American Journal of Ophthalmology
Volume 145, Issue 5 , Pages 879-882 , May 2008

Endophthalmitis Associated with Intravitreal Anti-Vascular Endothelial Growth Factor Therapy Injections in An Office Setting

  • Suman Pilli

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • Department of Ophthalmology, Frimley Park Hospital, Frimley, United Kingdom.
    • ,
  • Athanasios Kotsolis

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • ,
  • Richard F. Spaide

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • Corresponding Author InformationInquiries to Richard F. Spaide, 460 Park Avenue, 5th Floor, New York, NY 10022
    • ,
  • Jason Slakter

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • ,
  • K. Bailey Freund

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • ,
  • John Sorenson

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • ,
  • James Klancnik

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York
    • ,
  • Michael Cooney

      Affiliations

    • Vitreous Retina Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center at Manhattan Eye, Ear, and Throat Hospital, New York, New York

,Accepted 31 December 2007.

References 

  1. Scott IU, Flynn HW. Reducing the risk of endophthalmitis following intravitreal injections. Retina. 2007;27:10–12
  2. Aiello LP, Brucker AJ, Chang S, et al. Evolving guidelines for intravitreous injections. Retina. 2005;25:949–950
  3. Gragoudas ES, Adamis AP, Cunningham ET, et al. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med. 2004;351:2805–2816
  4. Brown DM, Kaiser PK, Michels M, et al. ANCHOR Study Group Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432–1444
  5. Rosenfeld PJ, Brown DM, Heier JS, et al. MARINA Study Group Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419–1431
  6. Speaker MG, Milch FA, Shah MK. Role of external bacterial flora in pathogenesis of of acute postoperative endophthalimitis. Ophthalmology. 1991;98:639–649
  7. King-Smith PE, Fink BA, Hill RM, Koelling KW, Tiffany JM. The thickness of the tear film. Curr Eye Res. 2004;29:357–368
  8. Apt L, Isenberg S, Yoshimori R, Paez J. Chemical preparation of the eye in ophthalmic surgery III: effect of povidone-iodine on the conjunctiva. Arch Ophthalmol. 1984;102:728–729
  9. Pansell T, Porsblad M, Abdi S. The effect of vertical gaze position on ocular tear film stability. Clin Exp Optom. 2007;90:176–181
  10. Grimes S, Mein C, Trevino S. Preoperative antibiotic and povidone-iodine preparation of the eye. Ann Ophthalmol. 1991;23:263–266
  11. Isenberg S, Apt L, Yoshimori R, Khwarg S. Chemical preparation of the eye in ophthalmic surgery IV: comparison of povidone-iodine on the conjunctiva with a prophylactic antibiotic. Arch Ophthalmol. 1985;103:1340–1342
  12. Ta CN, Egbert PR, Singh K, et al. Prospective randomized comparison of 3-day versus 1-hour preoperative ofloxacin prophylaxis for cataract surgery. Ophthalmology. 2002;109:2036–2041
  13. Osher RH, Amdahl LD, Cheetham JK. Antimicrobial efficacy and aqueous humor concentration of preoperative and postoperative topical trimethoprim/polymyxin B sulfate versus tobramycin. J Cataract Refract Surg. 1994;20:3–8
  14. Letter to Physicians. http://www.gene.com/gene/features/avastin/letter-to-physicians.htmlAccessed: December 22, 2007
  15. Kastango ES American Society of Health-System Pharmacists (ASHP). Blueprint for implementing USP Chapter 797 for compounding sterile preparations. Am J Health Syst Pharm. 2005;62:1271–1288

PII: S0002-9394(08)00015-9

doi: 10.1016/j.ajo.2007.12.036

American Journal of Ophthalmology
Volume 145, Issue 5 , Pages 879-882 , May 2008

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