American Journal of Ophthalmology
Volume 142, Issue 5 , Pages 771-776.e2 , November 2006

Idiopathic Macular Hole Surgery With Low-Concentration Infracyanine Green-Assisted Peeling of the Internal Limiting Membrane

  • Paolo Lanzetta, MD

      Affiliations

    • Department of Ophthalmology, University of Udine, Udine, Italy
    • Corresponding Author InformationInquiries to Paolo Lanzetta, MD, University of Udine, Department of Ophthalmology, Piazzale S. Maria della Misericordia, 33100 Udine, Italy
    • ,
  • Antonio Polito, MD

      Affiliations

    • Department of Ophthalmology, University of Udine, Udine, Italy
    • ,
  • Michele Del Borrello, MD

      Affiliations

    • Department of Ophthalmology, University of Udine, Udine, Italy
    • ,
  • Raja Narayanan, MD

      Affiliations

    • L. V. Prasad Eye Institute, Hyderabad, India
    • ,
  • Vinay A. Shah, MD

      Affiliations

    • Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
    • ,
  • Antonio Frattolillo, MD

      Affiliations

    • Department of Ophthalmology, University of Udine, Udine, Italy
    • ,
  • Francesco Bandello, MD

      Affiliations

    • Department of Ophthalmology, University of Udine, Udine, Italy

,Accepted 6 June 2006.

