American Journal of Ophthalmology
Volume 146, Issue 1 , Pages 56-59.e2 , July 2008

Evaluation of Intrastromal Injection of Voriconazole as a Therapeutic Adjunctive for the Management of Deep Recalcitrant Fungal Keratitis

  • Gaurav Prakash

      Affiliations

    • Cornea and Refractive Surgery Services, Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Namrata Sharma

      Affiliations

    • Cornea and Refractive Surgery Services, Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Manik Goel

      Affiliations

    • Cornea and Refractive Surgery Services, Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Jeewan S. Titiyal

      Affiliations

    • Cornea and Refractive Surgery Services, Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Rasik B. Vajpayee

      Affiliations

    • Cornea and Refractive Surgery Services, Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    • Center for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
    • Corresponding Author InformationInquiries to Rasik B. Vajpayee, Center for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia

,Accepted 25 February 2008.

References 

  1. Yoon KC, Jeong IY, Im SK, Chae HJ, Yang SY. Therapeutic effect of intracameral amphotericin B injection in the treatment of fungal keratitis. Cornea. 2007;26:814–818
  2. Yilmaz S, Ture M, Maden A. Efficacy of intracameral amphotericin B injection in the management of refractory keratomycosis and endophthalmitis. Cornea. 2007;26:398–402
  3. Kuriakose T, Kothari M, Paul P, Jacob P, Thomas R. Intracameral amphotericin B injection in the management of deep keratomycosis. Cornea. 2002;21:653–656
  4. Ghate D, Edelhauser HF. Ocular drug delivery. Expert Opin Drug Deliv. 2006;3:275–287
  5. Garcia-Valenzuela E, Song CD. Intrastromal injection of amphothericin B for recurrent fungal keratitis and endophthalmitis. Arch Ophthalmol. 2005;123:1721–1723
  6. Freda R. Use of oral voriconazole as adjunctive treatment of severe corneal fungal infection: case report. Arq Bras Oftalmol. 2006;69:431–434
  7. Polizzi A, Sinischalchi C. Effect of voriconazole on a corneal abscess caused by Fusarium. Acta Ophthalmol Scand. 2004;82:762–764
  8. Jhanji V, Sharma N, Mannan R, Titiyal JS, Vajpayee RB. Management of tunnel fungal infection with voriconazole. J Cataract Refract Surg. 2007;33:915–917
  9. Breit SM, Hariprasad SM, Mieler WF, Shah GK, Mills MD, Grand MG. Management of endogenous fungal endophthalmitis with voriconazole and caspofungin. Am J Ophthalmol. 2005;139:135–140
  10. Diekema DJ, Messer SA, Hollis RJ, Jones RN, Pfaller MA. Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi. J Clin Microbiol. 2003;41:3623–3626
  11. Pfaller MA, Messer SA, Hollis RJ, Jones RN, Diekema DJ. In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp. Antimicrob Agents Chemother. 2002;46:1723–1727
  12. Gao H, Pennesi M, Shah K, et al. Safety of intravitreal voriconazole: electroretinographic and histopathologic studies. Trans Am Ophthalmol Soc. 2003;101:183–189

PII: S0002-9394(08)00159-1

doi: 10.1016/j.ajo.2008.02.023

American Journal of Ophthalmology
Volume 146, Issue 1 , Pages 56-59.e2 , July 2008

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