American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 260-265.e1 , August 2008

Antifungal Susceptibility for Common Pathogens of Fungal Keratitis in Shandong Province, China

  • Lixin Xie

      Affiliations

    • State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
    • Corresponding Author InformationInquiries to Lixin Xie, Shandong Eye Institute, 5 Yanerdao Road, Qingdao 266071, China
  • ,
  • Hualei Zhai

      Affiliations

    • State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
    • Medical College of Qingdao University, Qingdao, China.
  • ,
  • Jing Zhao

      Affiliations

    • State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
  • ,
  • Shiying Sun

      Affiliations

    • State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
  • ,
  • Weiyun Shi

      Affiliations

    • State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
  • ,
  • Xiaoguang Dong

      Affiliations

    • State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China

,Accepted 10 April 2008.

References 

  1. Srinivasan M. Fungal keratitis. Curr Opin Ophthalmol. 2004;15:321–327
  2. Xie L, Zhai H, Shi W. Penetrating keratoplasty for corneal perforations in fungal keratitis. Cornea. 2007;26:158–162
  3. Xie L, Dong X, Shi W. Treatment of fungal keratitis by penetrating keratoplasty. Br J Ophthalmol. 2001;85:1070–1074
  4. Xie L, Shi W, Liu Z, Li S. Lamellar keratoplasty for the treatment of fungal keratitis. Cornea. 2002;21:33–37
  5. Sun X, Wang Z, Luo S, et al. Etiological analysis on the ocular fungal infection (in Chinese). Zhonghua Yan Ke Za Zhi. 2002;38:405–407
  6. He Y, Sun B, Zhao D, Wang Y, Li J, Zhu L. The clinical features and study on therapeutic effects of fungal keratitis (in Chinese). Zhonghua Yan Ke Za Zhi. 2000;36:358–361
  7. Xie L, Shi W, Dong X, Wang Z, Liu J, Wang J. Clinical and histopathological study of fungal keratitis in 108 cases (in Chinese). Yan Ke Yan Jiu. 1999;17:283–285
  8. Wu S. Laboratory handbook of modern medical mycology. Beijing, China: Publishing House of Peking Medical University and Chinese Union Medical University; 1998;104—295
  9. Srinivasan M, Gonzales CA, George C, et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, South India. Br J Ophthalmol. 1997;81:965–971
  10. Leck AK, Thomas PA, Hagan M, et al. Aetiology of suppurative corneal ulcers in Ghana and South India, and epidemiology of fungal keratitis. Br J Ophthalmol. 2002;86:1211–1215
  11. Dursun D, Fernandez V, Miller D, Alfonso EC. Advanced fusarium keratitis progressing to endophthalmitis. Cornea. 2003;22:300–303
  12. Rosa RH, Miller D, Alfonso EC. The changing spectrum of fungal keratitis in South Florida. Ophthalmology. 1994;101:1005–1013
  13. Upadhyay MP, Karmacharya PC, Koirala S, et al. Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal. Am J Ophthalmol. 1991;111:92–99
  14. Xie L, Zhong W, Shi W, Sun S. Spectrum of fungal keratitis in North China. Ophthalmology. 2006;113:1943–1948
  15. National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard. NCCLS: Wayne, Pennsylvania 2002:1–30.
  16. Kon T, Nemoto N, Oshima T, Yamagishi A. Effects of a squalene epoxidase inhibitor, terbinafine, on ether lipid biosyntheses in a thermoacidophilic archaeon, Thermoplasma acidophilum. J Bacteriol. 2002;184:1395–1401
  17. Sun XG, Wang ZX, Wang ZQ, et al. Pharmacokinetics of terbinafine in the rabbit ocular tissues after topical administration. Ophthalmic Res. 2007;39:81–83
  18. Liu H, Wang X, Zhou Y, Peng S. Pharmarcokinetics of terbinafine eye drops in rabbits aqueous and cornea (in Chinese). Yan Ke Yan Jiu. 2006;24:15–17
  19. Sun X, Wang Z, Li R, et al. Distribution of terbinafine in ocular tissues after topical administration to albino rabbits (in Chinese). Yan Ke. 2002;11:235–237
  20. Wang P, Liu J, Lu L. Experimental and clinical study of terbinafine in the treatment of fungal keratitis (in Chinese). Zhongguo Shi Yong Yan Ke Za Zhi. 2003;21:910–912
  21. Cheng H, Dou Y, Shao H. A clinical analysis of fungal corneal ulcer treated by terbinafine and diflucan (in Chinese). J Preclin Med Coll Shandong Univ. 2002;16:297–298
  22. Marangon FB, Miller D, Giaconi JA, et al. In vitro investigation of voriconazole susceptibility for keratitis and endophthalmitis fungal pathogens. Am J Ophthalmol. 2004;137:820–825
  23. Ozbek Z, Kang S, Sivalingam J, et al. Voriconazole in the management of Alternaria keratitis. Cornea. 2006;25:242–244
  24. Sponsel WE, Graybill JR, Nevarez HL, et al. Ocular and systemic posaconazole (SCH-56592) treatment of invasive Fusarium solani keratitis and endophthalmitis. Br J Ophthalmol. 2002;86:829–830
  25. Goldblum D, Frueh BE, Sarra GM, et al. Topical caspofungin for treatment of keratitis caused by Candida albicans in a rabbit model. Antimicrob Agents Chemother. 2005;49:1359–1363
  26. Lalitha P, Shapiro BL, Srinivasan M, et al. Antimicrobial susceptibility of Fusarium, Aspergillus, and other filamentous fungi isolated from keratitis. Arch Ophthalmol. 2007;125:789–793
  27. Galarreta DJ, Tuft SJ, Ramsay A, Dart JK. Fungal keratitis in London: microbiological and clinical evaluation. Cornea. 2007;26:1082–1086
  28. Sun XG, Zhang Y, Li R, et al. Etiological analysis on ocular fungal infection in the period of 1989–2000. Chin Med J (Engl). 2004;117:598–600
  29. Wang L, Zhang Y, Wang Y, et al. Spectrum of mycotic keratitis in China (in Chinese). Zhonghua Yan Ke Za Zhi. 2000;36:138–140
  30. Sun X, Wang Z, Wang Z, Luo S, Li R. Ocular fungal isolates and antifungal susceptibility in Northern China. Am J Ophthalmol. 2007;143:131–133
  31. Hospenthal DR, Murray CK, Rinaldi MG. The role of antifungal susceptibility testing in the therapy of eandidiasis. Diagn Mierobiol Infect Dis. 2004;48:153–160
  32. Rex JH, Pfaler MA. Has antifungal susceptibility testing come of age?. Clin Infect Dis. 2002;35:982–989

PII: S0002-9394(08)00301-2

doi: 10.1016/j.ajo.2008.04.019

American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 260-265.e1 , August 2008