American Journal of Ophthalmology
Volume 139, Issue 6 , Pages 1028-1034 , June 2005

Incidence of Cytomegalovirus (CMV) Retinitis in Second Eyes of Patients With the Acquired Immune Deficiency Syndrome and Unilateral CMV Retinitis

  • John H. Kempen, MD, PhD

      Affiliations

    • Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
    • Corresponding Author InformationInquiries to John H. Kempen, MD, PhD, 550 North Broadway, Suite 700, Baltimore, MD 21205; Fax: (410) 955-0629
    • ,
  • Douglas A. Jabs, MD, MBA

      Affiliations

    • Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
    • ,
  • Laura A. Wilson, ScM

      Affiliations

    • Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
    • ,
  • James P. Dunn, MD

      Affiliations

    • Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Sheila K. West, PhD

      Affiliations

    • Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland

,Accepted 4 January 2005.

References 

  1. Burke M , Yust I , Katlama C , et al.   Cytomegalovirus retinitis in patients with AIDS in Europe. AIDS in Europe Study Group . Eur J Clin Microbiol Infect Dis . 1997;16:876–882
  2. Gallant JE , Moore RD , Richman DD , Keruly J , Chaisson RE . Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group . J Infect Dis . 1992;166:1223–1227
  3. Hoover DR , Saah AJ , Bacellar H , et al.   Clinical manifestations of AIDS in the era of pneumocystis prophylaxis. Multicenter AIDS Cohort Study . N Engl J Med . 1993;329:1922–1926
  4. Hoover DR , Peng Y , Saah A , et al.   Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression . Arch Ophthalmol . 1996;114:821–827
  5. Holtzer CD , Jacobson MA , Hadley WK , et al.   Decline in the rate of specific opportunistic infections at San Francisco General Hospital, 1994–1997 . AIDS . 1998;12:1931–1933
  6. Palella FJ , Delaney KM , Moorman AC , et al.   HIV Outpatient Study Investigators. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection . N Engl J Med . 1998;338:853–860
  7. Jabs DA . Ocular manifestations of HIV infection . Trans Am Ophthalmol Soc . 1995;93:623–683
  8. Kempen JH , Jabs DA . Ocular complications of HIV infection . In:  Johnson GJ ,  Minassian DC ,  Weale R ,  West SK editor. The epidemiology of eye diseases . London: Arnold; 2003;p. 318–340
  9. Jabs DA , Van Natta M , Kempen JH , et al.   Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy . Am J Ophthalmol . 2002;133:48–61
  10. Kempen JH , Jabs DA , Dunn JP , West SK , Tonascia J . Retinal detachment risk in cytomegalovirus retinitis related to the acquired immunodeficiency syndrome . Arch Ophthalmol . 2001;119:33–40
  11. Kempen JH , Jabs DA , Wilson LA , Dunn JP , West SK , Tonascia JA . Risk of vision loss in patients with cytomegalovirus retinitis and the acquired immunodeficiency syndrome . Arch Ophthalmol . 2003;121:466–476
  12. Musch DC , Martin DF , Gordon JF , Davis MD , Kuppermann BD  The Ganciclovir Implant Study Group . Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant . N Engl J Med . 1997;337:83–90
  13. Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group . Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. 4. Visual outcomes . Ophthalmology . 1994;101:1250–1261
  14. Martin DF , Parks DJ , Mellow SD , et al.   Treatment of cytomegalovirus retinitis with an intraocular sustained- release ganciclovir implant. A randomized controlled clinical trial . Arch Ophthalmol . 1994;112:1531–1539
  15. Martin DF , Kuppermann BD , Wolitz RA , et al.   Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant . N Engl J Med . 1999;340:1063–1070
  16. Kempen JH , Jabs DA , Wilson LA , Dunn JP , West SK , Tonascia J . Mortality risk for patients with cytomegalovirus retinitis and acquired immune deficiency syndrome . Clin Infect Dis . 2003;37:1365–1373
  17. Nguyen QD , Kempen JH , Bolton SG , Dunn JP , Jabs DA . Immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis after highly active antiretroviral therapy . Am J Ophthalmol . 2000;129:634–639
  18. Centers for Disease Control . Current trends update on acquired immune deficiency syndrome (AIDS)-United States . Morb Mortal Wkly Rep . 1982;31:507–508 513–514
  19. Centers for Disease Control and Prevention . Revision of the case definition of acquired immunodeficiency syndrome for national reporting—United States . Morb Mortal Wkly Rep . 1985;34:373–375
  20. Centers for Disease Control and Prevention . Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome . Morb Mortal Wkly Rep . 1987;36(Suppl):S1–S15
  21. Centers for Disease Control and Prevention . 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults . Morb Mortal Wkly Rep . 1992;41:1–19
  22. Holland GN , Buhles WC , Mastre B , Kaplan HJ  UCLA CMV Retinopathy Study Group . A controlled retrospective study of ganciclovir treatment for cytomegalovirus retinopathy. Use of a standardized system for the assessment of disease outcome . Arch Ophthalmol . 1989;107:1759–1766
  23. Jabs DA , Bolton SG , Dunn JP , Palestine AG . Discontinuing anticytomegalovirus therapy in patients with immune reconstitution after combination antiretroviral therapy . Am J Ophthalmol . 1998;126:817–822
  24. Kaplan JE , Masur H , Holmes KK . Guidelines for preventing opportunistic infections among HIV-infected persons-2002. Recommendations of the U.S. Public Health Service and the Infectious Diseases Society of America . MMWR Recomm Rep . 2002;51:1–52
  25. Kaplan DL , Meier P . Non-parametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457–481
  26. Cox DR , Oakes D . Analysis of survival data . London: Chapman & Hall; 1984;
  27. Lin DY , Wei LJ . The robust inference for the Cox proportional hazards model . J Am Stat Association . 1989;84:1074–1078

 Supported in part by grants EY00386 and EY07127 (J.H.K.) and EY10268 and EY00405 (D.A.J.).

PII: S0002-9394(05)00010-3

doi: 10.1016/j.ajo.2005.01.005

American Journal of Ophthalmology
Volume 139, Issue 6 , Pages 1028-1034 , June 2005

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