American Journal of Ophthalmology
Volume 139, Issue 5 , Pages 780-794 , May 2005

Clinical and Electrophysiologic Characterization of Paraneoplastic and Autoimmune Retinopathies Associated With Antienolase Antibodies

  • Richard G. Weleber, MD

      Affiliations

    • Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon
    • Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon
    • Corresponding Author InformationInquiries to Richard G. Weleber, MD, Casey Eye Institute, 3375 SW Terwilliger Blvd, Portland, OR 97239-4197; fax: (503) 494-5347
    • ,
  • Robert C. Watzke, MD

      Affiliations

    • Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon
    • ,
  • William T. Shults, MD

      Affiliations

    • Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon
    • Devers Eye Institute, Portland, Oregon
    • ,
  • Karmen M. Trzupek, MS

      Affiliations

    • Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon
    • ,
  • John R. Heckenlively, MD

      Affiliations

    • Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan
    • ,
  • Robert A. Egan, MD

      Affiliations

    • Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon
    • Department of Neurology, Oregon Health & Science University, Portland, Oregon
    • Department of Neurosurgery, Oregon Health & Science University, Portland, Oregon
    • ,
  • Grazyna Adamus, PhD

      Affiliations

    • Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon
    • Neurological Sciences Institute, Oregon Health & Science University (West Campus), Beaverton, Oregon.

,Accepted 30 December 2004.

