American Journal of Ophthalmology
Volume 142, Issue 1 , Pages 17-30.e8 , July 2006

Autologous Translocation of the Choroid and Retinal Pigment Epithelium in Age-related Macular Degeneration

  • Antonia M. Joussen, MD

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne
    • Corresponding Author InformationInquiries to Antonia M. Joussen, MD, University of Cologne, Department of Vitreoretinal Surgery, Joseph Stelzmannstrasse 9, Cologne 50931, Germany
    • ,
  • Florian M.A. Heussen, BS

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne
    • ,
  • Sandra Joeres, MD

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne
    • ,
  • Helene Llacer, MD

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne
    • ,
  • Beate Prinz, OD

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne
    • ,
  • Klaus Rohrschneider, MD

      Affiliations

    • Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    • ,
  • Kristel J.M. Maaijwee, MD

      Affiliations

    • Rotterdam Eye Hospital, Rotterdam, The Netherlands
    • ,
  • Jan van Meurs, MD

      Affiliations

    • Rotterdam Eye Hospital, Rotterdam, The Netherlands
    • ,
  • Bernd Kirchhof, MD

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne

,Accepted 31 January 2006.

References 

  1. Sarks SH . Aging and degeneration in the macular region (A Clinico-Pathological Study) . Br J Ophthalmol . 1976;60:324–341
  2. Ryan SJ . Subretinal neovascularizationIn . In:  Ryan SJ editors. Retina . Vol. 2: St Louis, Missouri: CV Mosby; 1989;p. 107–125
  3. Sarks JS , Sarks SH , Killingworth MC . Evolution of geographic atrophy of the . Eye . 1988;2:552–577
  4. Schatz H , McDonald R . Atrophic macular degeneration (rate of spread of geographic atrophy and visual loss) . Ophthalmology . 1989;96:1541–1551
  5. Bressler NM , Bressler SB , Fine SL . Age-related macular degeneration . Surv Ophthalmol . 1988;32:375–413
  6. Strahlman ER , Fine SL , Hillis A . The second eye of patients with senile macular degeneration . Arch Ophthalmol . 1983;101:1191–1193
  7. Coffey AJH , Brownstein S . The prevalence of macular drusen in postmortem eyes . Am J Ophthalmol . 1986;102:164–171
  8. Cullinan TM . The epidemiology of blindnessIn . In:  Miller S editors. Clinical ophthalmology . Bristol: Wright; 1987;p. 571–578
  9. Gibson JM , Rosenthal AR , Lavery J . A study of the prevalence of eye disease in the elderly in an English community . Trans Ophthalmol Soc UK . 1985;104:196–203
  10. Kahn HA , Moorhead HB . In: Statistics on blindness in the model reporting area, 1969–1970. USDHEW publication . Washington, DC: National Institutes of Health; 1973;p. 73–427
  11. Leibowitz H , Krueger DE , Maunder LR , et al.   The Framingham Eye Study monograph (an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration and visual acuity in a general population of 2631 adults, 1973–1975) . Surv Ophthalmol . 1984;25:335–610
  12. Adelberg DA , del Priore LV , Kaplan HJ . Surgery for subfoveal membranes in myopia, angioid streaks, and other disorders . Retina . 1995;15:198–205
  13. Hudson HL , Frambach DA , Lopez PF . Relation of the functional and structural fundus changes after submacular surgery for neovascular age-related macular degeneration . Br J Ophthalmol . 1995;79:417–423
  14. Thomas MA , Grand MG , Williams DF , Lee CM , Pesin SR , Lowe MA . Surgical management of subfoveal choroidal neovascularization . Ophthalmology . 1992;99:952–968
  15. Scheider A , Gündisch O , Kampik A . Surgical extraction of subfoveal choroidal new vessels and submacular haemorrhage in age-related macular degeneration (results of a prospective study) . Graefes Arch Clin Exp Ophthalmol . 1999;237:10–15
