American Journal of Ophthalmology
Volume 139, Issue 4 , Pages 605-610 , April 2005

Photoreceptor apoptosis in human retinal detachment

  • Jorge G. Arroyo, MD, MPH

      Affiliations

    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Corresponding Author InformationInquiries to Jorge G. Arroyo, MD, Retina Service, Division of Ophthalmology, Beth Israel Deaconess Medical Center, Shapiro 5th Floor, 330 Brookline Avenue, Boston, Massachusetts 02215; fax: 617- 667-5025
    • ,
  • Liu Yang, MD, PhD

      Affiliations

    • Schepens Eye Research Institute, Boston, Massachusetts
    • ,
  • Deisy Bula, MD

      Affiliations

    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
    • ,
  • Dong Feng Chen, MD, PhD

      Affiliations

    • Schepens Eye Research Institute, Boston, Massachusetts

,Accepted 18 November 2004.

References 

  1. Hassan TS , Sarrafizadeh R , Ruby AJ , Garretson BR , Kuczynski B , Williams GA . The effect of duration of macular detachment on results after the scleral buckle repair of primary, macula-off retinal detachments . Ophthalmology . 2002;109:146–152
  2. Ross WH . Visual recovery after macula-off retinal detachment . Eye . 2002;16:440–446
  3. McCuen BWd , Azen SP , Stern W , et al.   Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy. Silicone Study Report 3 . Retina . 1993;13:279–284
  4. Cook B , Lewis GP , Fisher SK , Adler R . Apoptotic photoreceptor degeneration in experimental retinal detachment . Invest Ophthalmol Vis Sci . 1995;36:990–996
  5. Lewis GP , Charteris DG , Sethi CS , Fisher SK . Animal models of retinal detachment and reattachment (identifying cellular events that may affect visual recovery) . Eye . 2002;16:375–387
  6. Hisatomi T , Sakamoto T , Goto Y , et al.   Critical role of photoreceptor apoptosis in functional damage after retinal detachment . Curr Eye Res . 2002;24:161–172
  7. Lewis GP , Sethi CS , Linberg KA , Charteris DG , Fisher SK . Experimental retinal reattachment (a new perspective) . Mol Neurobiol . 2003;28:159–175
  8. Jackson TL , Hillenkamp J , Williamson TH , Clarke KW , Almubarak AI , Marshall J . An experimental model of rhegmatogenous retinal detachment (surgical results and glial cell response) . Invest Ophthalmol Vis Sci . 2003;44:4026–4034
  9. Zacks DN , Hanninen V , Pantcheva M , Ezra E , Grosskreutz C , Miller JW . Caspase activation in an experimental model of retinal detachment . Invest Ophthalmol Vis Sci . 2003;44:1262–1267
  10. Yang L , Bula D , Arroyo JG , Chen DF . Preventing retinal detachment-associated photoreceptor cell loss in Bax-deficient mice . Invest Ophthalmol Vis Sci . 2004;45:648–654
  11. Chang CJ , Lai WW , Edward DP , Tso MO . Apoptotic photoreceptor cell death after traumatic retinal detachment in humans . Arch Ophthalmol . 1995;113:880–886
  12. Jacobs GH , Calderone JB , Sakai T , Lewis GP , Fisher SK . An animal model for studying cone function in retinal detachment . Doc Ophthalmol . 2002;104:119–132
  13. Erickson PA , Fisher SK , Anderson DH , Stern WH , Borgula GA . Retinal detachment in the cat (the outer nuclear and outer plexiform layers) . Invest Ophthalmol Vis Sci . 1983;24:927–942
  14. Hisatomi T , Sakamoto T , Murata T , et al.   Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo . Am J Pathol . 2001;158:1271–1278
  15. Lewis GP , Charteris DG , Sethi CS , Leitner WP , Linberg KA , Fisher SK . The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment . Invest Ophthalmol Vis Sci . 2002;43:2412–2420
  16. Esser P , Heimann K , Bartz-Schmidt KU , Walter P , Krott R , Weller M . Plasminogen in proliferative vitreoretinal disorders . Br J Ophthalmol . 1997;81:590–594
  17. El Ghrably I , Powe DG , Orr G , et al.   Apoptosis in proliferative vitreoretinopathy . Invest Ophthalmol Vis Sci . 2004;45:1473–1479

 Dr. Arroyo is a recipient of a NIH K-23 Mentored Patient-Oriented Research Career Development Award.

PII: S0002-9394(04)01409-6

doi: 10.1016/j.ajo.2004.11.046

American Journal of Ophthalmology
Volume 139, Issue 4 , Pages 605-610 , April 2005

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