American Journal of Ophthalmology
Volume 142, Issue 3 , Pages 400-404 , September 2006

Intraoperative Mitomycin and Corneal Endothelium After Photorefractive Keratectomy

  • Alberto J. Morales, MD

      Affiliations

    • Codet-Aris Vision Institute, Tijuana, Mexico
  • ,
  • David Zadok, MD

      Affiliations

    • Codet-Aris Vision Institute, Tijuana, Mexico
    • Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Rolando Mora-Retana, MD

      Affiliations

    • Codet-Aris Vision Institute, Tijuana, Mexico
  • ,
  • Eduardo Martínez-Gama, MD

      Affiliations

    • Codet-Aris Vision Institute, Tijuana, Mexico
  • ,
  • Nora E. Robledo, OD

      Affiliations

    • Codet-Aris Vision Institute, Tijuana, Mexico
  • ,
  • Arturo S. Chayet, MD

      Affiliations

    • Codet-Aris Vision Institute, Tijuana, Mexico
    • Corresponding Author InformationInquiries to Arturo S. Chayet, MD, Codet-Aris Vision Institute, Padre Kino 10159, Tijuana, BC, 22032, Mexico

,Accepted 13 April 2006.

References 

  1. Holladay JT , Dudeja DR , Chang J . Functional vision and corneal changes after laser in situ keratomileusis determined by contrast sensitivity, glare testing, and corneal topography . J Cataract Refract Surg . 1999;25: 663-639
  2. O’Brart DP , Lohmann CP , Klonos G , et al.   The effects of topical corticosteroids and plasmin inhibitors on refractive outcome, haze, and visual performance after photorefractive keratectomy (a prospective, randomized, observer-masked study) . Ophthalmology . 1994;101:1565–1574
  3. Gartry DS , Kerr Muir MG , Lohmann CP , et al.   The effect of topical corticosteroids on refractive outcome and corneal haze after photorefractive keratectomy (a prospective, randomized, double-blind trial) . Arch Ophthalmol . 1992;110:944–952
  4. Talamo JH , Gollamudi S , Green WR , et al.   Modulation of corneal wound healing after excimer laser keratomileusis using topical mitomycin C and steroids . Arch Ophthalmol . 1991;109:1141–1146
  5. Sugar A . Who should receive mitomycin C after pterygium surgery? . Ophthalmology . 1992;99:1645–1646
  6. Palmer SS . Mitomycin as adjunct chemotherapy with trabeculectomy . Ophthalmology . 1991;98:317–321
  7. Mahar PS , Nwokora GE . Role of mitomycin C in pterygium surgery . Br J Ophthalmol . 1993;77:433–435
  8. Frucht-Pery J , Rozenman J . Mitomycin C therapy for corneal intraepithelial neoplasia . Am J Ophthalmol . 1994;117:164–168
  9. Lane HA , Swale JA , Majmudar PA . Prophylactic use of mitomycin C in the management of a buttonholed LASIK flap . J Cataract Refract Surg . 2003;29:390–392
  10. Carones F , Vigo L , Scandola E , et al.   Evaluation of the prophylactic use of mitomycin C to inhibit haze formation after photorefractive keratectomy . J Cataract Refract Surg . 2002;28:2088–2095
  11. Camellin M . Laser epithelial keratomileusis with mitomycin C (indications and limits) . J Refract Surg . 2004;20:693–698
  12. Lai YH , Wang HZ , Lin CP , et al.   Mitomycin C alters corneal stromal wound healing and corneal haze in rabbits after argon-fluoride excimer laser photorefractive keratectomy . J Ocul Pharmacol Ther . 2004;20:129–138
  13. Kim TI , Pak JH , Lee SY , et al.   Mitomycin C–induced reduction of keratocytes and fibroblasts after photorefractive keratectomy . Invest Ophthalmol Vis Sci . 2004;45:2978–2984
  14. Chang SW . Early corneal edema following topical application of mitomycin C . J Cataract Refract Surg . 2004;30:1742–1750
  15. Pop M , Payette Y . Initial results of endothelial cell counts after Artisan lens for phakic eyes (an evaluation of the United States Food and Drug Administration Ophtec Study) . Ophthalmology . 2004;111:309–317
  16. Doughty MJ , Muller A , Zaman ML . Assessment of the reliability of human corneal endothelial cell–density estimates using a noncontact specular microscope . Cornea . 2000;19:148–158
  17. Bourne WM , Nelson LR , Hodge DO . Central corneal endothelial cell changes over a ten-year period . Invest Ophthalmol Vis Sci . 1997;38:779–782
  18. Landesz M , Siertsema JV , Van Rij G . Comparative study of three semiautomated specular microscopes . J Cataract Refract Surg . 1995;21:409–416
  19. Sihota R , Sharma T , Agarwal HC . Intraoperative mitomycin C and the corneal endothelium . Acta Ophthalmol Scand . 1998;76:80–82
  20. Jain S , McCally RL , Connolly PJ , et al.   Mitomycin C reduces corneal light scattering after excimer keratectomy . Cornea . 2001;20:45–49
  21. Pastor SA , Williams R , Hetherington J , et al.   Corneal endothelial cell loss following trabeculectomy with mitomycin C . J Glaucoma . 1993;2:112–113
  22. Dreyer EB , Chaturvedi N , Zurakowski D . Effect of mitomycin C and fluorouracil-supplemented trabeculectomies on the anterior segment . Arch Ophthalmol . 1995;113:578–580
  23. Derick RJ , Pasquale L , Quigley HA , et al.   Potential toxicity of mitomycin C [letter] . Arch Ophthalmol . 1991;109:1635
  24. McDermott ML , Wang J , Shin DH . Mitomycin C and the human corneal endothelium . Arch Ophthalmol . 1994;112:533–537
  25. Smith DL , Skuta GL , Lindenmuth KA , et al.   The effect of glaucoma filtering surgery on corneal endothelial cell density . Ophthalmic Surg . 1991;22:251–255
  26. Dushku N , Reid TW . Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells . Curr Eye Res . 1994;13:473–481
  27. Dorr RT . Pharmacokinetic, metabolic and drug resistance aspects of mitomycin C . Semin Oncol . 1988;15:S32–S41

PII: S0002-9394(06)00502-2

doi: 10.1016/j.ajo.2006.04.029

American Journal of Ophthalmology
Volume 142, Issue 3 , Pages 400-404 , September 2006