References 

  1. Sawyer RA , Selhorst JB , Zimmerman LE , Hoyt WF . Blindness caused by photoreceptor degeneration as a remote effect of cancer . Am J Ophthalmol . 1976;81:606–613
  2. Thirkill CE , Tait RC , Tyler NK , Roth AM , Keltner JL . The cancer-associated retinopathy antigen is a recoverin-like protein . Invest Ophthalmol Vis Sci . 1992;33:2768–2772
  3. Polans AS , Burton MD , Haley TL , Crabb JW , Palczewski K . Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy . Invest Ophthalmol Vis Sci . 1993;34:81–90
  4. Adamus G , Aptsiauri N , Guy J , Heckenlively J , Flannery J , Hargrave PA . The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy . Clin Immunol Immunopathol . 1996;78:120–129
  5. Adamus G , Ren G , Weleber RG . Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy . BMC Ophthalmol . 2004;4:5; Available at http://www.biomedcentral.com/1471-2415/4/5. Accessed December 21, 2004.
  6. Klingele TG , Burde RM , Rappazzo JA , Isserman MJ , Burgess D , Kantor O . Paraneoplastic retinopathy . J Clin Neuroophthalmol . 1984;4:239–245
  7. Berson EL , Lessell S . Paraneoplastic night blindness with malignant melanoma . Am J Ophthalmol . 1988;106:307–311
  8. Matsui Y , Mehta MC , Katsumi O , Brodie SE , Hirose T . Electrophysiological findings in paraneoplastic retinopathy . Graefes Arch Clin Exp Ophthalmol . 1992;230:324–328
  9. Adamus G , Guy J , Schmied JL , Arendt A , Hargrave PA . Role of anti-recoverin autoantibodies in cancer-associated retinopathy . Invest Ophthalmol Vis Sci . 1993;34:2626–2633
  10. Ohguro H , Yokoi Y , Ohguro I , et al.   Clinical and immunologic aspects of cancer-associated retinopathy . Am J Ophthalmol . 2004;137:1117–1119
  11. Jacobson DM , Thirkill CE , Tipping SJ . A clinical triad to diagnose paraneoplastic retinopathy . Ann Neurol . 1990;28:162–167
  12. Keltner JL , Thirkill CE . Cancer-associated retinopathy vs recoverin-associated retinopathy [editorial] . Am J Ophthalmol . 1998;126:296–302
  13. Weleber RG . The effect of age on human cone and rod Ganzfeld electroretinograms . Invest Ophthalmol Vis Sci . 1981;20:392–399
  14. Weleber RG , Eisner A . Retinal function and physiological studies . In:  Newsome DA editors. Retinal dystrophies and degenerations . New York, New York: Raven Press; 1988;p. 21–69
  15. Marmor MF , Zrenner E  Standardization Committee of the International Society for Clinical Electrophysiology of Vision (ISCEV) . Standard for clinical electroretinography (1994 update) . Doc Ophthalmol . 1995;89:199–210
  16. Marmor MF , Hood DC , Keating D , Kondo M , Seeliger MW , Miyake Y . Guidelines for basic multifocal electroretinography (mfERG) . Doc Ophthalmol . 2003;106:105–115
  17. Guy J , Aptsiauri N . Treatment of paraneoplastic visual loss with intravenous immunoglobulin (report of 3 cases) . Arch Ophthalmol . 1999;117:471–477
  18. Gorczyca WA , Ejma M , Witkowska D , et al.   Retinal antigens are recognized by antibodies present in sera of patients with multiple sclerosis . Ophthalmic Res . 2004;36:120–123
  19. Gitlits VM , Toh BH , Sentry JW . Disease association, origin, and clinical relevance of autoantibodies to the glycolytic enzyme enolase . J Investig Med . 2001;49:138–145
  20. Pancholi V . Multifunctional alpha-enolase (its role in diseases) . Cell Mol Life Sci . 2001;58:902–920
  21. Maruyama I , Ohguro H , Ikeda Y . Retinal ganglion cells recognized by serum autoantibody against γ-enolase found in glaucoma patients . Invest Ophthalmol Vis Sci . 2000;41:1657–1665
  22. Ikeda Y , Maruyama I , Nakazawa M , Ohguro H . Clinical significance of serum antibody against neuron-specific enolase in glaucoma patients . Jpn J Ophthalmol . 2002;46:13–17
  23. Adamus G , Amundson D , Seigel GM , Machnicki M . Anti-enolase-alpha autoantibodies in cancer-associated retinopathy (epitope mapping and cytotoxicity on retinal cells) . J Autoimmun . 1998;11:671–677
  24. Adamus G , Machnicki M , Seigel GM . Apoptotic retinal cell death induced by antirecoverin autoantibodies of cancer-associated retinopathy . Invest Ophthalmol Vis Sci . 1997;38:283–291
  25. Adamus G . Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy . Autoimmun Rev . 2003;2:63–68
  26. Maruyama I , Maeda T , Okisaka S , Mizukawa A , Nakazawa M , Ohguro H . Autoantibody against neuron-specific enolase found in glaucoma patients causes retinal dysfunction in vivo . Jpn J Ophthalmol . 2002;46:1–12
  27. Milam AH , Dacey DM , Dizhoor AM . Recoverin immunoreactivity in mammalian cone bipolar cells . Vis Neurosci . 1993;10:1–12
  28. Ren G , Adamus G . Cellular targets of anti-alpha-enolase autoantibodies of patients with autoimmune retinopathy . J Autoimmun . 2004;23:161–167
  29. Cogan DG , Kuwabara T , Currie J , Kattah J . [Paraneoplastic retinopathy simulating cone dystrophy with achromatopsia] . Klin Monatsbl Augenheilkd . 1990;197:156–158
  30. Campo E , Brunier MN , Merino MJ . Small cell carcinoma of the endometrium with associated ocular paraneoplastic syndrome . Cancer . 1992;69:2283–2288
  31. Jacobson DM , Thirkill CE . Paraneoplastic cone dysfunction (an unusual visual remote effect of cancer) . Arch Ophthalmol . 1995;113:1580–1582
  32. Dot C, Guigay J, Adamus G. Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung. Am J Ophthalmol. forthcoming.

 Supported by a grant from the National Institutes of Health (EY13053), an unrestricted grant from Research to Prevent Blindness, New York, New York, and The Foundation Fighting Blindness, Owings Mills, Maryland.

PII: S0002-9394(05)00002-4

doi: 10.1016/j.ajo.2004.12.104

American Journal of Ophthalmology
Volume 139, Issue 5 , Pages 780-794 , May 2005

Article Tools

* Image Usage & Resolution