  16. Submacular Surgery Trial Research Group . Surgery for subfoveal choroidal neovascularization in age-related macular degeneration: ophthalmic findings. SST report No. 11 . Ophthalmology . 2004;111:1967–1980
  17. Berger AS , Kaplan HJ . Clinical experience with the surgical removal of subfoveal neovascular membranes . Ophthalmology . 1992;99:969–975
  18. Eckardt C . Chirurgische Entfernung von submakulären Neovaskularisationsmembranen . Ophthalmologe . 1996;93:688–693
  19. Lambert HM , Capone AJ , Aaberg TM , Strenberg PJ , Mandell BA , Lopez PF . Surgical excision of subfoveal neovascular membranes in age-related macular degeneration . Am J Ophthalmol . 1992;113:257–262
  20. Thomas JW , Grossniklaus HE , Lambert HM , Aaberg TM , L’Hernault N . Ultrastructural features of surgically excised idiopathic subfoveal . Retina . 1993;13:93–98
  21. Thomas MA , Dickinson JD , Melberg NS , Ibanez HE , Dhaliwal RS . Visual results after surgical removal of subfoveal choroidal membranes . Ophthalmology . 1994;101:1384–1396
  22. Lappas A , Weinberger AWA , Foerster AMH , Kube TH , Kirchhof B . Iris pigment epithelium translocation in age related macular degeneration . Graefes Arch Exp Clin Ophthalmol . 2000;238:631–641
  23. Thumann G , Aisenbrey S , Schraermeyer U , et al.   Transplantation of autologous iris pigment epithelium after removal of choroidal neovascular membranes . Arch Ophthalmol . 2000;118:1350–1355
  24. Wolf S , Lappas A , Weinberger A , Kirchhof B . Macular translocation for surgical management of subfoveal choroidal neovascularizations in patients with AMD (first results) . Graefes Arch Clin Exp Ophthalmol . 1999;237:51–57
  25. Eckardt C , Eckardt U , Conrad HJ . Macular rotation with and without counter-rotation of the globe in patients with age-related macular degeneration . Graefes Arch Clin Exp Ophthalmol . 1999;237:313–325
  26. Aisenbrey S , Lafaut BA , Szurman P , et al.   Macular translocation with 360 degrees retinotomy for exudative age-related macular degeneration . Arch Ophthalmol . 2002;120:451–459
  27. Cahill MT , Stinnett SS , Banks AD , et al.   Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degeneration . Ophthalmology . 2005;112:144–151
  28. Toth CA , Lapolice DJ , Banks AD , Stinnett SS . Improvement in near visual function after macular translocation surgery with 360-degree peripheral retinectomy . Graefes Arch Clin Exp Ophthalmol . 2004;242:541–548
  29. Ninomiya Y , Lewis JM , Hasegawa T , Tanoi Y . Retinotomy and foveal translocation for surgical management of subfoveal choroidal neovascular membranes . Am J Ophthalmol . 1996;122:613–621
  30. Algvere PV , Berglin L , Gouras P , Sheng Y . Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization . Graefes Arch Clin Esp Ophthalmol . 1994;232:707–716
  31. Algvere PV , Berglin L , Gouras P , Sheng Y , Kopp ED . Transplantation of RPE in age-related macular degeneration (observations in disciform lesions and dry RPE atrophy) . Graefes Arch Clin Exp Ophthalmol . 1997;235:149–158
  32. Lappas A , Foerster AM , Weinberger AW , Coburger S , Schrage NF , Kirchhof B . Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration (long-term results) . Graefes Arch Clin Exp Ophthalmol . 2004;242:638–647
  33. Peyman GA , Blinder KJ , Paris CJ , Alturki W , Nelson NC , Desai U . A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring . Ophthalmic Surg . 1991;22:102
  34. van Meurs JC , ter Averst E , Croxen R , Hofland L , van Hagen PM . Comparison of the growth potential of retinal pigment epithelial cells obtained during vitrectomy in patients with age-related macular degeneration or complex retinal detachment . Graefes Arch Clin Exp Ophthalmol . 2004;242:442–443
