American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 154-155 , August 2008

Surgical Treatment of Limbal Stem Cell Deficiency: Are We Really Transplanting Stem Cells?

  • Shigeto Shimmura
    • ,
  • Kazuo Tsubota

      Affiliations

    • Corresponding Author InformationInquiries to Kazuo Tsubota, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

,Accepted 14 April 2008.

References 

  1. Yoshida S, Shimmura S, Kawakita T, et al. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci. 2006;47:4780–4786
  2. Cauchi PA, Ang GS, Azuara-Blanco A, Burr JM. A systematic literature review of surgical interventions for limbal stem cell deficiency in humans. Am J Ophthalmol. 2008;146:251–259
  3. Reinhard T, Spelsberg H, Henke L, et al. Long-term results of allogeneic penetrating limbo-keratoplasty in total limbal stem cell deficiency. Ophthalmology. 2004;111:775–782
  4. Tsubota K, Satake Y, Kaido M, et al. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. N Engl J Med. 1999;340:1697–1703
  5. Yao YF, Zhang B, Zhou P, Jiang JK. Autologous limbal grafting combined with deep lamellar keratoplasty in unilateral eye with severe chemical or thermal burn at late stage. Ophthalmology. 2002;109:2011–2017
  6. Shimazaki J, Shimmura S, Ishioka M, Tsubota K. Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty. Am J Ophthalmol. 2002;134:159–165
  7. Shimazaki J, Shimmura S, Tsubota K. Donor source affects the outcome of ocular surface reconstruction in chemical or thermal burns of the cornea. Ophthalmology. 2004;111:38–44
  8. Rama P, Bonini S, Lambiase A, et al. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency. Transplantation. 2001;72:1478–1485
  9. Tsai RJ, Li LM, Chen JK. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Engl J Med. 2000;343:86–93
  10. Shimazaki J, Kaido M, Shinozaki N, et al. Evidence of long-term survival of donor-derived cells after limbal allograft transplantation. Invest Ophthalmol Vis Sci. 1999;40:1664–1668
  11. Nishida K, Yamato M, Hayashida Y, et al. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med. 2004;351:1187–1196

 See accompanying Article on page 251.

PII: S0002-9394(08)00309-7

doi: 10.1016/j.ajo.2008.04.025

American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 154-155 , August 2008

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