American Journal of Ophthalmology
Volume 143, Issue 4 , Pages 629-634 , April 2007

Methicillin-Resistant Staphylococcus aureus Infectious Keratitis Following Refractive Surgery

  • Renée Solomon

      Affiliations

    • Ophthalmic Consultants of Long Island, Rockville Centre, New York
  • ,
  • Eric D. Donnenfeld

      Affiliations

    • Ophthalmic Consultants of Long Island, Rockville Centre, New York
    • Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, New York
    • Corresponding Author InformationInquiries to Eric D. Donnenfeld, Ophthalmic Consultants of Long Island, Ryan Medical Arts Building, Suite 402, 2000 North Village Avenue, Rockville Centre, New York 11570
  • ,
  • Henry D. Perry

      Affiliations

    • Ophthalmic Consultants of Long Island, Rockville Centre, New York
  • ,
  • Roy S. Rubinfeld

      Affiliations

    • Washington Eye Physicians and Surgeons, Chevy Chase, Maryland; and Georgetown University Medical Center, and the Washington Hospital Center, Washington, DC
  • ,
  • Michael Ehrenhaus

      Affiliations

    • Saint Vincent Catholic Medical Center of Brooklyn and Queens, St Joseph’s Hospital, Flushing, New York
  • ,
  • John R. Wittpenn Jr

      Affiliations

    • Ophthalmic Consultants of Long Island, Rockville Centre, New York
    • Department of Ophthalmology, State University of New York at Stony Brook, Stony Brook, New York
  • ,
  • Kerry D. Solomon

      Affiliations

    • Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina
  • ,
  • Edward E. Manche

      Affiliations

    • Department of Ophthalmology, Stanford University School of Medicine, Stanford, California
  • ,
  • Majid Moshirfar

      Affiliations

    • Moran Eye Center, University of Utah, Salt Lake City, Utah
  • ,
  • Dennis C. Matzkin

      Affiliations

    • EyeSight Laser Center, Atlanta, Georgia
  • ,
  • Reza M. Mozayeni

      Affiliations

    • Providence Eye and Laser Specialists, Charlotte, North Carolina
  • ,
  • Robert K. Maloney

      Affiliations

    • Maloney Vision Institute, Los Angeles, California.

,Accepted 17 December 2006.