References 

  1. Fine B. Limiting membranes of the sensory retina and pigment epithelium (An electron microscopic study). Arch Ophthalmol. 1961;66:847–860
  2. Smiddy WE, Michels RG, de Bustros S, de la Cruz Z, Green WR. Histopathology of tissue removed during vitrectomy for impending idiopathic macular holes. Am J Ophthalmol. 1989;108:360–364
  3. Smiddy WE, Michels RG, Green WR. Morphology, pathology, and surgery of idiopathic vitreoretinal macular disorders (A review). Retina. 1990;10:288–296
  4. Guyer DR, Green WR, de Bustros S, Fine SL. Histopathologic features of idiopathic macular holes and cysts. Ophthalmology. 1990;97:1045–1051
  5. Yooh HS, Brooks HL, Capone A, L’Hernault NL, Grossniklaus HE. Ultrastructural features of tissue removed during idiopathic macular hole surgery. Am J Ophthalmol. 1996;122:67–75
  6. Park DW, Sipperley JO, Sneed SR, Dugel PU, Jacobsen J. Macular hole surgery with internal-limiting membrane peeling and intravitreous air. Ophthalmology. 1999;106:1392–1398
  7. Brooks HL. Macular hole surgery with and without internal limiting membrane peeling. Ophthalmology. 2000;107:1939–1349
  8. Mester V, Kuhn F. Internal limiting membrane removal in the management of full-thickness macular holes. Am J Ophthalmol. 2000;129:769–777
  9. Smiddy WE, Feuer W, Cordahi G. Internal limiting membrane peeling in macular hole surgery. Ophthalmology. 2001;108:1471–1478
  10. Uemoto R, Yamamoto S, Aoki T, Tsukahara I, Yamamoto T, Takeuchi S. Macular configuration determined by optical coherence tomography after idiopathic macular hole surgery with or without internal limiting membrane peeling. Br J Ophthalmol. 2002;86:1240–1242
  11. Ullern M, Roman S, Dhalluin JF, et al. Contribution of intravitreal infracyanine green to macular hole and epimacular membrane surgery—preliminary study. J Fr Ophtalmol. 2002;25:915–920
  12. Da Mata AP, Burk SE, Riemann CD, et al. Indocyanine green-assisted peeling of the retinal internal limiting membrane during vitrectomy surgery for macular hole repair. Ophthalmology. 2001;108:1187–1192
  13. Gandorfer A, Messmer EM, Ulbig MW, Kampik A. Indocyanine green selectively stains the internal limiting membrane. Am J Ophthalmol. 2001;131:387–388
  14. Burk SE, Da Mata AP, Snyder ME, Rosa RH, Foster RE. Indocyanine green-assisted peeling of the retinal internal limiting membrane. Ophthalmology. 2000;107:2010–2014
  15. Kwok AK, Lai TY, Man-Chan W, Woo DC. Indocyanine green assisted retinal internal limiting membrane removal in stage 3 or 4 macular hole surgery. Br J Ophthalmol. 2003;87:71–74
  16. Kwok AK, Lai TY, Yew DT, Li WW. Internal limiting membrane staining with various concentrations of indocyanine green dye under air in macular surgeries. Am J Ophthalmol. 2003;136:223–230
  17. Wolf S, Reichel MB, Wiedemann P, Schnurrbusch UE. Clinical findings in macular hole surgery with indocyanine green-assisted peeling of the internal limiting membrane. Graefes Arch Clin Exp Ophthalmol. 2003;241:589–592
  18. Lee KL, Dean S, Guest S. A comparison of outcomes after indocyanine green and trypan blue assisted internal limiting membrane peeling during macular hole surgery. Br J Ophthalmol. 2005;89:420–424
  19. Perrier M, Sebag M. Trypan blue-assisted peeling of the internal limiting membrane during macular hole surgery. Am J Ophthalmol. 2003;135:903–905
  20. Teba FA, Mohr A, Eckardt C, et al. Trypan blue staining in vitreoretinal surgery. Ophthalmology. 2003;110:2409–2412
  21. Feron EJ, Veckeneer M, Parys-van Ginderdeuren R, van Lommel A, Melles GR, Stalmans P. Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy. Arch Ophthalmol. 2002;120:141–144
  22. Li K, Wong D, Hiscott P, Stanga P, Groenewald C, McGalliard J. Trypan blue staining of internal limiting membrane and epiretinal membrane during vitrectomy: visual results and histopathological findings. Br J Ophthalmol. 2003;87:216–219
  23. Haritoglou C, Eibl K, Schaumberger M, et al. Functional outcome after trypan blue-assisted vitrectomy for macular pucker: a prospective, randomized, comparative trial. Am J Ophthalmol. 2004;138:1–5
  24. Enaida H, Sakamoto T, Hisatomi T, Goto Y, Ishibashi T. Morphological and functional damage of the retina caused by intravitreous indocyanine green in rat eyes. Graefes Arch Clin Exp Ophthalmol. 2002;240:209–213
  25. Gass CA, Haritoglou C, Schaumberger M, Kampik A. Functional outcome of macular hole surgery with and without indocyanine green-assisted peeling of the internal limiting membrane. Graefes Arch Clin Exp Ophthalmol. 2003;241:716–720
  26. Hirata A, Inomata Y, Kawaji T, Tanihara H. Persistent subretinal indocyanine green induces retinal pigment epithelium atrophy. Am J Ophthalmol. 2003;136:353–355
  27. Tadayoni R, Paques M, Girmens JF, Massin P, Gaudric A. Persistence of fundus fluorescence after use of indocyanine green for macular surgery. Ophthalmology. 2003;110:604–608