  35. Stanga PE , Kychenthal A , Fitzke FW , et al.   Retinal pigment epithelium translocation after choroidal neovascular membrane removal in age-related macular degeneration . Ophthalmology . 2002;109:1492–1498
  36. Stanga PE , Kychenthal A , Fitzke FW , et al.   Functional assessment of the native retinal pigment epithelium after the surgical excision of subfoveal choroidal neovascular membranes type II (preliminary results) . Int Ophthalmol . 2001;23:309–316
  37. Chylack LT , Wolfe JK , Singer DM , et al.   The Lens Opacities Classification System III (the Longitudinal Study of Cataract Study Group) . Arch Ophthalmol . 1993;111:831–836
  38. Stifter E , Konig F , Lang T , et al.   Reliability of a standardized reading chart system (variance component analysis, test-retest and inter-chart reliability) . Graefes Arch Clin Exp Ophthalmol . 2004;242:31–39
  39. Radner W , Willinger U , Obermayer W , Mudrich C , Velikay-Parel M , Eisenwort B . Eine neue Lesetafel zur gleichzeitigen Bestimmung von Lesevisus und Lesegeschwindigkeit . Klin Monatsbl Augenheilkd . 1998;213:174–181
  40. Holz FG , Bellmann C , Rohrschneider K , Burk ROW , Völcker HE . Simultaneous confocal scanning laser fluorscein- and indocaynine green angiography . Am J Ophthalmol . 1998;125:227–236
  41. Schmitz-Valckenberg S , Bültmann S , Deyhaupt J , Bindewald A , Holz FG , Rohrschneider K . Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration . Invest Ophthalmol Vis Sci . 2004;45:4470–4476
  42. Barbazetto I , Burdan A , Bressler NM , et al.  Treatment of Age-related Macular Degeneration with Photodynamic Therapy Study Group; Verteporfin in Photodynamic Therapy Study Group   Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment—TAP and VIP report No. 2 . Arch Ophthalmol . 2003;121:1253–1268
  43. Rohrschneider K , Becker M , Schumacher N , Fendrich T , Volcker HE . Normal values for fundus perimetry with the scanning laser ophthalmoscope . Am J Ophthalmol . 1998;126:52–58
  44. Rohrschneider K , Fendrich T , Becker M , Krastel H , Kruse FE , Volcker HE . Static fundus perimetry using the scanning laser ophthalmoscope with an automated threshold strategy . Graefes Arch Clin Exp Ophthalmol . 1995;233: 743–739
  45. van Meurs JC , van Den Biesen PR . Autologous retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration (short-term follow-up) . Am J Ophthalmol . 2003;136:688–695
  46. Bellmann C , Rubin CS , Kabanarou SA , Bird AS , Fitzke WF . Fundus autofluorescence imaging compared with different confocal scanning laser ophthalmoscopes . Br J Ophthalmol . 2003;87:1381–1386
  47. Gragoudas ES , Adamis AP , Cunningham ET , Feinsod M , Guyer DR . VEGF inhibition study in ocular neovascularization (pegaptanib for neovascular age-related macular degeneration) . N Engl J Med . 2004;351:2805–2816
  48. Treatment of Age-related Macular Degeneration With Photodynamic Therapy (TAP) Study Group . Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one year results of 2 randomized clinical trials—TAP report No. 1 . Arch Ophthalmol . 1999;117:1329–1345
  49. Verteporfin in Photodynamic Therapy Study Group . Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization—verteporfin in photodynamic therapy report No. 2 . Am J Ophthalmol . 2001;131:541–560
  50. Bressler NM , Bressler SB , Childs AL , et al.  Submacular Surgery Trials (SST) Research Group   Surgery for hemorrhagic choroidal neovascular lesions of age-related macular degeneration: ophthalmic findings. SST report No. 13 . Ophthalmology . 2004;111:1993–2006
  51. Bressler NM , Bressler SB , Hawkins BS , Marsh MJ , Sternberg P , Thomas MA  Submacular Surgery Trials Pilot Study Investigators . Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: I. Ophthalmic outcomes submacular surgery trials pilot study report No. 1 . Am J Ophthalmol . 2000;130:387–407