References 

  1. Solomon KD, Holzer MP, Sandoval HP, et al. Refractive Surgery Survey 2001. J Cataract Refract Surg. 2002;28:346–355
  2. Stulting RD, Carr JD, Thompson KP, et al. Complications of laser in situ keratomileusis for the correction of myopia. Ophthalmology. 1999;106:13–20
  3. Solomon R, Donnenfeld ED, Azar DT, et al. Infectious keratitis after laser in situ keratomileusis: results of an ASCRS Survey. J Cataract Refract Surg. 2003;29:2001–2006
  4. Donnenfeld ED, O’Brien TP, Solomon R, Perry HD, Speaker MG, Wittpenn J. Infectious keratitis after photorefractive keratectomy. Ophthalmology. 2003;110:743–747
  5. Garg P, Bansal AK, Sharma S, Vemuganti GK. Bilateral infectious keratitis after laser in situ keratomileusis: a case report and review of the literature. Ophthalmology. 2001;108:121–125
  6. Pushker N, Dada T, Sony P, Ray M, Agarwal T, Vajpayee RB. Microbial keratitis after laser in situ keratomileusis. J Refract Surg. 2002;18:280–286
  7. Levartovsky S, Rosenwasser G, Goodman D. Bacterial keratitis after laser in situ keratomileusis. Ophthalmology. 2001;108:321–325
  8. Rubinfeld RS, Negvesky GJ. Methicillin-resistant Staphylococcus aureus ulcerative keratitis after laser in situ keratomileusis. J Cataract Refract Surg. 2001;27:1523–1525
  9. Rudd JC, Moshirfar M. Methicillin-resistant Staphylococcus aureus keratitis after laser in situ keratomileusis. J Cataract Refract Surg. 2001;27:471–473
  10. Webber SK, Lawless MA, Sutton GL, Rogers CM. Staphylococcal infection under a LASIK flap. Cornea. 1999;18:361–365
  11. Karp CL, Tuli SS, Yoo SH, et al. Infectious keratitis after LASIK. Ophthalmology. 2003;110:503–510
  12. Förster W, Becker K, Hungermann D, Busse H. Methicillin-resistant Staphylococcus aureus keratitis after excimer laser photorefractive keratectomy. J Cataract Refract Surg. 2002;28:722–724
  13. Solomon R, Donnenfeld ED, Perry HD, Biser S. Bilateral methicillin-resistant Staphylococcus aureus keratitis in a medical resident following an uneventful bilateral photorefractive keratectomy. Eye Contact Lens. 2003;29:187–189
  14. Goldstein MH, Kowalski RP, Gordon YJ. Emerging fluoroquinolone resistance in bacterial keratitis: a five-year review. Ophthalmology. 1999;106:1313–1318
  15. Marangon FB, Miller D, Muallem MS, Romano AC, Alfonso EC. Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. Am J Ophthalmol. 2004;137:453–458
  16. Warshawsky B, Hussain Z, Gregson DB, et al. Hospital- and community-based surveillance of methicillin-resistant Staphylococcus aureus: previous hospitalization is the major risk factor. Infect Control Hosp Epidemiol. 2000;21:724–727
  17. Chambers HF. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin Microbiol Rev. 1997;10:781–791
  18. Chambers HF. The changing epidemiology of Staphylococcus aureus?. Emerg Infect Dis. 2001;7:178–182
  19. Finland M. Emergence of antibiotic resistance in hospitals, 1935–1975. Rev Infect Dis. 1979;1:4–22
  20. Mather R, Karenchak LM, Romanowski EG, Kowalski RP. Fourth-generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. Am J Ophthalmol. 2002;133:463–466
  21. Aliprandis E, Ciralsky J, Lai H, Herling I, Katz HR. Comparative efficacy of topical moxifloxacin vs ciprofloxacin and vancomycin in the treatment of P. aeruginosa and ciprofloxacin-resistant MRSA keratitis in rabbits. Cornea. 2005;24:201–205
  22. Abudu L, Blair I, Fraise A, Cheng KK. Methicillin-resistant Staphylococcus aureus (MRSA): a community-based prevalence survey. Epidemiol Infect. 2001;126:351–356
  23. Chiang RK, Rapuano CJ. Recurrent methicillin-resistant Staphylococcus aureus wound ulcer after clear-cornea cataract surgery. CLAO J. 2002;28:109–110
  24. Insler MS, Fish LA, Silbernagel J, Hobden JA, O’Callaghan RJ, Hill JM. Successful treatment of methicillin-resistant Staphylococcus aureus keratitis with topical ciprofloxacin. Ophthalmology. 1991;98:1690–1692
  25. Eiferman RA, O’Neill KP, Morrison NA. Methicillin-resistant Staphylococcus aureus corneal ulcers. Ann Ophthalmol. 1991;23:414–415
  26. Nakata K, Inoue Y, Harada J, et al. A high incidence of Staphylococcus aureus colonization in the external eyes of patients with atopic dermatitis. Ophthalmology. 2000;107:2167–2171
  27. Oshima Y, Ohji M, Inoue Y, et al. Methicillin-resistant Staphylococcus aureus infections after scleral buckling procedures for retinal detachments associated with atopic dermatitis. Ophthalmology. 1999;106:142–147
  28. Kojima Y, Majima K, Gotoh M, Kunoh T, Nogawa H. A case of ocular infection due to methicillin-resistant Staphylococcus aureus after surgery for retinal detachment. Atarashii Ganka, Journal of the Eye [Japanese]. 1995;12:653–656
  29. Kato T, Hayasaka S. Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci from conjunctivas of preoperative patients. Jpn J Ophthalmol. 1998;42:461–465
  30. Watanabe K, Numata-Watanabe K, Hayasaka S. Methicillin-resistant Staphylococci and ofloxacin-resistant bacteria from clinically healthy conjunctivas. Ophthalmic Res. 2001;33:136–139
  31. Matthews TD, Frazer DG, Minassian DC, Radford CF, Dart JK. Risks of keratitis and patterns of use with disposable contact lenses. Arch Ophthalmol. 1992;110:1559–1562
  32. Abb J. In vitro activity of linezolid, quinupristin-dalfopristin, vancomycin, teicoplanin, moxifloxacin and mupirocin against methicillin-resistant Staphylococcus aureus: comparative evaluation by the E test and a broth microdilution method. Diagn Microbiol Infect Dis. 2002;43:319–321
  33. Jensen HG, Felix C. In vitro antibiotic susceptibilities of ocular isolates in North and South America (In Vitro Antibiotic Testing Group). Cornea. 1998;17:79–87
  34. Romanowski EG, Mah FS, Yates KA, Kowalski RP, Gordon YJ. The successful treatment of gatifloxacin-resistant Staphylococcus aureus keratitis with Zymar (Gatifloxacin 0.3%) in a NZW rabbit model. Am J Ophthalmol. 2005;139:867–877
  35. Dajcs JJ, Thibodeaux BA, Marquart ME, Girgis DO, Traidej M, O’Callaghan RJ. Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. Antimicrob Agents Chemother. 2004;48:1948–1952
  36. Tungsiripat T, Sarayba MA, Kaufman MB, et al. Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model. Am J Ophthalmol. 2003;136:76–81
  37. Moreau JM, Conerly LL, Hume EB, et al. Effectiveness of mupirocin and polymyxin B in experimental Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens keratitis. Cornea. 2002;21:807–811
  38. Nagano R, Shibata K, Adachi Y, Imamura H, Hashizume T, Morishima H. In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2000;44:489–495
  39. Weigelt J, Kaafarani HM, Itani KM, Swanson RN. Linezolid eradicates MRSA better than vancomycin from surgical-site infections. Am J Surg. 2004;188:760–766

PII: S0002-9394(06)01434-6

doi: 10.1016/j.ajo.2006.12.029

American Journal of Ophthalmology
Volume 143, Issue 4 , Pages 629-634 , April 2007