American Journal of Ophthalmology
Volume 143, Issue 4 , Pages 623-628.e1 , April 2007

Epithelial Herpetic Simplex Keratitis Recurrence and Graft Survival After Corneal Transplantation in Patients With and Without Atopy

  • Renata A. Rezende

      Affiliations

    • Department of Ophthalmology, Federal University of Sao Paulo (UNIFESP)–R. Botucatu, Spain, Brazil
    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • Corresponding Author InformationInquiries to Renata A. Rezende, Rua Visconde de Silva, 321/201 – Humaita, Rio de Janeiro–RJ, Brazil
    • ,
  • Tiago Bisol

      Affiliations

    • Central Hospital of Brazilian Air-Force (HCA)–Rua Barão de Itapagipe, Rio de Janeiro, Brazil.
    • ,
  • Kristin Hammersmith

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Ana Luisa Hofling-Lima

      Affiliations

    • Department of Ophthalmology, Federal University of Sao Paulo (UNIFESP)–R. Botucatu, Spain, Brazil
    • ,
  • Guy F. Webster

      Affiliations

    • Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
    • ,
  • Juliana F. Freitas

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Christopher J. Rapuano

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Peter R. Laibson

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania
    • ,
  • Elisabeth J. Cohen

      Affiliations

    • Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania

,Accepted 4 December 2006.

References 

  1. Liesegang TJ. Epidemiology of ocular herpes simplex (Natural history in Rochester, Minnesota, 1950 through 1982). Arch Ophthalmol. 1989;107:1160–1165
  2. Easty D, Entwistle C, Funk A, Witcher J. Herpes simplex keratitis and keratoconus in the atopic patient: A clinical and immunological study. Trans Ophthalmol Soc UK. 1975;95:267–276
  3. Garrity JA, Liesegang TJ. Ocular complications of atopic dermatitis. Can J Ophthalmol. 1984;19:21–24
  4. Wilhelmus KR, Falcon MG, Jones BR. Bilateral herpetic keratitis. Br J Ophthalmol. 1981;65:385–387
  5. Margolis TP, Ostler HB. Treatment of ocular disease in eczema herpeticum. Am J Ophthalmol. 1990;110:274–279
  6. Cosar B, Sridahr MS, Cohen EJ, et al. Indications for penetrating keratoplasty and associated procedures, 1996 to 2000. Cornea. 2002;21:234–236
  7. Foster CS, Duncan J. Penetrating keratoplasty for herpes simplex keratitis. Am J Ophthalmol. 1981;92:336–343
  8. Moyes AL, Sugar A, Munsh DC, Barnes RD. Antiviral therapy after penetrating keratoplasty for herpes simplex keratitis. Arch Ophthalmol. 1994;112:601–607
  9. Sterk CC, Jager MJ, Berg MS. Recurrent herpetic keratitis in penetrating keratoplasty. Doc Ophthalmol. 1995;90:29–33
  10. Cohen EJ, Laibson PR, Arentsen JJ. Corneal transplantation for herpes simplex keratitis. Am J Ophthalmol. 1983;95:645–650
  11. Langston RH, Pavan-Langston D, Dohlman CH. Antiviral medication and corneal wound healing. Arch Ophthalmol. 1974;92:509–513
  12. Rezende RA, Hammersmith K, Bisol T, et al. Comparative study of ocular herpes simplex virus in patients with and without self-reported atopy. Am J Ophthalmol. 2006;141:1120–1125
  13. Rezende RA, Bisol T, Hammersmith K, et al. Efficacy of oral antiviral prophylaxis in preventing ocular herpes simplex virus recurrences in patients with and without self-reported atopy. Am J Ophthalmol. 2006;142:563–567
  14. Holland E, Schwartz G. Classification of herpes simplex virus keratitis. Cornea. 1999;18:144–154
  15. Asher MI, Keil U, Anderson HR, et al. The International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483–491
  16. Biino G, Rezzani C, Grassi M, Marinoni A. ECRHS screening questionnaire scoring: a methodological suggestion for asthma assessment: European Community Health Survey. J Outcome Meas 2000–2001;4;740–762.
  17. Beyer CF, Hill JM, Reidy JJ, Beuerman RW. Corneal nerve disruption reactivates virus in rabbits latently infected with HSV-1. Invest Ophthalmol Vis Sci. 1990;31:925–932
  18. Beyer CF, Arens MQ, Hill GA, et al. Oral acyclovir reduces the incidence of recurrent herpes simplex keratitis in rabbits after penetrating keratoplasty. Arch Ophthalmol. 1989;107:1200–1205
  19. Haruta Y, Maguire LJ, Rootman DS, Hill JM. Recurrent herpes simplex virus type 1 corneal epithelial lesions after radial keratotomy in the rabbit. Arch Ophthalmol. 1987;105:692–694
  20. Beyer CF, Arens MQ, Hill JM, et al. Penetrating keratoplasty in rabbits induces latent HSV-1 reactivation when corticosteroids are used. Curr Eye Res. 1989;8:1323–1329
  21. Rezende RA, Uchoa UB, Raber IM, et al. New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty. Am J Ophthalmol. 2004;137:415–419
  22. Portnoy SL, Beyer CF, Hill JM, Kaufman HE. The coincidence of HSV-1 ocular cultures with HSV-1 corneal epithelial defect in rabbits after experimental penetrating keratoplasty. Cornea. 1991;10:17–20
  23. Remeijer L, Doornenbal P, Geerards AJM, et al. Newly acquired herpes virus keratitis after penetrating keratoplasty. Ophthalmology. 1997;104:648–652
  24. Liesegang T. Ocular herpes simplex infection: pathogenesis and current therapy. Mayo Clin Proc. 1988;63:1092–1096
  25. Pavan-Langston D, Rong BL, Dunkel EC. Extraneuronal herpetic latency: animal and human corneal studies. Acta Ophthalmol Suppl. 1989;192:135–141
  26. Rong BL, Pavan-Langston D, Weng QP, et al. Detection of herpes simplex virus, thymine kinase, and latency-associated transcript gene sequences in human herpetic corneas by polymerase chain reaction. Invest Ophthalmol Vis Sci. 1991;32:1808–1815
  27. Haruta Y, Rootman DS, Xie L, et al. Recurrent HSV-1 corneal lesions in rabbits induced by cyclophosphamide and dexamethasone. Invest Ophthalmol Vis Sci. 1989;30:371–376
  28. Brandt BM, Mandleblatt J, Asbell PA. Risk factors for herpes simplex-induced keratitis: A case control study. Ann Ophthalmol. 1994;26:12–16
  29. Laibson PR, Kibrick S. Recurrence of herpes simplex virus in rabbit eyes: results of a three-year study. Invest Ophthalmol. 1969;8:346–350
  30. Cook SD. Herpes simplex infection in the eye. Br J Ophthalmol. 1992;76:365–366

PII: S0002-9394(06)01411-5

doi: 10.1016/j.ajo.2006.12.003

American Journal of Ophthalmology
Volume 143, Issue 4 , Pages 623-628.e1 , April 2007

Article Tools

* Image Usage & Resolution