American Journal of Ophthalmology
Volume 139, Issue 1 , Pages 44-55 , January 2005

Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography

  • Felipe A. Medeiros, MD

      Affiliations

    • Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, California
    • Department of Ophthalmology, University of São Paulo, São Paulo, Brazil.
  • ,
  • Linda M. Zangwill, PhD

      Affiliations

    • Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, California
  • ,
  • Christopher Bowd, PhD

      Affiliations

    • Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, California
  • ,
  • Roberto M. Vessani, MD

      Affiliations

    • Department of Ophthalmology, University of São Paulo, São Paulo, Brazil.
  • ,
  • Remo Susanna Jr, MD

      Affiliations

    • Department of Ophthalmology, University of São Paulo, São Paulo, Brazil.
  • ,
  • Robert N. Weinreb, MD

      Affiliations

    • Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, California
    • Corresponding Author InformationInquiries to Felipe A. Medeiros, MD, Hamilton Glaucoma Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946

,Accepted 26 August 2004.

References 

  1. Harwerth RS , Carter-Dawson L , Shen F , Smith EL , Crawford ML . Ganglion cell losses underlying visual field defects from experimental glaucoma . Invest Ophthalmol Vis Sci . 1999;40:2242–2250
  2. Sommer A , Katz J , Quigley HA , et al.   Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss . Arch Ophthalmol . 1991;109:77–83
  3. Kass MA , Heuer DK , Higginbotham EJ , et al.   The Ocular Hypertension Treatment Study (a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma) . Arch Ophthalmol . 2002;120:701–713 discussion 829–830
  4. Zeimer R , Asrani S , Zou S , Quigley H , Jampel H . Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study . Ophthalmology . 1998;105:224–231
  5. Greenfield DS , Bagga H , Knighton RW . Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography . Arch Ophthalmol . 2003;121:41–46
  6. Schuman JS , Pedut-Kloizman T , Hertzmark E , et al.   Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography . Ophthalmology . 1996;103:1889–1898
  7. Schuman JS , Hee MR , Puliafito CA , et al.   Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography . Arch Ophthalmol . 1995;113:586–596
  8. Bowd C , Weinreb RN , Williams JM , Zangwill LM . The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography . Arch Ophthalmol . 2000;118:22–26
  9. Zangwill LM , Bowd C , Berry CC , et al.   Discriminating between normal and glaucomatous eyes using the Heidelberg Retina Tomograph, GDx Nerve Fiber Analyzer, and Optical Coherence Tomograph . Arch Ophthalmol . 2001;119:985–993
  10. Williams ZY , Schuman JS , Gamell L , et al.   Optical coherence tomography measurement of nerve fiber layer thickness and the likelihood of a visual field defect . Am J Ophthalmol . 2002;134:538–546
  11. Bowd C , Zangwill LM , Berry CC , et al.   Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function . Invest Ophthalmol Vis Sci . 2001;42:1993–2003
  12. Schuman JS , Wollstein G , Farra T , et al.   Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy . Am J Ophthalmol . 2003;135:504–512
  13. Giovannini A , Amato G , Mariotti C . The macular thickness and volume in glaucoma (an analysis in normal and glaucomatous eyes using OCT) . Acta Ophthalmol Scand Suppl . 2002;236:34–36
  14. Lederer DE , Schuman JS , Hertzmark E , et al.   Analysis of macular volume in normal and glaucomatous eyes using optical coherence tomography . Am J Ophthalmol . 2003;135:838–843
  15. Guedes V , Schuman JS , Hertzmark E , et al.   Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes . Ophthalmology . 2003;110:177–189
  16. Hodapp E , Parrish RK , Anderson DR . Clinical decisions in glaucoma . St Louis: Mosby-Year Book; 1993;
  17. Bland JM , Altman DG . Statistical methods for assessing agreement between two methods of clinical measurement . Lancet . 1986;1:307–310
  18. Bland JM , Altman DG . Measuring agreement in method comparison studies . Stat Methods Med Res . 1999;8:135–160
  19. DeLong ER , DeLong DM , Clarke-Pearson DL . Comparing the areas under two or more correlated receiver operating characteristic curves (a nonparametric approach) . Biometrics . 1988;44:837–845
  20. Jolliffe IT . Principal component analysis . New York: Springer-Verlag; 2002;
  21. Daling JR , Tamura H . Use of orthogonal factors for selection of variables in a regression equation-an illustration . Appl Stat . 1970;19:260–268
  22. Jolliffe IT . Discarding variables in a principal component analysis . Appl Stat . 1972;21:160–173
  23. Sauerbrei W . The use of resampling methods to simplify regression models in medical statistics . Appl Statist . 1999;48:313–329
  24. Bleeker SE , Moll HA , Steyerberg EW , et al.   External validation is necessary in prediction research (a clinical example) . J Clin Epidemiol . 2003;56:826–832
  25. Greaney MJ , Hoffman DC , Garway-Heath DF , Nakla M , Coleman AL , Caprioli J . Comparison of optic nerve imaging methods to distinguish normal eyes from those with glaucoma . Invest Ophthalmol Vis Sci . 2002;43:140–145
  26. Kanamori A , Nakamura M , Escano MF , Seya R , Maeda H , Negi A . Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography . Am J Ophthalmol . 2003;135:513–520
  27. Nouri-Mahdavi K , Hoffman D , Tannenbaum DP , Law SK , Caprioli J . Identifying early glaucoma with optical coherence tomography . Am J Ophthalmol . 2004;137:228–235
  28. Jonas JB , Gusek GC , Naumann GO . Optic disc morphometry in chronic primary open-angle glaucoma. I. Morphometric intrapapillary characteristics . Graefes Arch Clin Exp Ophthalmol . 1988;226:522–530
  29. Jonas JB , Schiro D . Localised wedge shaped defects of the retinal nerve fibre layer in glaucoma . Br J Ophthalmol . 1994;78:285–290
  30. Xu L , Chen PP , Chen YY , Takahashi Y , Wang L , Mills RP . Quantitative nerve fiber layer measurement using scanning laser polarimetry and modulation parameters in the detection of glaucoma . J Glaucoma . 1998;7:270–277
  31. Ludbrook J . Statistical techniques for comparing measurers and methods of measurement (a critical review) . Clin Exp Pharmacol Physiol . 2002;29:527–536
  32. Tielsch JM , Katz J , Quigley HA , Miller NR , Sommer A . Intraobserver and interobserver agreement in measurement of optic disc characteristics . Ophthalmology . 1988;95:350–356
  33. Paunescu LA , Schuman JS , Price LL , et al.   Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using Stratus OCT . Invest Ophthalmol Vis Sci . 2004;45:1716–1724
  34. Lai E , Wollstein G , Price LL , et al.   Optical coherence tomography disc assessment in optic nerves with peripapillary atrophy . Ophthalmic Surg Lasers Imaging . 2003;34:498–504
  35. Steyerberg EW , Bleeker SE , Moll HA , Grobbee DE , Moons KG . Internal and external validation of predictive models (a simulation study of bias and precision in small samples) . J Clin Epidemiol . 2003;56:441–447

 Supported in part by the Foundation for Eye Research (F.A.M.) and NIH Grant EY11008 (L.M.Z.).

PII: S0002-9394(04)01081-5

doi: 10.1016/j.ajo.2004.08.069

American Journal of Ophthalmology
Volume 139, Issue 1 , Pages 44-55 , January 2005