American Journal of Ophthalmology
Volume 142, Issue 4 , Pages 591.e1-591.e10 , October 2006

Assessment of Axonal Degeneration Along the Human Visual Pathway Using Diffusion Trace Analysis

  • Satoshi Ueki, MD

      Affiliations

    • Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    • Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, University of Niigata, Niigata, Japan
    • ,
  • Yukihiko Fujii, MD, PhD

      Affiliations

    • Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    • ,
  • Hitoshi Matsuzawa, MD, PhD

      Affiliations

    • Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    • ,
  • Mineo Takagi, MD, PhD

      Affiliations

    • Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, University of Niigata, Niigata, Japan
    • ,
  • Haruki Abe, MD, PhD

      Affiliations

    • Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, University of Niigata, Niigata, Japan
    • ,
  • Ingrid L. Kwee, MD

      Affiliations

    • Department of Neurology, University of California, Davis, California.
    • ,
  • Tsutomu Nakada, MD, PhD

      Affiliations

    • Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    • Department of Neurology, University of California, Davis, California.
    • Corresponding Author InformationInquiries to Tsutomu Nakada, MD, PhD, Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951-8585, Japan

,Accepted 18 May 2006.

References 

  1. Polyak S . Recent investigations of the infranuclear division of the visual system . In:  Klüver H editors. The vertebrate visual system . Chicago, Illinois: University of Chicago Press; 1957;p. 188–194
  2. Hoyt WF , Luis O . Visual fiber anatomy in the infrageniculate pathway of the primate . Arch Ophthalmol . 1962;68:94–106
  3. Hoyt WF , Luis O . The primate chiasm (Details of visual fiber organization studied by silver impregnation techniques) . Arch Ophthalmol . 1963;70:69–85
  4. Suzuki Y , Matsuzawa H , Nakada T . Feasibility study of single region lambda chart analysis for pyramidal tract physiology . J Neurol . 2003;250:1185–1189
  5. Suzuki Y , Matsuzawa H , Kwee IL , Nakada T . Absolute eigenvalue diffusion tensor analysis for human brain maturation . NMR Biomed . 2003;16:257–260
  6. Iwasawa T , Matoba H , Ogi A , et al.   Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis . Magn Reson Med . 1997;38:484–491
  7. Wheeler-Kingshott CA , Parker GJ , Symms MR , et al.   ADC mapping of the human optic nerve: increased resolution, coverage, and reliability with CSF-suppressed ZOOM-EPI . Magn Reson Med . 2002;47:24–31
  8. Pipe JG , Farthing VG , Forbes KP . Multishot diffusion-weighted FSE using PROPELLER MRI . Magn Reson Med . 2002;47:42–52
  9. Nakada T , Matsuzawa H , Kwee IL . Magnetic resonance axonography of the rat spinal cord . Neuroreport . 1994;5:2053–2056
  10. Nakada T , Nakayama N , Fujii Y , Kwee IL . Clinical application of three-dimensional anisotropy contrast magnetic resonance axonography (Technical note) . J Neurosurg . 1999;90:791–795
  11. Nakada T . Clinical experience on 3.0 T systems in Niigata, 1996 to 2002 . Invest Radiol . 2003;38:377–384
  12. Miller NR . Optic atrophy . In:  Miller NR editors. Walsh and Hoyt’s clinical neuro-ophthalmology . 4th ed.. Baltimore, Maryland: Williams & Wilkins; 1982;p. 329–342
  13. Ciccarelli O , Toosy AT , Hickman SJ , et al.   Optic radiation changes after optic neuritis detected by tractography-based group mapping . Hum Brain Mapp . 2005;25:308–316
  14. Pierpaoli C , Barnett A , Pajevic S , et al.   Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture . Neuroimage . 2001;13:1174–1185
  15. Watanabe T , Honda Y , Fujii Y , et al.   Three-dimensional anisotropy contrast magnetic resonance axonography to predict the prognosis for motor function in patients suffering from stroke . J Neurosurg . 2001;94:955–960
  16. Thomalla G , Glauche V , Koch MA , et al.   Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke . Neuroimage . 2004;22:1767–1774
  17. Anderson AW , Zhong J , Petroff OA , et al.   Effects of osmotically driven cell volume changes on diffusion-weighted imaging of the rat optic nerve . Magn Reson Med . 1996;35:162–167
  18. Ciccarelli O , Werring DJ , Barker GJ , et al.   A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging: evidence of Wallerian degeneration . J Neurol . 2003;250:287–292
  19. Vaughn JE , Hinds PL , Skoff RP . Electron microscopic studies of Wallerian degeneration in rat optic nerves (I. The multipotential glia) . J Comp Neurol . 1970;140:175–206
  20. Cook RD , Wiśniewski HM . The role of oligodendroglia and astroglia in Wallerian degeneration of the optic nerve . Brain Res . 1973;61:191–206

 Supplemental Material available at AJO.com.Supported by Ministry of Education, Culture, Sports, Science, and Technology (Japan).

PII: S0002-9394(06)00686-6

doi: 10.1016/j.ajo.2006.05.042

American Journal of Ophthalmology
Volume 142, Issue 4 , Pages 591.e1-591.e10 , October 2006

Article Tools

* Image Usage & Resolution