American Journal of Ophthalmology
Volume 139, Issue 3 , Pages 421-428 , March 2005

The safety profile of long-term, high-dose intraocular corticosteroid delivery

  • Nancy M. Holekamp, MD

      Affiliations

    • Barnes Retina Institute, St. Louis, Missouri
    • Corresponding Author InformationInquiries to Nancy M. Holekamp, MD, Barnes Retina Institute, 1600 South Brentwood Boulevard, Suite 800, St. Louis, MO 63144; fax: (314) 367-1503
    • ,
  • Matthew A. Thomas, MD

      Affiliations

    • Barnes Retina Institute, St. Louis, Missouri
    • ,
  • Andrew Pearson, MD

      Affiliations

    • University of Kentucky, Lexington, Kentucky
    • Dr. Pearson has a financial interest in the subject matter.

,Accepted 4 October 2004.

References 

  1. Challa JK , Gillies MC , Penfold PL , et al.   Exudative macular degeneration and intravitreal triamcinolone (18 month follow up) . Aust N Z J Ophthalmol . 1998;26:277–281
  2. Danis RP , Ciulla TA , Pratt LM , Anliker W . Intravitreal triamcinolone acetonide in exudative age-related macular degeneration . Retina . 2000;20:244–250
  3. Ranson NT , Danis RP , Ciulla TA , Pratt L . Intravitreal triamcinolone in subfoveal recurrence of choroidal neovascularization after laser treatment in macular degeneration . Br J Ophthalmol . 2002;86:527–529
  4. Gillies MC , Simpson JM , Luo W , et al.   A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration (one-year results) . Arch Ophthalmol . 2003;121:667–673
  5. Roth DB , Chieh J , Spirn MJ , Green SN , Yarian DL , Chaudhry NA . Noninfectious endophthalmitis associated with intravitreal triamcinolone injection . Arch Ophthalmol . 2003;121:1279–1282
  6. Rechtman E , Allen VD , Danis RP , Pratt LM , Harris A , Speicher MA . Intravitreal triamcinolone for choroidal neovascularization in ocular histoplasmosis syndrome . Am J Ophthalmol . 2003;136:739–741
  7. Wang YS , Freiderichs U , Eichler W , Hoffman S , Wiedemann P . Inhibitory effets of triamcinolone acetonide on bFGF-induced migration and tube formation in choroidal microvascular endothelial cells . Graefes Arch Clin Exp Ophthalmol . 2002;240:42–48
  8. Kaven C , Spraul CW , Zavazava N , Lang GK , Lang GE . Thalidomide and prednisolone inhibit growth factor-induced human retinal pigment epithelium cell proliferation in vitro . Ophthalmologica . 2001;215:284–289
  9. Nauck M , Karakiulakis G , Perruchoud AP , et al.   Corticosteroids inhibit the expression of vascular endothelial growth factor gene in human vascular smooth muscle cells . Eur J Pharmacol . 1998;341:309–315
  10. Ciulla TA , Criswell MH , Danis RP , Hill TE . Intravitreal triamcinolone acetonide inhibits choroidal neovascularization in a laser-treated rat model . Arch Ophthalmol . 2001;119:399–404
  11. Taba KE , Rochas JC , Spee C , Hinton DR , Ashton P , Ryan SJ . Intravitreal sustained release fluocinolone implant inhibits experimental choroidal neovascularization . Invest Ophthalmol Vis Sci . 1999;40S:S172
  12. Ashton P , Blanford DL , Pearson PA , et al.   Review (Implants) . J Ocul Pharmacol . 1994;10:691–701
  13. Jaffe GJ , Yang CH , Guo H , Denny JP , Lima C , Ashton P . Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device . Invest Ophthalmol Vis Sci . 2000;41:3569–3575
  14. Martin DF , Parks DJ , Mellow SD , et al.   Treatment of cytomegalovirus retinitis with an intraocular sustained release ganciclovir implant. A randomized clinical trial . Arch Ophthalmol . 1994;112:1531–1539
  15. Jaffe GJ , Ben-Nun J , Guo H , Dunn JP , Ashton P . Fluocinolone acetonide sustained drug delivery device to treat severe uveitis . Ophthalmology . 2000;107:2024–2033
  16. Thomas MA , Dickinson JD , Melberg NS , Ibanez HE , Dhaliwal RS . Visual results after surgical removal of subfoveal choroidal neovascular membranes . Ophthalmology . 1994;101:1384–1396
  17. Berger AS , Kaplan HJ . Clinical experience with surgical removal of subfoveal neovascular membranes . Ophthalmology . 1992;99:969–976
  18. Gass JD . Biomicroscopic and histopathologic considerations regarding the feasibility of surgical excision of subfoveal neovascular membranes . Am J Ophthalmol . 1994;118:285–298
  19. Melberg NS , Thomas MA . Nuclear sclerotic cataract after vitrectomy in patients under 50 years of age . Ophthalmology . 1995;102:1466–1471

PII: S0002-9394(04)01241-3

doi: 10.1016/j.ajo.2004.10.005

American Journal of Ophthalmology
Volume 139, Issue 3 , Pages 421-428 , March 2005

Article Tools

* Image Usage & Resolution