American Journal of Ophthalmology
Volume 144, Issue 4 , Pages 547-551.e1 , October 2007

Efficacy of Valacyclovir vs Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease: A Pilot Study

  • Elisabetta Miserocchi

      Affiliations

    • Department of Ophthalmology and Visual Sciences, San Raffaele Scientific Institute, Milan, Italy
    • Corresponding Author InformationInquiries to Elisabetta Miserocchi, Department of Ophthalmology and Visual Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    • ,
  • Giulio Modorati

      Affiliations

    • Department of Ophthalmology and Visual Sciences, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Laura Galli

      Affiliations

    • Clinic of Infectious Diseases, Vita-Salute San Raffaele University, Milan, Italy.
    • ,
  • Paolo Rama

      Affiliations

    • Department of Ophthalmology and Visual Sciences, San Raffaele Scientific Institute, Milan, Italy

,Accepted 1 June 2007.

References 

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  2. Liesegang TJ. Herpes simplex virus epidemiology and ocular importance. Cornea. 2001;20:1–13
  3. Labetoulle M, Auquier P, Conrad H, et al. Incidence of herpes simplex keratitis in France. Ophthalmology. 2005;112:888–895
  4. Liesegang TJ. Classification of herpes simplex virus keratitis and anterior uveitis. Cornea. 1999;18:127–143
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  15. Fife KH, Crumpacker CS, Mertz GJ, Hill EL, Boone GS Acyclovir Study Group. Recurrence and resistance patterns of herpes simplex virus following cessation of > or = 6 years of chronic suppression with acyclovir. J Infect Dis. 1994;169:1338–1341
  16. Colin J, Prisant O, Cochener B, Lescale O, Rolland B, Hoang-Xuan T. Comparison of the efficacy and safety of valacyclovir and acyclovir for the treatment of herpes zoster ophthalmicus. Ophthalmology. 2000;107:1507–1511
  17. Baker DA, Blythe JG, Miller JM. Once-daily valacyclovir hydrochloride for suppression of recurrent genital herpes. Obstet Gynecol. 1999;94:103–106
  18. Corey L, Wald A, Patel R, et al. Once daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004;350:11–20
  19. Spruance SL, Tyring SK, DeGregorio B, Miller C, Beutner K Valacyclovir HSV Study Group. A large-scale, placebo-controlled, dose-ranging trial of peroral valacyclovir for episodic treatment of recurrent herpes genitalis. Arch Intern Med. 1996;156:1729–1735
  20. Miserocchi E, Waheed NK, Dios E, et al. Visual outcome in herpes simplex virus and varicella zoster virus uveitis: a clinical evaluation and comparison. Ophthalmology. 2002;109:1532–1537
  21. Rezende RA, Bisol T, Hammersmith K, et al. Efficacy of oral antiviral prophylaxis in preventing ocular herpes simplex virus recurrences in patients with and without self-reported atopy. Am J Ophthalmol. 2006;142:563–567
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PII: S0002-9394(07)00524-7

doi: 10.1016/j.ajo.2007.06.001

American Journal of Ophthalmology
Volume 144, Issue 4 , Pages 547-551.e1 , October 2007

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