American Journal of Ophthalmology
Volume 145, Issue 5 , Pages 834-840.e1 , May 2008

Clinical Features of Cytomegalovirus Anterior Uveitis in Immunocompetent Patients

  • Soon-Phaik Chee

      Affiliations

    • Singapore National Eye Centre, Singapore, Republic of Singapore
    • Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    • Singapore Eye Research Institute, Singapore, Republic of Singapore
    • Corresponding Author InformationInquiries to Soon-Phaik Chee, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Republic of Singapore
    • ,
  • Kristine Bacsal

      Affiliations

    • Singapore National Eye Centre, Singapore, Republic of Singapore
    • ,
  • Aliza Jap

      Affiliations

    • Singapore National Eye Centre, Singapore, Republic of Singapore
    • Division of Ophthalmology, Changi General Hospital, Singapore, Republic of Singapore.
    • ,
  • Su-Yun Se-Thoe

      Affiliations

    • Singapore General Hospital, Singapore, Republic of Singapore
    • ,
  • Ching Li Cheng

      Affiliations

    • Singapore National Eye Centre, Singapore, Republic of Singapore
    • ,
  • Ban Hock Tan

      Affiliations

    • Singapore General Hospital, Singapore, Republic of Singapore

,Accepted 7 December 2007.

References 

  1. Daicker B. Cytomegalovirus panuveitis with infection of corneo-trabecular endothelium in AIDS. Ophthalmologica. 1988;197:169–175
  2. Bale JF, O'Neil ME, Folberg R. Murine cytomegalovirus ocular infection in immunocompetent and cyclophosphamide-treated mice (Potentiation of ocular infection by cyclophosphamide). Invest Ophthalmol Vis Sci. 1991;32:1749–1756
  3. Koizumi N, Suzuki T, Uno T, et al. Cytomegalovirus as an etiologic factor in corneal endotheliitis. Ophthalmology. Forthcoming.
  4. Teoh SB, Thean L, Koay E. Cytomegalovirus in aetiology of Posner-Schlossman syndrome: evidence from quantitative polymerase chain reaction. Eye. 2005;19:1338–1340
  5. Bloch-Michel E, Dussaix E, Cerqueti P, Patarin P. Possible role of cytomegalovirus infection in the etiology of the Posner-Schlossmann syndrome. Int Ophthalmol. 1987;11:95–96
  6. De Schryver I, Rozenberg F, Cassoux N, et al. Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis. Br J Ophthalmol. 2006;90:852–855
  7. Markomichelakis NN, Canakis C, Zafirakis P, Marakis T, Mallias I, Theodossiadis G. Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy. Ophthalmology. 2002;109:879–882
  8. Van Boxtel LA, van der Lelij A, van der Meer J, Los LI. Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients. Ophthalmology. 2007;114:1358–1362
  9. Chee SP, Bascal K, Jap A, Se-Thoe SY, Cheng CL, Tan BH. Corneal endotheliitis associated with evidence of cytomegalovirus infection. Ophthalmology. 2007;114:798–803
  10. Boeckh M, Huang M, Ferrenberg J, et al. Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR. J Clinic Microbiol. 2004;42:1142–1148
  11. Blok MJ, Goossens VJ, Vanherle SJ, et al. Diagnostic value of monitoring human cytomegalovirus late pp67 mRNA expression in renal-allograft recipients by nucleic acid sequence-based amplification. J Clin Microbiol. 1998;36:1341–1346
  12. Dabil H, Boley ML, Schmitz TM, Van Gelder RN. Validation of a diagnostic multiplex polymerase chain reaction assay for infectious posterior uveitis. Arch Ophthalmol. 2001;119:1315–1322
  13. Amano S, Oshika T, Kaji Y, Numaga J, Matsubara M, Ariae M. Herpes simplex virus in the trabeculum of an eye with corneal endotheliitis. Am J Ophthalmol. 1999;127:721–722
  14. Maudgal P, Missoten AL, De Clerq E, Descamps J. Varicella zoster virus in the human corneal endothelium: a case management. Bull Soc Belge Ophthalmol. 1980;190:71–86
  15. Singh K, Sodhi PK. Mumps-induced corneal endotheliitis. Cornea. 2004;23:400–402
  16. Yamamoto S, Pavan-Langston D, Tada R, et al. Possible role of herpes simplex virus in the origin of Posner-Schlossman syndrome. Am J Ophthalmol. 1995;119:796–798
  17. Barequet IS, Li Q, Wang Y, O'Brien TP, Hooks JJ, Stark WJ. Herpes simplex virus DNA identification from aqueous fluid in Fuchs heterochromic iridocyclitis. Am J Ophthalmol. 2000;129:672–673
  18. Quentin CD, Reiber H. Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor. Am J Ophthalmol. 2004;138:46–54
  19. De Groot-Mijnes JDF, de Visser L, Rothova A, Schuller M, van Loon AM, Weersink AJL. Rubella virus is associated with Fuchs heterochromic iridocyclitis. Am J Ophthalmol. 2006;141:212–214
  20. Wong A, Tan KH, Tee CS, Yeo GS. Seroprevalence of cytomegalovirus, toxoplasma and parvovirus in pregnancy. Singapore Med J. 2000;41:151–155
  21. Fox GM, Crouse CA, Chuang EL, et al. Detection of herpes virus DNA in vitreous and aqueous specimens by the polymerase chain reaction. Arch Ophthalmol. 1991;109:266–271
  22. Pendergast SD, Werner J, Drevon A, Wiedbrauk DL. Absence of the herpes virus DNA by polymerase chain reaction in ocular fluids obtained from immunocompetent patients. Retina. 2000;20:389–393
  23. Yamamoto S, Pavan-Langstone D, Kinoshita S, Nishida K, Shimomura Y, Tano Y. Detecting herpes virus DNA in uveitis using the polymerase chain reaction. Br J Ophthalmol. 1996;80:465–468
  24. Mietz H, Aisenbrey S, Bartz-Schmidt KU, Bamborschke S, Krieglstein GK. Ganciclovir for the treatment of anterior uveitis. Graefes Arch Clin Exp Ophthalmol. 2000;238:905–909
  25. Jap A, Sivakumar M, Chee SP. Is Posner-Schlossman syndrome benign?. Ophthalmology. 2001;108:913–918

 See accompanying Editorial on page 769.

PII: S0002-9394(07)01051-3

doi: 10.1016/j.ajo.2007.12.015

American Journal of Ophthalmology
Volume 145, Issue 5 , Pages 834-840.e1 , May 2008

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