Systemic Markers of Inflammation, Endothelial Dysfunction, and Age-Related Maculopathy

Klein, Ronald; Klein, Barbara E.K.; Knudtson, Michael D.; Wong, Tien Yin; Shankar, Anoop; Tsai, Michael Y.

doi:10.1016/j.ajo.2005.01.051

« Previous Next »American Journal of Ophthalmology
Volume 140, Issue 1 , Pages 35.e1-35.e12, July 2005

Systemic Markers of Inflammation, Endothelial Dysfunction, and Age-Related Maculopathy

Ronald Klein, MD, MPH
- Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, Madison, Wisconsin
- Inquiries to Ronald Klein, MD, MPH, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, 460 WARF, Madison, WI 53726; fax: (608) 263-0279
Barbara E.K. Klein, MD, MPH
- Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, Madison, Wisconsin
Michael D. Knudtson, MS
- Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, Madison, Wisconsin
Tien Yin Wong, MD, PhD
- Department of Ophthalmology, University of Melbourne, East Melbourne, Australia
Anoop Shankar, MD, MPH
- Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, Madison, Wisconsin
Michael Y. Tsai, PhD
- Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota

Accepted 29 January 2005. published online 06 June 2005.

Purpose

To examine the association of systemic markers of inflammatory disease and endothelial dysfunction with age-related maculopathy (ARM).

Design

(1) Nested case-control analysis of prevalent ARM and (2) prospective analyses of incident ARM in a random sample of a population-based cohort.

Methods

Standardized protocols for blood collection, measurement of markers, administration of a questionnaire, and gradings of stereoscopic color fundus photography to determine ARM were used. Standard univariate and multivariate analyses were performed. participants: Included in the nested case-control study were 188 cases with moderate to advanced ARM and 195 controls matched for age, gender, and current smoking status at a baseline examination from 1988 to 1990, and living in Beaver Dam, Wisconsin. Included in the prospective analyses as a random sample of 321 persons were those who participated in a 5-year and/or 10-year follow-up. main outcome measures: Prevalent and incident ARM.

Results

Serum C-reactive protein, amyloid A, interleukin-6, tumor necrosis factor-α, intracellular adhesion molecule, E-selectin, folate, and Chlamydia pneumoniae IgG antibody were not associated with either prevalent or incident ARM.