  52. Castellarin AA , Nasir M , Sugino IK , Zarbin MA . Progressive presumed choriocapillaris atrophy after surgery for age-related macular degeneration . Retina . 1998;18:143–149
  53. Ormerod LD , Puklin JE , Frank RN . Long-term outcomes after the surgical removal of advanced subfoveal neovascular membranes in age-related macular degeneration . Ophthalmology . 1994;101:1201–1210
  54. Klein R , Klein BE , Jensen SC , Meuer SM . The five-year incidence and progression of age-related maculopathy (The Beaver Dam Eye Study) . Ophthalmology . 1997;104:7–21
  55. Majji AB , de Juan E . Retinal pigment epithelial autotransplantation (morphological changes in retina and choroid) . Graefes Arch Clin Exp Ophthalmol . 2000;238:779–791
  56. Crafoord S , Algvere PV , Kopp ED , Seregard S . Cyclosporine treatment of RPE allografts in the rabbit subretinal space . Acta Ophthalmol Scand . 2000;78:122–129
  57. Del Priore LV , Kaplan HJ , Tezel TH , Hayashi N , Berger AS , Green WR . Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration (clinicopathologic correlation) . Am J Ophthalmol . 2001;131:472–480
  58. Binder S , Krebs I , Hilgers RD , et al.   Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration (a prospective trial) . Invest Ophthalmol Vis Sci . 2004;45:4151–4160
  59. Assadoullina A , Feichtinger H , Binder S . Subfoveal neovascular membranes (histopathologic features as a predictive factor by combined subretinal surgery and autologous RPE transplantation) . (in German) Spectrum Augenheilk . 2003;17:120–173
  60. Lopez PF , Grossniklaus HE , Lambert HM , et al.   Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration . Am J Ophthalmol . 1991;112:647–656
  61. Kociok N , Joussen AM . Gene expression in normal human RPE and choroid (comparison of central versus peripheral location) . Graefes Arch Clin Exp Ophthalmol . 2006; E-pub: April 6
  62. Aisenbrey S , Lafaut B , Szurman P , et al.   Makulatranslokation mit 360 Grad Retinotomie zur Behandlung der exsudativen Makuladegeneration (funktionelle und angiographische Ergebnisse) . Ophthalmologe . 2002;99:164–170
  63. Rohrschneider K , Glück R , Becker M , et al.   Scanning laser fundus perimetry before laser photoculation of well defined choroidal neovascularization . Br J Ophthalmol . 1997;81:568–573
  64. Sunness JS , Bressler NM , Maguire MG . Scanning laser ophthalmoscopic appearance of the pattern of visual loss in age-related geographic atrophy of the macula . Am J Ophthalmol . 1995;119:143–151
  65. Melberg NS , Thomas MA , Burgess DB . The surgical removal of subfoveal choroidal neovascularization. Ingrowth site as a predictor of visual outcome . Retina . 1996;16:190–195
  66. de Juan E , Loewenstein A , Bressler NM , Alexander J . Translocation of the retina for management of subfoveal choroidal neovascularization II (a preliminary report in humans) . Am J Ophthalmol . 1998;125:635–646
  67. Abdel-Meguid A , Lappas A , Hartmann K , et al.   One year follow-up of macular translocation with 360 degree retinotomy in patients with age-related macular degeneration . Br J Ophthalmol . 2003;87:615–621

 Supported in part by the Deutsche Forschungsgemeinschaft (DFG) Jo 324/6-1 und 6-2 (Emmy Noether), Jo 324/4-1, and Ki 743/5-1, and Ki 743/2-1. The Brunnenbusch Stein Stiftung and the Glaser Stiftung sponsored patient related costs and the RetinoVit Stiftung Köln was helpful in funding necessary equipment.Supplemental Material and Video available at AJO.com.

PII: S0002-9394(06)00302-3

doi: 10.1016/j.ajo.2006.01.090

American Journal of Ophthalmology
Volume 142, Issue 1 , Pages 17-30.e8 , July 2006

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