Corneal higher-order aberrations induced by overnight orthokeratology

Hiraoka, Takahiro; Matsumoto, Yujiro; Okamoto, Fumiki; Yamaguchi, Tatsuo; Hirohara, Yoko; Mihashi, Toshifumi; Oshika, Tetsuro

doi:10.1016/j.ajo.2004.10.006

« Previous Next »American Journal of Ophthalmology
Volume 139, Issue 3 , Pages 429-436, March 2005

Corneal higher-order aberrations induced by overnight orthokeratology

Takahiro Hiraoka, MD
- Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
- Inquiries to Takahiro Hiraoka, MD, Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1, Tennoudai, Tsukuba, Ibaraki, 305-8575 Japan; fax: +81-29-853-3214
Yujiro Matsumoto, MD
- Matsumoto Eye Clinic, Ibaraki, Japan
Fumiki Okamoto, MD
- Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Tatsuo Yamaguchi, BS
- Technical Research Institute, Topcon Corporation, Tokyo, Japan.
Yoko Hirohara, BS
- Technical Research Institute, Topcon Corporation, Tokyo, Japan.
Toshifumi Mihashi, BE
- Technical Research Institute, Topcon Corporation, Tokyo, Japan.
Tetsuro Oshika, MD
- Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Accepted 1 October 2004. published online 28 January 2005.

Purpose

To evaluate corneal higher-order aberrations induced by overnight orthokeratology for myopia.

Design

Prospective, noncomparative, consecutive, interventional case series.

Methods

A prospective study was conducted in 64 eyes of 39 patients with overnight orthokeratology for myopia, who were followed up for at least 3 months and attained uncorrected visual acuity of 20/20 or better. Corneal height data were obtained with computerized videokeratography (TMS-2N, Tomey), and wavefront aberration was derived using Zernike polynomials. Higher-order aberrations of the cornea were calculated for 3- and 6-mm pupils.

Results

Orthokeratology significantly reduced manifest refraction from −2.60 ± 1.13 (mean ± SD) diopters to −0.17 ± 0.31 diopters (P < .0001, paired t test). Root-mean-square (RMS) of third-order (coma-like) aberrations significantly increased by orthokeratology for both 3-mm (P < .0001, paired t test) and 6-mm (P < .0001) pupils. Fourth-order RMS (spherical-like) aberrations increased significantly by the treatment for both 3-mm (P < .0001) and 6-mm (P < .0001) pupils. Vertical coma significantly changed from positive to negative for both 3-mm (P = .0323) and 6-mm (P < .0001) pupils. Horizontal coma significantly increased to the positive direction for both 3-mm (P < .0001) and 6-mm (P < .0001) pupils. Increases in the third- and fourth-order RMS showed significant positive correlations with the amount of myopic correction for 3-mm (Pearson correlation coefficient, r = .452, P = .0001 for third-order RMS, r = .381, P = .0017 for fourth-order RMS) and 6-mm (r = .499, P < .0001, r = .455, P = .0001) pupils.

Conclusions

Corneal higher-order aberrations significantly increased, even in clinically successful orthokeratology cases. The increases in the higher-order aberrations correlated with the magnitude of myopic correction.