American Journal of Ophthalmology
Volume 139, Issue 3 , Pages 468-475 , March 2005

Iris melanocytoma: Clinical features and natural course in 47 cases

Presented in part at the annual meeting of The Association for Research in Vision and Ophthalmology, Ft. Lauderdale, Florida, May 2003 (H.D.) and at the annual meeting of American Academy of Ophthalmology, New Orleans, Louisiana, October, 2004 (H.D.).

  • Hakan Demirci, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    • ,
  • Arman Mashayekhi, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    • ,
  • Carol L. Shields, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    • Corresponding Author InformationInquiries to Carol L. Shields, MD Oncology Service, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA 19107; fax: 215-928-1140
    • ,
  • Ralph C. Eagle Jr, MD

      Affiliations

    • Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    • ,
  • Jerry A. Shields, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

,Accepted 4 October 2004.

References 

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  2. Shields JA , Shields CL . Posterior uveal melanocytoma . In:  Shields JA ,  Shields CL editor. Atlas of intraocular tumors . Philadelphia: Lippincott, Williams and Wilkins; 1999;p. 61–72
  3. Shields JA , Demirci H , Mashayekhi A , Shields CL . Melanocytoma of optic disc in 115 cases (The 2004 Samuel Jackson Memorial Lecture, part I) . Ophthalmology . 2004;111:1739–1746
  4. Shields JA , Augsburger JJ , Bernardino V , Eller AW . Melanocytoma of the ciliary body and iris . Am J Ophthalmol . 1980;89:632–635
  5. Shields JA , Annesley WH , Spaeth GL . Necrotic melanocytoma of iris with secondary glaucoma . Am J Ophthalmol . 1977;84:826–829
  6. Fineman M , Eagle RC , Shields JA , Shields CL , De Potter P . Melanocytomalytic glaucoma in eyes with necrotic iris melanocytoma . Ophthalmology . 1998;105:492–496
  7. Shields JA , Eagle RC , Shields CL , Nelson LB . Progressive growth of an iris melanocytoma in a child . Am J Ophthalmol . 2002;133:287–289
  8. Cialdini AP , Sahel JA , Jalkh AE , Weiter JJ , Zakka K , Albert DM . Malignant transformation of an iris melanocytoma . Graefe’s Arch Clin Exp Ophthalmol . 1989;227:348–354
  9. Teichmann KD , Karcioglu ZA . Melanocytoma of the iris with rapidly developing secondary glaucoma . Surv Ophthalmol . 1995;40:136–144
  10. Nakazawa M , Tamai M . Iris melanocytoma with secondary glaucoma . Am J Ophthalmol . 1984;97:797–799
  11. Kiratli H , Bilgic S , Gedik S . Late normalization of melanocytomalytic intraocular pressure elevation following excision of iris melanpcytoma . Graefe’s Arch Clin Exp Ophthalmol . 2001;239:712–715
  12. Fountain TR , Goldberg MF , Green WR . Glaucoma and a melanocytic iris lesion in an-18-year-old . In:  Schachat AP editors. Current practice in ophthalmology . St. Louis: Mosby; 1992;p. 371–380
  13. Green WR . Uveal tract . In:  Spencer WH editors. Ophthalmic pathology . Philadelphia: WB Saunders; 1996;p. 1608–1609 An atlas and textbook.
  14. Thomas CI , Purnell EW . Ocular melanocytoma . Am J Ophthalmol . 1969;67:79–86
  15. Scheie HG , Yanoff M . Pseudomelanoma of the ciliary body . Arch Ophthalmol . 1967;77:81–83
  16. Rummelt V , Naumann GOH , Foldberg R , Weingeist TA . Surgical management of melanocytoma of the ciliary body with extrascleral extension . Am J Ophthalmol . 1994;117:169–176
  17. Shields JA , Sanborn GE , Augsburger JJ . The differential diagnosis of malignant melanoma of the iris. A clinical study of 200 patients . Ophthalmology . 1983;90:716–720
  18. Jakobiec FA , Silbert A . Are most iris “melanomas” really nevi? A clinicopathological study of 189 lesions . Arch Ophthalmol . 1981;99:2117–2132
  19. Territo C , Shields CL , Shields JA , Augsburger JJ , Schroeder RP . Natural course of melaonocytic tumors of the iris . Ophthalmology . 1988;95:1251–1255
  20. Shields CL , Shields JA , Materin M , Gershenbaum E , Singh AD , Smith A . Iris melanoma. Risk factors for metastasis in 169 consecutive patients . Ophthalmology . 2000;108:172–178
  21. Van Buskirk EM , Leure-DuPree AE . Pathophysiology and electron microscopy of melanomalytic glaucoma . Am J Ophthalmol . 1978;85:160–166
  22. McMenamin PG , Lee WR . Ultrastructural pathology melanomalytic glaucoma . Br J Ophthalmol . 1986;70:895–906
  23. Shields JA , Shields CL , Ehya H , Eagle RC , De Potter P . Fine-needle aspiration biopsy of suspected intraocular tumors. The 1992 Urwick lecture . Ophthalmology . 1993;100:1677–1684

 Support provided by the International Award of Merit in Retina Research, Houston, Texas (J.A.S.), Rosenthal Award of the Macula Society (C.L.S.), Macula Foundation, New York, New York (C.L.S.), the Noel T. and Sara L. Simmonds Endowment for Ophthalmic Pathology, Wills Eye Hospital (R.C.E., Jr.) and the Eye Tumor Research Foundation, Philadelphia, Pennsylvania (C.L.S., J.A.S.).

PII: S0002-9394(04)01246-2

doi: 10.1016/j.ajo.2004.10.008

American Journal of Ophthalmology
Volume 139, Issue 3 , Pages 468-475 , March 2005

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