American Journal of Ophthalmology
Volume 139, Issue 4 , Pages 611-619 , April 2005

Autologous cultivated conjunctival transplantation for pterygium surgery

The material was presented in part at the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), May 5–10, 2002, Fort Lauderdale, Florida.

  • Leonard P.K. Ang (FRCS, MRCOphth)

      Affiliations

    • Singapore National Eye Center, Singapore
    • Department of Ophthalmology, National University of Singapore, Singapore
    • Singapore Eye Research Institute, Singapore
    • ,
  • Donald T.H. Tan (FRCS, FRCOphth)

      Affiliations

    • Singapore National Eye Center, Singapore
    • Department of Ophthalmology, National University of Singapore, Singapore
    • Singapore Eye Research Institute, Singapore
    • Corresponding Author InformationInquiries to Donald T.H. Tan, FRCS, Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751; fax: (65) 6323 1903
    • ,
  • Howard Cajucom-Uy, MD

      Affiliations

    • Singapore National Eye Center, Singapore
    • ,
  • Roger W. Beuerman, PhD

      Affiliations

    • Singapore Eye Research Institute, Singapore

,Accepted 20 October 2004.

References 

  1. Cardillo JA , Alves MR , Ambrosio LE , Poterio MB , Jose NK . Single intraoperative application versus postoperative mitomycin C eye drops in pterygium surgery . Ophthalmology . 1995;102:1949–1952
  2. Lam DS , Wong AK , Fan DS , et al.   Intraoperative mitomycin C to prevent recurrence of pterygium after excision (a 30-month follow-up study) . Ophthalmology . 1998;105:901–904
  3. Manning CA , Kloess PM , Diaz MD , Yee RW . Intraoperative mitomycin in primary pterygium excision. A prospective, randomized trial . Ophthalmology . 1997;104:844–848
  4. Chen PP , Ariyasu RG , Kaza V , LaBree LD , McDonnell PJ . A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium . Am J Ophthalmol . 1995;120:151–160
  5. Aswad MI , Baum J . Optimal time for postoperative irradiation of pterygia . Ophthalmology . 1987;94:1450–1451
  6. Lewallen S . A randomized trial of conjunctival autografting for pterygium in the tropics . Ophthalmology . 1989;96:1612–1624
  7. Mahar PS . Conjunctival autograft versus topical mitomycin C in treatment of pterygium . Eye . 1997;11:790–792
  8. Tan DTH , Chee SP , Dear KBG , Lim ASM . Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision . Arch Ophthalmol . 1997;115:1235–1240
  9. Jap A , Chan C , Lim L , Tan DT . Conjunctival autorotation autograft for pterygium. An alternative to conjunctival autografting . Ophthalmology . 1999;106:67–71
  10. Mutlu FM , Sobaci G , Tatar T , Yildirim E . A comparative study of recurrent pterygium surgery (limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap) . Ophthalmology . 1999;106:817–821
  11. Lei G . Surgery for pterygium using a conjunctival pedunculated flap slide . Br J Ophthalmol . 1996;80:33–34
  12. Prabhasawat P , Barton K , Burkett G , Tseng SC . Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision . Ophthalmology . 1997;104:974–985
  13. Solomon A , Pires RT , Tseng SC . Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia . Ophthalmology . 2001;108:449–460
  14. Ma DH , See LC , Liau SB , Tsai RJ . Amniotic membrane graft for primary pterygium (comparison with conjunctival autograft and topical mitomycin C treatment) . Br J Ophthalmol . 2000;84:973–978
  15. Shimazaki J , Kosaka K , Shimmura S , Tsubota K . Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium . Ophthalmology . 2003;110:119–124
  16. Vrabec MP , Weisenthal RW , Elsing SH . Subconjunctival fibrosis after conjunctival autograft . Cornea . 1993;12:181–183
  17. Rubinfeld RS , Pfister RR , Stein RM , et al.   Serious complications of topical mitomycin-C after pterygium surgery . Ophthalmology . 1992;99:1647–1654
  18. MacKenzie FD , Hirst LW , Kynaston B , Bain C . Recurrence rate and complications after beta irradiation for pterygia . Ophthalmology . 1991;98:1776–1780
  19. Ang LPK , Tan DTH , Phan TT , Li J , Beuerman RW , Lavker RM . The in vitro and in vivo proliferative capacity of serum-free cultivated human conjunctival epithelial cells . Curr Eye Res . 2004;28(5):307–317
  20. Tan DTH , Ang LPK , Cajucom-Uy H , Beuerman RW . Reconstruction of the ocular surface by transplantation of a serum-free derived cultivated conjunctival epithelial equivalent . Transplantation . 2004;77(11):1729–1734
  21. Tsai RJ , Li LM , Chen JK . Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells . N Engl J Med . 2000;343:86–93
  22. Koizumi N , Inatomi T , Suzuki T , Sotozono C , Kinoshita S . Cultivated corneal epithelial stem cell transplantation in ocular surface disorders . Ophthalmology . 2001;108:1569–1574
  23. Tarr KH , Constable IJ . Late complications of pterygium treatment . Br J Ophthalmol . 1980;64:496–505
  24. Dougherty PJ , Hardten DR , Lindstrom RL . Corneoscleral melt after pterygium surgery using a single intraoperative application of mitomycin-C . Cornea . 1996;15:537–540
  25. Ti SE , Chee SP , Dear KB , et al.   Analysis of variation in success rates in conjunctival autografting for primary and recurrent pterygium . Br J Ophthalmol . 1999;84:385–389
  26. Alsagoff Z , Tan DTH , Chee SP . Necrotising scleritis after bare sclera excision of pterygium . Br J Ophthalmol . 2000;84:1050–1052
  27. Ti SE , Tan DTH . Tectonic corneal lamellar grafting for severe scleral melting after pterygium surgery . Ophthalmology . 2003;110:1126–1136
  28. Wagoner MD , Kenyon KR . Conjunctival transplantation for pterygium and other ocular surface disorders . In:  Bruner WR ,  Stark WJ ,  Maumenee AE editor. A manual of corneal surgery . New York: Churchill Livingstone; 1987;p. 119–128
  29. Kenyon KR . Decision making in the therapy of external eye disease (noninfected corneal ulcers) . Ophthalmology . 1982;89:44–51
  30. Johnson-Wint B , Gross J . Regulation of connective tissue collagenase production (stimulation from adult and fetal epidermal cells) . J Cell Biol . 1984;98:90–96

 Supported in part by the Singapore Biomedical Research Council Grant R268/12/2002.

PII: S0002-9394(04)01334-0

doi: 10.1016/j.ajo.2004.10.056

American Journal of Ophthalmology
Volume 139, Issue 4 , Pages 611-619 , April 2005

Article Tools

* Image Usage & Resolution