Functional Visual Acuity in Stevens-Johnson Syndrome

Kaido, Minako; Dogru, Murat; Yamada, Masakazu; Sotozono, Chie; Kinoshita, Shigeru; Shimazaki, Jun; Tsubota, Kazuo

doi:10.1016/j.ajo.2006.07.055

« Previous Next »American Journal of Ophthalmology
Volume 142, Issue 6 , Pages 917-922.e1, December 2006

Functional Visual Acuity in Stevens-Johnson Syndrome

Minako Kaido, MD
- Department of Ophthalmology, Keio University School of Medicine, Tokyo
- Inquiries to Minako Kaido, MD, Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 25, Shinjuku-ku, Tokyo, Japan
Murat Dogru, MD
- Department of Ophthalmology, Keio University School of Medicine, Tokyo
- Department of Ophthalmology, Tokyo Dental College, Ichikawa
- J&J Ocular Surface and Visual Optics Department, Keio University School of Medicine, Tokyo, Japan.
Masakazu Yamada, MD
- Department of Ophthalmology, Tokyo Medical Center, Tokyo
Chie Sotozono, MD
- Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto
Shigeru Kinoshita, MD
- Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto
Jun Shimazaki, MD
- Department of Ophthalmology, Tokyo Dental College, Ichikawa
Kazuo Tsubota, MD
- Department of Ophthalmology, Keio University School of Medicine, Tokyo

Accepted 27 July 2006. published online 01 September 2006.

Purpose

To evaluate the correlation of functional visual acuity (FVA) measurement with ocular surface findings in patients with Stevens-Johnson syndrome (SJS).

Design

Prospective comparative study.

Methods

Sixty-nine eyes of 38 patients with chronic SJS assessed at the Tokyo Dental College, Tokyo Medical Center, and the Kyoto Prefectural University of Medicine, Department of Ophthalmology, Kyoto, Japan, were studied. Twenty eyes of 10 normal subjects and 40 eyes of 20 patients with Sjögren syndrome (SS) were also studied. Conventional Landolt visual acuity (VA) and FVA examinations and slit-lamp examinations were performed. FVA was measured continuously by the FVA measurement system during a 30-second blink-free period in one eye. The visual maintenance ratio (VMR) was calculated as follows: VMR = [(2.7 − FVA)/(2.7 − baseline VA)], where logarithm of minimal angle of resolution values of FVA were entered into the formula and 2.7 represented the lowest visual acuity in this series. Slit-lamp examinations, Schirmer test, and fluorescein vital stainings were also performed in all subjects.

Results

VMR was markedly lower in patients with SJS compared with patients with SS and controls. FVA values showed a relation with the presence of corneal opacity and vascularization.

Conclusions

The FVA measurement system is not only a useful tool in the evaluation of dynamic VA changes, but also reflects the ocular surface clinical findings in SJS.