American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 183-192 , August 2008

Evaluation of Autofluorescence Imaging with the Scanning Laser Ophthalmoscope and the Fundus Camera in Age-related Geographic Atrophy

  • Steffen Schmitz-Valckenberg

      Affiliations

    • Department of Ophthalmology, University of Bonn, Bonn, Germany
    • Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom
    • Institute of Ophthalmology, University College London, London, United Kingdom.
    • Corresponding Author InformationInquiries to Steffen Schmitz-Valckenberg, Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, 53127 Bonn, Germany
    • ,
  • Monika Fleckenstein

      Affiliations

    • Department of Ophthalmology, University of Bonn, Bonn, Germany
    • ,
  • Arno P. Göbel

      Affiliations

    • Department of Ophthalmology, University of Bonn, Bonn, Germany
    • ,
  • Kulwant Sehmi

      Affiliations

    • Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom
    • ,
  • Frederick W. Fitzke

      Affiliations

    • Institute of Ophthalmology, University College London, London, United Kingdom.
    • ,
  • Frank G. Holz

      Affiliations

    • Department of Ophthalmology, University of Bonn, Bonn, Germany
    • ,
  • Adnan Tufail

      Affiliations

    • Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom

,Accepted 2 April 2008.

References 

  1. Blair CJ. Geographic atrophy of the retinal pigment epithelium (A manifestation of senile macular degeneration). Arch Ophthalmol. 1975;93:19–25
  2. Sunness JS. The natural history of geographic atrophy, the advanced atrophic form of age-related macular degeneration. Mol Vis. 1999;5:25
  3. Maguire P, Vine AK. Geographic atrophy of the retinal pigment epithelium. Am J Ophthalmol. 1986;102:621–625
  4. Schatz H, McDonald HR. Atrophic macular degeneration (Rate of spread of geographic atrophy and visual loss). Ophthalmology. 1989;96:1541–1551
  5. Klein R, Klein BE, Knudtson MD, et al. Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology. 2007;114:253–262
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  9. Von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;79:407–412
  10. Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718–729
  11. Holz FG, Schmitz-Valckenberg S, Spaide RF, Bird AC. Atlas of fundus autofluorescence imaging. In: Berlin, Germany: Springer; 2007;p. 49–53
  12. Deckert A, Schmitz-Valckenberg S, Jorzik J, et al. Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO). BMC Ophthalmol. 2005;5:8
  13. Schmitz-Valckenberg S, Jorzik J, Unnebrink K, Holz FG. Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2002;240:73–78
  14. Holz FG, Bellmann C, Margaritidis M, et al. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 1999;237:145–152
  15. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42:1051–1056
  16. Schmitz-Valckenberg S, Bindewald-Wittich A, Dolar-Szczasny J, et al. Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci. 2006;47:2648–2654
  17. Holz FG, Bindewald-Wittich A, Fleckenstein M, et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463–472
  18. Spaide RF. Fundus autofluorescence and age-related macular degeneration. Ophthalmology. 2003;110:392–399
  19. The Age-Related Eye Disease Study (AREDS) system for classifying cataracts from photographs (AREDS Report No. 4). Am J Ophthalmol. 2001;131:167–175
  20. Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res. 1999;8:135–160
  21. Bindewald A, Schmitz-Valckenberg S, Jorzik JJ, et al. Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Br J Ophthalmol. 2005;89:874–878
  22. Schweitzer D, Schenke S, Hammer M, et al. Towards metabolic mapping of the human retina. Microsc Res Tech. 2007;70:410–419

PII: S0002-9394(08)00275-4

doi: 10.1016/j.ajo.2008.04.006

American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 183-192 , August 2008

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