American Journal of Ophthalmology
Volume 145, Issue 6 , Pages 997-1001.e1 , June 2008

The Value of Keratometry and Central Corneal Thickness Measurements in the Clinical Diagnosis of Marfan Syndrome

  • Martin Heur

      Affiliations

    • Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Bryan Costin

      Affiliations

    • Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Sue Crowe

      Affiliations

    • Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Richard A. Grimm

      Affiliations

    • Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Rocio Moran

      Affiliations

    • Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Lars G. Svensson

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.
    • ,
  • Elias I. Traboulsi

      Affiliations

    • Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationInquiries to Elias I. Traboulsi, Cole Eye Institute, 9500 Euclid Ave, i32, Cleveland, OH 44195

,Accepted 24 January 2008.

References 

  1. Dietz HC, Cutting GR, Pyeritz RE, et al. Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature. 1991;352:337–339
  2. Sakai LY, Keene DR, Engvall E. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol. 1986;103:2499–2509
  3. Mir S, Wheatley HM, Hussels IE, Whittum-Hudson JA, Traboulsi EI. A comparative histologic study of the fibrillin microfibrillar system in the lens capsule of normal subjects and subjects with Marfan syndrome. Invest Ophthalmol Vis Sci. 1998;39:84–93
  4. Traboulsi EI, Whittum-Hudson JA, Mir SH, Maumenee IH. Microfibril abnormalities of the lens capsule in patients with Marfan syndrome and ectopia lentis. Ophthalmic Genet. 2000;21:9–15
  5. Wheatley HM, Traboulsi EI, Flowers BE, et al. Immunohistochemical localization of fibrillin in human ocular tissues (Relevance to the Marfan syndrome). Arch Ophthalmol. 1995;113:103–109
  6. De Paepe A, Devereux RB, Dietz HC, Hennekam RC, Pyeritz RE. Revised diagnostic criteria for the Marfan syndrome. Am J Med Genet. 1996;62:417–426
  7. Pyeritz RE, Fishman EK, Bernhardt BA, Siegelman SS. Dural ectasia is a common feature of the Marfan syndrome. Am J Hum Genet. 1988;43:726–732
  8. Maumenee IH. The eye in the Marfan syndrome. Trans Am Ophthalmol Soc. 1981;79:684–733
  9. Hamod A, Moodie D, Clark B, Traboulsi EI. Presenting signs and clinical diagnosis in individuals referred to rule out Marfan syndrome. Ophthalmic Genet. 2003;24:35–39
  10. Sultan G, Baudouin C, Auzerie O, De Saint Jean M, Goldschild M, Pisella PJ. Cornea in Marfan disease: Orbscan and in vivo confocal microscopy analysis. Invest Ophthalmol Vis Sci. 2002;43:1757–1764

PII: S0002-9394(08)00090-1

doi: 10.1016/j.ajo.2008.01.028

American Journal of Ophthalmology
Volume 145, Issue 6 , Pages 997-1001.e1 , June 2008

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