American Journal of Ophthalmology
Volume 142, Issue 6 , Pages 945-952.e1 , December 2006

Ultra-high Resolution Optical Coherence Tomography Assessment of Photoreceptors in Retinitis Pigmentosa and Related Diseases

  • Andre J. Witkin, MD

      Affiliations

    • New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts
    • ,
  • Tony H. Ko, PhD

      Affiliations

    • Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
    • ,
  • James G. Fujimoto, PhD

      Affiliations

    • Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
    • ,
  • Annie Chan, MD

      Affiliations

    • New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts
    • ,
  • Wolfgang Drexler, PhD

      Affiliations

    • Institute of Medical Physics, University of Vienna, Vienna, Austria
    • ,
  • Joel S. Schuman, MD

      Affiliations

    • UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    • ,
  • Elias Reichel, MD

      Affiliations

    • New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts
    • ,
  • Jay S. Duker, MD

      Affiliations

    • New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts
    • Corresponding Author InformationInquiries to Jay S. Duker, MD, Ophthalmology Department, Tufts-New England Medical Center, 750 Washington St., Boston, MA, 02111

,Accepted 21 July 2006.

References 

  1. Berson EL. Retinitis pigmentosa (The Friedenwald Lecture). Invest Ophthalmol Vis Sci. 1993;34:1659–1676
  2. Pagon RA. Retinitis pigmentosa. Surv Ophthalmol. 1988;33:137–177
  3. van Soest S, Westerveld A, de Jong PT, et al. Retinitis pigmentosa: defined from a molecular point of view. Surv Ophthalmol. 1999;43:321–334
  4. Milam AH, Li ZY, Fariss RN. Histopathology of the human retina in retinitis pigmentosa. Prog Retin Eye Res. 1998;17:175–205
  5. Milam AH, Li ZY, Cideciyan AV, Jacobson SG. Clinicopathologic effects of the Q64ter rhodopsin mutation in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1996;37:753–765
  6. Tucker GS, Jacobson SG. Morphological findings in retinitis pigmentosa with early diffuse rod dysfunction. Retina. 1988;8:30–41
  7. Stone JL, Barlow WE, Humayun MS, et al. Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch Ophthalmol. 1992;110:1634–1639
  8. Li ZY, Possin DE, Milam AH. Histopathology of bone spicule pigmentation in retinitis pigmentosa. Ophthalmology. 1995;102:805–816
  9. Rodrigues MM, Wiggert B, Hackett J, et al. Dominantly inherited retinitis pigmentosa (Ultrastructure and biochemical analysis). Ophthalmology. 1985;92:1165–1172
  10. Hee MR, Izatt JA, Swanson EA, et al. Optical coherence tomography of the human retina. Arch Ophthalmol. 1995;113:325–332
  11. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254:1178–1181
  12. Puliafito CA, Hee MR, Lin CP, et al. Imaging of macular diseases with optical coherence tomography. Ophthalmology. 1995;102:217–229
  13. Hee MR, Puliafito CA, Wong C, et al. Optical coherence tomography of macular holes. Ophthalmology. 1995;102:748–756
  14. Hee MR, Puliafito CA, Wong C, et al. Optical coherence tomography of central serous chorioretinopathy. Am J Ophthalmol. 1995;120:65–74
  15. Hee MR, Puliafito CA, Wong C, et al. Quantitative assessment of macular edema with optical coherence tomography. Arch Ophthalmol. 1995;113:1019–1029
  16. Hee MR, Baumal CR, Puliafito CA, et al. Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. Ophthalmology. 1996;103:1260–1270
  17. Apushkin MA, Fishman GA, Janowicz MJ. Monitoring cystoid macular edema by optical coherence tomography in patients with retinitis pigmentosa. Ophthalmology. 2004;111:1899–1904
