American Journal of Ophthalmology
Volume 142, Issue 4 , Pages 563.e1-563.e6 , October 2006

Efficacy of Oral Antiviral Prophylaxis in Preventing Ocular Herpes Simplex Virus Recurrences in Patients With and Without Self-Reported Atopy

  • Renata A. Rezende, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • Department of Ophthalmology, Federal University of Sao Paulo (UNIFESP)–R. Botucatu, Sao Paulo, Brazil
    • Corresponding Author InformationInquiries to Renata A. Rezende, MD, Rua Visconde de Silva, 321/201, Humaita, Rio de Janeiro, RJ, Brazil
    • ,
  • Tiago Bisol, MD

      Affiliations

    • Central Hospital of Brazilian Air-Force (HCA)–Rua Barão de Itapagipe, Rio de Janeiro, Brazil.
    • ,
  • Kristin Hammersmith, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Christopher J. Rapuano, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Ana Luisa H. Lima, MD, PhD

      Affiliations

    • Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
    • ,
  • Guy F. Webster, MD, PhD

      Affiliations

    • Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
    • ,
  • Juliana F. Freitas, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Peter R. Laibson, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Elisabeth J. Cohen, MD

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania

,Accepted 10 May 2006.

References 

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  2. Holland E , Schwartz G . Classification of herpes simplex virus keratitis . Cornea . 1999;18:144–154
  3. Gamus D , Romano A , Sucher E , et al.   Herpetic eye attacks: variability of circannual rhythms . Br J Ophthalmol . 1995;79:50–53
  4. Easty DL . Clinical aspects of ocular herpes simplex virus infection . In:  Darrell RW editors. Viral diseases of the eye . Philadelphia, Pennsylvania: Lea & Febiger; 1985;p. 135
  5. Liesegang TJ . Herpes simplex virus epidemiology and ocular importance . Cornea . 2001;20:1–13
  6. Simon AL , Pavan-Langston D . Long-term oral acyclovir therapy (Effect on recurrent infectious herpes simplex keratitis in patients with and without grafts) . Ophthalmology . 1996;103:1399–1404
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  10. Charles SJ , Gray JJ . Ocular herpes simplex virus infections: reduced sensitivity to acyclovir in primary disease . Br J Ophthalmol . 1990;74:286–288
  11. McLeish W , Pflugfelder SC , Crouse C , et al.   Interferon treatment of herpetic keratitis in a patient with acquired immunodeficiency syndrome . Am J Ophthalmol . 1990;109:93–95
  12. Sonkin PL , Baratz KH , Frothingham R , et al.   Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty . Ophthalmology . 1992;99:1805–1809
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  15. Asher MI , Keil U , Anderson HR , et al.   The International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods . Eur Resp J . 1995;8:483–491
  16. Baringer J , Swoveland P . Recovery of herpes simplex virus from human trigeminal ganglion . N Engl J Med . 1973;288:648–650
  17. Liesegang TJ . Ocular herpes simplex infection: pathogenesis and current therapy . Mayo Clin Proc . 1988;63:1092–1105
  18. Pavan-Langston D , Rong BL , Dunkel EC . Extraneuronal herpetic latency: animal and human corneal studies . Acta Ophthalmol . 1989;192:S135–S141
  19. Rong BL , Pavan-Langston D , Weng QP , et al.   Detection of herpes simplex virus thymidine kinase and latency-associated transcript gene sequences in human herpetic corneas by polymerase chain reaction amplification . Invest Ophthalmol Vis Sci . 1991;32:1808–1815
  20. Margolis TP , Ostler HB . Treatment of ocular disease in eczema herpeticum . Am J Ophthalmol . 1990;110:274–279
  21. Rystedt I , Strannegard I-L , Strannegard O . Infections as contributing factors to atopic dermatitis . Allergy . 1989;44:S79–S83
  22. Rezende RA , Hammersmith K , Bisol T , et al.   Comparative study of ocular HSV in patients with and without self-reported atopy . Am J Ophthalmol . 2006;141:1120–1125

PII: S0002-9394(06)00605-2

doi: 10.1016/j.ajo.2006.05.025

American Journal of Ophthalmology
Volume 142, Issue 4 , Pages 563.e1-563.e6 , October 2006

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