American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 218-227.e1 , August 2008

The Role of Abnormal Vitreomacular Adhesion in Age-related Macular Degeneration: Spectral Optical Coherence Tomography and Surgical Results

  • Francesca Mojana

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
  • ,
  • Lingyun Cheng

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
  • ,
  • Dirk-Uwe G. Bartsch

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
  • ,
  • Gabriel A. Silva

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
    • Department of Bioengineering, University of California San Diego, La Jolla, California.
  • ,
  • Igor Kozak

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
  • ,
  • Nitin Nigam

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
  • ,
  • William R. Freeman

      Affiliations

    • Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California
    • Corresponding Author InformationInquiries to William R. Freeman, University of California San Diego Department of Ophthalmology, Shiley Eye Center, 0946, Joan and Irwin Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA 92037

,Accepted 15 April 2008.

References 

  1. La Cour M, Kiilgaard JF, Nissen MH. Age-related macular degeneration: epidemiology and optimal treatment. Drugs Aging. 2002;19:101–133
  2. Congdon N, O'Colmain B, Klaver CC, et al. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol. 2004;122:477–485
  3. Klein R, Klein BE, Lee KE, Cruickshanks KJ, Gangnon RE. Changes in visual acuity in a population over a 15-year period: the Beaver Dam Eye Study. Am J Ophthalmol. 2006;142:539–549
  4. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385–389
  5. Dewan A, Liu M, Hartman S, et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006;314:989–992
  6. Mori K, Horie-Inoue K, Kohda M, et al. Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population. J Hum Genet. 2007;52:636–641
  7. Nussenblatt RB, Ferris F. Age-related macular degeneration and the immune response: implications for therapy. Am J Ophthalmol. 2007;144:618–626
  8. Lambert HM, Capone A, Aaberg TM, et al. Surgical excision of subfoveal neovascular membranes in age-related macular degeneration. Am J Ophthalmol. 1992;113:257–262
  9. Weber-Krause B, Eckardt U. [Incidence of posterior vitreous detachment in eyes with and without age-related macular degeneration. An ultrasonic study]. Ophthalmologe. 1996;93:660–665
  10. Ondes F, Yilmaz G, Acar MA, Unlu N, Kocaoglan H, Arsan AK. Role of the vitreous in age-related macular degeneration. Jpn J Ophthalmol. 2000;44:91–93
  11. Krebs I, Brannath W, Glittenberg C, Zeiler F, Sebag J, Binder S. Posterior Vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?. Am J Ophthalmol. 2007;144:741–746
  12. Wojtkowski M, Leitgeb R, Kowalczyk A, Bajraszewski T, Fercher AF. In vivo human retinal imaging by Fourier-domain optical coherence tomography. J Biomed Opt. 2002;7:457–463
  13. De Boer JF, Cense B, Park BH, Pierce MC, Tearney GJ, Bouma BE. Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Optics Letters. 2003;28:2067–2069
  14. Schmidt-Erfurth U, Leitgeb RA, Michels S, et al. Three-dimensional ultra-high-resolution optical coherence tomography of macular diseases. Invest Ophthalmol Vis Sci. 2005;46:3393–3402
  15. Srinivasan VJ, Wojtkowski M, Witkin AJ, et al. High-definition and 3-dimensional imaging of macular pathologies with high-speed ultra-high-resolution optical coherence tomography. Ophthalmology. 2006;113:2054;e1–14
  16. Kakehashi A, Kado M, Akiba J, Hirokawa H. Variations of posterior vitreous detachment. Br J Ophthalmol. 1997;81:527–532
  17. Uchino E, Uemura A, Ohba N. Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography. Arch Ophthalmol. 2001;119:1475–1479
  18. Johnson MW. Perifoveal vitreous detachment and its macular complications. Trans Am Ophthalmol Soc. 2005;103:537–567
  19. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13–22
  20. Lipsitz SH, Kim K, Zhao L. Analysis of repeated categorical data using generalized estimating equations. Statistics in Medicine. 1994;13:1149–1163
  21. Quaranta-El Maftouhi M, Mauget-Faysse M. Anomalous vitreoretinal adhesions in patients with exudative age-related macular degeneration: an OCT study. Eur J Ophthalmol. 2006;16:134–137
  22. Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 2002;134:411–431
  23. Donoso LA, Kim D, Frost A, Callahan A, Hageman G. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2006;51:137–152
  24. Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004;122:598–614
  25. Johnson PT, Lewis GP, Talaga KC, et al. Drusen-associated degeneration in the retina. Invest Ophthalmol Vis Sci. 2003;44:4481–4488
  26. Wu KH, Madigan MC, Billson FA, Penfold PL. Differential expression of GFAP in early vs late AMD: a quantitative analysis. Br J Ophthalmol. 2003;87:1159–1166
  27. Ramirez JM, Ramirez AI, Salazar JJ, de Hoz R, Trivino A. Changes of astrocytes in retinal aging and age-related macular degeneration. Exp Eye Res. 2001;73:601–615
  28. Petrukhin K. New therapeutic targets in atrophic age-related macular degeneration. Expert Opin Ther Targets. 2007;11:625–639
  29. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997;104:7–21
  30. Van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, de Jong PT. The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam Study. Arch Ophthalmol. 2003;121:519–526
  31. Schubert HD. Cystoid macular edema: the apparent role of mechanical factors. Prog Clin Biol Res. 1989;312:277–291
  32. Freeman WR, Falkenstein I. Avastin and new treatments for AMD: where are we?. Retina. 2006;26:853–858
  33. Chu TG, Lopez PF, Cano MR, et al. Posterior vitreoschisis (An echographic finding in proliferative diabetic retinopathy). Ophthalmology. 1996;103:315–322

PII: S0002-9394(08)00311-5

doi: 10.1016/j.ajo.2008.04.027

American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 218-227.e1 , August 2008