , et al.   Controlled study of the use of autologous serum in dry eye patients . Cornea . 2001;20:802–806
  17. Noble BA , Loh RS , MacLennan S , et al.   Comparison of autologous serum eyedrops with conventional therapy in a randomised controlled crossover trial for ocular surface disease . Br J Ophthalmol . 2004;88:647–652
  18. Yokoi N , Komuro A , Nishida K , Kinoshita S . Effectiveness of hyaluronan on corneal epithelial barrier function in dry eye . Br J Ophthalmol . 1997;81:533–536
  19. Aragona P , Papa V , Micali A , Santocono M , Milazzo G . Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye . Br J Ophthalmol . 2002;86:181–184

 This study was supported by grants from the Japanese Ministry of Education and Science (Tokyo) and Hightech Research Center at Tokyo Dental College (Chiba, Japan).

PII: S0002-9394(04)01025-6

doi: 10.1016/j.ajo.2004.08.040

American Journal of Ophthalmology
Volume 139, Issue 2 , Pages 242-246 , February 2005

Article Tools

* Image Usage & Resolution