  28. Gandorfer A, Haritoglou C, Gandorfer A, Kampik A. Retinal damage from indocyanine green in experimental macular surgery. Invest Ophthalmol Vis Sci. 2003;44:316–323
  29. Sippy BD, Engelbrecht NE, Hubbard GB, et al. Indocyanine green effect on cultured human retinal pigment epithelial cells: implication for macular hole surgery. Am J Ophthalmol. 2001;132:433–435
  30. Ciardella AP, Schiff W, Barile G, et al. Persistent indocyanine green fluorescence after vitrectomy for macular hole. Am J Ophthalmol. 2003;136:174–177
  31. Ashikari M, Ozeki H, Tomida K, Sakurai E, Tamai K, Ogura Y. Retention of dye after indocyanine green-assisted internal limiting membrane peeling. Am J Ophthalmol. 2003;136:172–174
  32. Maia M, Kellner L, de Juan E, et al. Effects of indocyanine green injection on the retinal surface and into the subretinal space in rabbits. Retina. 2004;24:80–91
  33. Tokuda K, Tsukamoto T, Fujisawa S, Matsubara M. Evaluation of toxicity due to vital stains in isolated rat retinas. Acta Ophthalmol Scand. 2004;82:189–194
  34. Iriyama A, Uchida S, Yanagi Y, et al. Effects of indocyanine green on retinal ganglion cells. Invest Ophthalmol Vis Sci. 2004;45:943–947
  35. Narayanan R, Kenney MC, Kamjoo S, Trinh TH, Seigel GM, Kuppermann BD. Trypan blue: effect on retinal pigment epithelial and neurosensory retinal cells. Invest Ophthalmol Vis Sci. 2005;46:304–309
  36. Veckeneer M, van Overdam K, Monzer J, et al. Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes. Graefes Arch Clin Exp Ophthalmol. 2001;239:698–704
  37. Stalmans P, van Aken EH, Veckeneer M, Feron EJ, Stalmans I. Toxic effect of indocyanine green on retinal pigment epithelium related to osmotic effects of the solvent. Am J Ophthalmol. 2002;134:282–285
  38. Gandorfer A, Haritoglou C, Gass CA, Ulbig MW, Kampik A. Indocyanine green-assisted peeling of the internal limiting membrane may cause retinal damage. Am J Ophthalmol. 2001;132:431–433
  39. Haritoglou C, Gandorfer A, Gass CA, Schaumberger M, Ulbig MW, Kampik A. Indocyanine green-assisted peeling of the internal limiting membrane in macular hole surgery affects visual outcome—a clinicopathologic correlation. Am J Ophthalmol. 2002;134:836–841
  40. Smiddy WE, Flynn HW. Pathogenesis of macular holes and therapeutic implications. Am J Ophthalmol. 2004;137:525–537
  41. Haritoglou C, Gandorfer A, Schaumberger M, Gandorfer A, Kampik A. Light absorbing properties and osmolarity of indocyanine green depending on concentration and solvent medium. Invest Ophthalmol Vis Sci. 2003;44:2722–2729
  42. Haritoglou C, Gandorfer A, Gass CA, Kampik A. Histology of the vitreoretinal interface after staining of the internal limiting membrane using glucose 5% diluted indocyanine and infracyanine green. Am J Ophthalmol. 2004;137:345–348
  43. Jackson TL, Vote B, Knight BC, El-Amir A, Stanford MR, Marshall J. Safety testing of infracyanine green using retinal pigment epithelium and glial cell cultures. Invest Ophthalmol Vis Sci. 2004;45:3697–3703
  44. van De Moere A, Stalmans P. Anatomical and visual outcome of macular hole surgery with infracyanine green-assisted peeling of the internal limiting membrane, endodrainage, and silicone oil tamponade. Am J Ophthalmol. 2003;136:879–887
  45. Rivett K, Kruger L, Radloff S. Infracyanine-assisted internal limiting membrane peeling in macular hole repair: does it make a difference?. Graefes Arch Clin Exp Ophthalmol. 2004;242:393–396
  46. Kelly NE, Wendel RT. Vitreous surgery for idiopathic macular holes (Results of a pilot study). Arch Ophthalmol. 1991;109:654–659
  47. Wendel RT, Patel AC, Kelly NE, et al. Vitreous surgery for macular holes. Ophthalmology. 1993;100:1671–1676
  48. Poliner LS, Tornambe PE. Retinal pigment epitheliopathy after macular hole surgery. Ophthalmology. 1992;99:1671–1677
  49. Yonemura N, Hirata A, Hasumura T, Negi A. Fundus changes corresponding to visual field defects after vitrectomy for macular hole. Ophthalmology. 2001;108:1638–1643
  50. Banker AS, Freeman WR, Kim JW, et al. Vitrectomy for Macular Hole Study Group (Vision-threatening complications of surgery for full-thickness macular holes). Ophthalmology. 1997;104:1442–1453
  51. Park SS, Marcus DM, Duker JS, et al. Posterior segment complications after vitrectomy for macular hole. Ophthalmology. 1995;102:775–781
  52. Pertile G, Claes C. Silicone oil vs gas for the treatment of full-thickness macular hole. Bull Soc Belge Ophtalmol. 1999;274:31–36
  53. Haritoglou C, Gass CA, Schaumberger M, et al. Macular changes after peeling of the internal limiting membrane in macular hole surgery. Am J Ophthalmol. 2001;132:363–368

PII: S0002-9394(06)00727-6

doi: 10.1016/j.ajo.2006.06.032

American Journal of Ophthalmology
Volume 142, Issue 5 , Pages 771-776.e2 , November 2006

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