American Journal of Ophthalmology
Volume 142, Issue 4 , Pages 568.e1-568.e6 , October 2006

Topical Interferon Alfa-2b for the Treatment of Recalcitrant Ocular Surface Squamous Neoplasia

  • David J. Holcombe, BSc

      Affiliations

    • University of Queensland, Brisbane, Queensland, Australia
    • ,
  • Graham A. Lee, MD, FRANZCO

      Affiliations

    • University of Queensland, Brisbane, Queensland, Australia
    • Royal Brisbane Hospital, Brisbane, Queensland, Australia.
    • Corresponding Author InformationInquiries to Graham A. Lee, MD, FRANZCO, City Eye Centre, 135 Wickham Tce, Brisbane Q 4000, Australia

,Accepted 22 May 2006.

References 

  1. Maskin SL . Regression of limbal epithelial dysplasia with topical interferon . Arch Ophthalmol . 1994;112:1145–1146
  2. Schechter BA . Conjunctival intraepithelial neoplasia . Ophthalmology . 1999;106:1642–1643
  3. Karp CL , Moore JK , Rosa RH . Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b . Ophthalmology . 2001;108:1093–1098
  4. Schechter BA , Schrier A , Nagler RS , Smith EF , Velasquez GE . Regression of presumed primary conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b . Cornea . 2002;21:6–11
  5. Schechter BA , Nagler RS . Successful treatment with 5-FU . Ophthalmology . 2003;110:1262–1263
  6. Vann RR , Karp CL . Perilesional and topical interferon alfa-2b for conjunctival and corneal neoplasia . Ophthalmology . 1999;106:91–97
  7. Hu FR , Wu MJ , Kuo SH . Interferon treatment for corneolimbal squamous dysplasia . Am J Ophthalmol . 1998;125:118–119
  8. Kobayashi A , Yoshita T , Uchiyama K , et al.   Successful management of conjunctival intraepithelial neoplasia by interferon alpha-2b . Jpn J Ophthalmol . 2002;46:215–217
  9. Boehm MD , Huang AJ . Treatment of recurrent corneal and conjunctival intraepithelial neoplasia with topical interferon alfa 2b . Ophthalmology . 2004;111:1755–1761
  10. Yeatts RP , Engelbrecht NE , Curry CD , Ford JG , Walter KA . 5-Fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea . Ophthalmology . 2000;107:2190–2195
  11. Wilson MW , Hungerford JL , George SM , Madreperla SA . Topical mitomycin C for the treatment of conjunctival and corneal epithelial dysplasia and neoplasia . Am J Ophthalmol . 1997;124:303–311
  12. Frucht-Pery J , Rozenman Y . Mitomycin C therapy for corneal intraepithelial neoplasia . Am J Ophthalmol . 1994;117:164–168
  13. Johnson JA , Gangemi JD . Alpha interferon augments cidofovir’s antiviral and antiproliferative activities . Antimicrob Agents Chemother . 2003;47:2022–2026
  14. Sherman MD , Feldman KA , Farahmand SM , Margolis TP . Treatment of conjunctival squamous cell carcinoma with topical cidofovir . Am J Ophthalmol . 2002;134:432–433

 Supplemental Material available at AJO.com.

PII: S0002-9394(06)00707-0

doi: 10.1016/j.ajo.2006.05.058

American Journal of Ophthalmology
Volume 142, Issue 4 , Pages 568.e1-568.e6 , October 2006

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