Central Visual Function and the NEI-VFQ-25 Near and Distance Activities Subscale Scores in People with Type 1 and 2 Diabetes

Cusick, Michael; Sangiovanni, John Paul; Chew, Emily Y.; Csaky, Karl G.; Hall-Shimel, Katherine; Reed, George F.; Caruso, Rafael C.; Ferris, Frederick L.

doi:10.1016/j.ajo.2005.01.008

« Previous Next »American Journal of Ophthalmology
Volume 139, Issue 6 , Pages 1042-1050, June 2005

Central Visual Function and the NEI-VFQ-25 Near and Distance Activities Subscale Scores in People with Type 1 and 2 Diabetes

Presented at the Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, Florida, May 2001.

Michael Cusick, MD
- Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, Maryland.
- Howard Hughes Medical Institute—National Institutes of Health Research Scholars Program, Bethesda, Maryland.
- Inquiries to Emily Y. Chew, MD, National Institutes of Health, Building 10, CRC, Room 3-2531, 10 Center Drive, MSC 1204, Bethesda, MD 20892-1204; fax: (301) 496-7295
John Paul Sangiovanni, ScD
- Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, Maryland.
Emily Y. Chew, MD
- Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, Maryland.
Karl G. Csaky, MD, PhD
- Office of the Scientific Director, Bethesda, Maryland.
Katherine Hall-Shimel, RN, COT
- Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, Maryland.
George F. Reed, PhD
- Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, Maryland.
Rafael C. Caruso, MD
- Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, Maryland
Frederick L. Ferris III, MD
- Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, Maryland.

Accepted 5 January 2005.

Purpose

To investigate relationships between clinical measures of central visual function and NEI-VFQ-25 Near and Distance Activities subscales in patients with diabetic retinopathy.

Design

Clinic-based, cross-sectional, observational study.

Methods

The NEI-VFQ-25 was administered to 170 people with type 1 or 2 diabetes before an ocular examination that included visual acuity, contrast sensitivity, and central visual fields. Multiple linear regression and exact multiple logistic regression were used to assess the relationship between poor acuity (<69 letters), poor contrast sensitivity (<1.5 log units), and abnormal visual fields (mean deviation ≤ −5dB) and NEI-VFQ-25 subscale scores.

Results

Final multivariable linear models explained a β = 4.7 letter difference (P ≤ .001) for each 25-point Near Activities subscale score difference. Similar effects were observed for the Distance Activities subscale, although the magnitudes of regression and partial correlation coefficients were lower (β = 3.3 letters, P ≤ .01). Final logistic regression models on abnormal clinical categories of central visual function demonstrated relationships only with the Near Activities subscale. For a 1-point change in Near Activities subscale score, the odds of obtaining a poor score for visual acuity, central visual fields, and contrast sensitivity changed by 0.08 (P ≤ .001), 0.07 (P ≤ .05), and 0.12 (P ≤ .001), respectively.

Conclusions

NEI-VFQ-25 Near and Distance Activities subscales demonstrate utility as measures of central visual function in persons with type 1 or 2 diabetes. Low scores on the NEI-VFQ-25 may reflect poor central visual fields and contrast sensitivity in addition to poor visual acuity.