American Journal of Ophthalmology
Volume 141, Issue 1 , Pages 54-61.e1 , January 2006

Microdissection Genotyping Analysis of the Effect of Intraarterial Cytoreductive Chemotherapy in the Treatment of Lacrimal Gland Adenoid Cystic Carcinoma

  • David T. TSE, MD

      Affiliations

    • Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida
    • Corresponding Author InformationInquiries to David T. Tse, MD, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136; fax: (305) 326-6443
  • ,
  • Sydney D. Finkelstein, MD

      Affiliations

    • RedPath Integrated Pathology Inc, Pittsburgh, Pennsylvania
  • ,
  • Pasquale Benedetto, MD

      Affiliations

    • Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, Florida
  • ,
  • Sander Dubovy, MD

      Affiliations

    • Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida
  • ,
  • Joyce Schiffman, MS

      Affiliations

    • Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida
  • ,
  • William J. Feuer, MS

      Affiliations

    • Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida

,Accepted 1 September 2005.

References 

  1. Buendia MA . Genetics of hepatocellular carcinoma . Semin Cancer Biol . 2000;10:185–200
  2. Pineau P , Buendia MA . Studies of genetic defects in hepatocellular carcinoma (recent outcomes and new challenges) . J Hepatol . 2000;33:152–156
  3. Finkelstein SD , Marsh W , Demetris AJ , et al.   Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma . Hepatology . 2003;37:871–879
  4. Rolston R , Sasatomi E , Hunt J , et al.   Distinguishing de novo second cancer formation from tumor recurrence (mutational fingerprinting by microdissection genotyping) . J Mol Diagn . 2001;3:129–132
  5. Cheung O , Kandil H , Moser AJ , et al.   Primary duodenal carcinoma showing divergent growth patterns as determined by microdissection-based mutational genotyping . Arch Pathol Lab Med . 2003;127:861–864
  6. Sasatomi E , Finkelstein SD , Woods JD , et al.   Comparison of accumulated allele loss between primary tumor and lymph node metastasis in stage II non–small cell lung carcinoma (implications for the timing of lymph node metastasis and prognostic value) . Cancer Research . 2002;62:2681–2689
  7. Finkelstein SD , Przygodzki R , Swalsky PA . Microdissection-based p53 genotyping (concepts for molecular testing) . Mol Diagn . 1998;3:179–191
  8. Finkelstein SD , Mohan D , Hamilton RL , et al.   Microdissection-based genotyping assists discrimination of reactive gliosis from glioma . Am J Clin Pathol . 2004;121:671–678
  9. Pollack IF , Finkelstein SD , Woods J , et al.   Expression of p53 and prognosis in children with malignant gliomas (Children’s Cancer Group) . N Engl J Med . 2002;346:420–427
  10. Rubin MA . Use of laser capture microdissection, cDNA microarrays, and tissue microarrays in advancing our understanding of prostate cancer . J Pathol . 2001;195:80–86
  11. Miyai K , Furugen Y , Matsumoto T , et al.   Loss of heterozygosity analysis in uterine cervical adenocarcinoma . Gynecol Oncol . 2004;94:115–120
  12. Iacobuzio-Donahue CA , van der Heijden MS , Baumgartner MR , et al.   Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss . Cancer Res . 2004;64:871–875
  13. Fernando HC , Sasatomi E , Christie NA , et al.   Comparison of mutational changes in involved N1 lymph nodes with those in primary tumors in stage II non–small cell lung cancer (a pilot study) . J Thorac Cardiovasc Surg . 2004;127:87–91
  14. Nakayama S , Nakayama K , Takebayashi Y , et al.   Allelotypes as potential prognostic markers in ovarian carcinoma treated with cisplatin-based chemotherapy . Int J Mol Med . 2003;11:621–625