  18. Chauhan DS, Marshall J. The interpretation of optical coherence tomography images of the retina. Invest Ophthalmol Vis Sci. 1999;40:2332–2342
  19. Hirakawa H, Iijima H, Gohdo T, Tsukahara S. Optical coherence tomography of cystoid macular edema associated with retinitis pigmentosa. Am J Ophthalmol. 1999;128:185–191
  20. Sallum JM, Farah ME, Saraiva VS. Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide: case report. Adv Exp Med Biol. 2003;533:79–81
  21. Ko TH, Fujimoto JG, Duker JS, et al. Comparison of ultra-high and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. Ophthalmology. 2004;111:2033–2043
  22. Drexler W, Morgner U, Ghanta RK, et al. Ultra-high resolution ophthalmic optical coherence tomography. Nat Med. 2001;7:502–507
  23. Drexler W, Sattmann H, Hermann B, et al. Enhanced visualization of macular pathology with the use of ultra-high resolution optical coherence tomography. Arch Ophthalmol. 2003;121:695–706
  24. Ergun E, Hermann B, Wirtitsch M, et al. Assessment of central visual function in Stargardt disease/fundus flavimaculatus with ultra-high resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2005;46:310–316
  25. Unterhuber A, Povazay B, Hermann B, et al. Compact, low-cost Ti:Al2O3 laser for in vivo ultra-high resolution optical coherence tomography. Opt Lett. 2003;28:905–907
  26. American National Standards Institute. Safe use of lasers. New York: American National Standards Institute; 1993;
  27. American National Standards Institute. Safe use of lasers, ANSI Z 1361. New York: American National Standards Institute; 1993;
  28. Swanson EA, Izatt JA, Hee MR. In vivo retinal imaging by optical coherence tomography. Opt Lett. 1993;18:1864–1866
  29. Heckenlively JR. Retinitis pigmentosa. Philadelphia, Pennsylvania: J.B. Lippincott Co; 1988;
  30. Anger EM, Unterhuber A, Hermann B, et al. Ultrahigh resolution optical coherence tomography of the monkey fovea (Identification of retinal sublayers by correlation with semithin histology sections). Exp Eye Res. 2004;78:1117–1125
  31. Kondo M, Ito Y, Ueno S, et al. Foveal thickness in occult macular dystrophy. Am J Ophthalmol. 2003;135:725–728
  32. Zambarakji HJ, Schlottmann P, Tanner V, et al. Macular microholes: pathogenesis and natural history. Br J Ophthalmol. 2005;89:189–193
  33. Piccolino FC, de la Longrais RR, Ravera G, et al. The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy. Am J Ophthalmol. 2005;139:87–99
  34. Jorge R, Costa RA, Quirino LS, et al. Optical coherence tomography findings in patients with late solar retinopathy. Am J Ophthalmol. 2004;137:1139–1143
  35. Moshfeghi AA, Flynn HW, Elner SG, et al. Persistent outer retinal defect after successful macular hole repair. Am J Ophthalmol. 2005;139:183–184
  36. Kitaya N, Hikichi T, Kagokawa H, et al. Irregularity of photoreceptor layer after successful macular hole surgery prevents visual acuity improvement. Am J Ophthalmol. 2004;138:308–310
  37. Steinkamp PN, Watzke RC, Solomon JD. An unusual case of solar retinopathy. Arch Ophthalmol. 2003;121:1798–1799
  38. Villate N, Lee JE, Venkatraman A, Smiddy WE. Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes. Am J Ophthalmol. 2005;139:280–289
  39. Nassif N, Cense B, Park BH, et al. In vivo human retinal imaging by ultra-high speed spectral domain optical coherence tomography. Opt Lett. 2004;29:480–482
  40. Wojtkowski M, Bajraszewski T, Gorczynska I, et al. Ophthalmic imaging by spectral optical coherence tomography. Am J Ophthalmol. 2004;138:412–419

PII: S0002-9394(06)00864-6

doi: 10.1016/j.ajo.2006.07.024

American Journal of Ophthalmology
Volume 142, Issue 6 , Pages 945-952.e1 , December 2006

Article Tools

* Image Usage & Resolution