  15. Park S , Kim SW , Kim SH , et al.   Loss of heterozygosity in ampulla of Vater neoplasms during adenoma-carcinoma sequence . Anticancer Res . 2003;23:2955–2959
  16. Ishikawa Y , Furuta R , Miyoshi T , et al.   Loss of heterozygosity and the smoking index increase with decrease in differentiation of lung adenocarcinomas (etiologic implications) . Cancer Lett . 2002;187:47–51
  17. Jiang WW , Fujii H , Shirai T , et al.   Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity . Cancer . 2001;92:2349–2356
  18. Shao JY , Huang XM , Yu XJ , et al.   Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma . Anticancer Res . 2001;21:3021–3029
  19. Mohan D , Finkelstein SD , Swalsky PA , et al.   Microdissection genotyping of gliomas (therapeutic and prognostic considerations) . Mod Pathol . 2004;17:1346–1358
  20. Marsh JW , Finkelstein SD , Demetris AJ , et al.   Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival . Liver Transpl . 2003;9:664–671
  21. Williams H . Molecular pathogenesis of oral squamous carcinoma . J Clin Pathol Mol Pathol . 2000;53:165–172
  22. Mao L , Lee DJ , Tockman MS , et al.   Microsatellite alterations as clonal markers for the detection of human cancer . Proc Natl Acad Sci U S A . 1994;91:9871–9875
  23. Hunt JL , Swalsky P , Sasatomi E , et al.   A microdissection and molecular genotyping assay to confirm the identity of tissue floaters in paraffin-embedded tissue blocks . Arch Pathol Lab Med . 2003;127:213–217
  24. Miyai K , Furugen Y , Matsumoto T , et al.   Loss of heterozygosity analysis in uterine cervical adenocarcinoma . Gynecol Oncol . 2004;94:115–120
  25. Iacobuzio-Donahue CA , van der Heijden MS , Baumgartner MR , et al.   Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss . Cancer Res . 2004;64:871–875
  26. Fernando HC , Sasatomi E , Christie NA , et al.   Comparison of mutational changes in involved N1 lymph nodes with those in primary tumors in stage II non–small cell lung cancer (a pilot study) . J Thorac Cardiovasc Surg . 2004;127:87–91
  27. Nakayama S , Nakayama K , Takebayashi Y , et al.   Allelotypes as potential prognostic markers in ovarian carcinoma treated with cisplatin-based chemotherapy . Int J Mol Med . 2003;11:621–625
  28. Park S , Kim SW , Kim SH , et al.   Loss of heterozygosity in ampulla of Vater neoplasms during adenoma-carcinoma sequence . Anticancer Res . 2003;23:2955–2959
  29. Ishikawa Y , Furuta R , Miyoshi T , et al.   Loss of heterozygosity and the smoking index increase with decrease in differentiation of lung adenocarcinomas (etiologic implications) . Cancer Lett . 2002;187:47–51
  30. Jiang WW , Fujii H , Shirai T , et al.   Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity . Cancer . 2001;92:2349–2356
  31. Shao JY , Huang XM , Yu XJ , et al.   Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma . Anticancer Res . 2001;21:3021–3029
  32. Finkelstein SD , Marsh W , Demetris AJ , et al.   Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma . Hepatology . 2003;37:871–879
  33. Marsh JW , Finkelstein SD , Demetris AJ , et al.   Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival . Liver Transpl . 2003;9:664–671

 See accompanying Article on page 44 and Brief Report on page 187.Supported in part by NIH center grant P30-EY014801; an unrestricted grant from Research to Prevent Blindness Inc, New York, New York, and a grant from the Plum Foundation, Los Angeles, California.This manuscript is based on a thesis that was prepared in partial fulfillment of the requirements for membership in the American Ophthalmological Society.

PII: S0002-9394(05)01010-X

doi: 10.1016/j.ajo.2005.09.002

American Journal of Ophthalmology
Volume 141, Issue 1 , Pages 54-61.e1 , January 2006