American Journal of Ophthalmology
Volume 146, Issue 3 , Pages 375-384.e4 , September 2008

Longitudinal Study of New Eye Lesions in Children with Toxoplasmosis Who Were Not Treated During the First Year of Life

  • Laura Phan

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Kristen Kasza

      Affiliations

    • Department of Health Studies, University of Chicago, Chicago, Illinois
    • ,
  • Jessica Jalbrzikowski

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • A. Gwendolyn Noble

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • Paul Latkany

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • St Luke's–Roosevelt Hospital, New York Eye and Ear Infirmary, New York, New York
    • ,
  • Annie Kuo

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • William Mieler

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Sanford Meyers

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Peter Rabiah

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Kenneth Boyer

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Rush University Medical Center, Chicago, Illinois
    • ,
  • Charles Swisher

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • Marilyn Mets

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • Nancy Roizen

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Cleveland Clinic, Cleveland, Ohio
    • ,
  • Simone Cezar

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Mari Sautter

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Jack Remington

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Palo Alto Medical Foundation, Stanford University, Palo Alto, California
    • ,
  • Paul Meier

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Columbia University, New York, New York
    • ,
  • Rima Mcleod

      Affiliations

    • University of Chicago School of Medicine, University of Chicago, Chicago, Illinois
    • Corresponding Author InformationInquiries to Rima McLeod, University of Chicago, MBH 206, 5841 South Maryland Ave, Chicago, IL 60637
    • ,
  • Toxoplasmosis Study Group

,Accepted 23 April 2008.

References 

  1. Koppe JG, Loewer-Sieger DH, de Roever-Bonnet H. Results of 20-year follow-up of congenital toxoplasmosis. Lancet. 1986;1:254–256
  2. Wilson CB, Remington JS, Stagno S, Reynolds DW. Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection. Pediatrics. 1980;66:767–774
  3. Mets MB, Holfels E, Boyer KM, et al. Eye manifestations of congenital toxoplasmosis. Am J Ophthalmol. 1996;122:309–324
  4. McAuley J, Boyer KM, Patel D, et al. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis. 1994;18:38–72
  5. Roizen N, Swisher CN, Stein MA, et al. Neurologic and developmental outcome in treated congenital toxoplasmosis. Pediatrics. 1995;95:11–20
  6. McLeod R, Boyer K, Karrison T, et al. Outcome of treatment for congenital toxoplasmosis, 1981–2004: the National Collaborative Chicago-Based Congenital Toxoplasmosis Study. Clin Infect Dis. 2006;42:1383–1394
  7. Hogan MJ. Ocular toxoplasmosis. Am J Ophthalmol. 1958;46:467–494
  8. Phan L, Kasza K, Jalbrzikowski J, et al. Longitudinal study of new eye lesions in treated congenital toxoplasmosis. Ophthalmology. 2008;115:553–559
  9. Binquet C, Wallon M, Quantin C, et al. Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosis. Epidemiol Infect. 2003;131:1157–1168
  10. Couvreur J, Desmonts G, Tournier G, Szusterkac M. A homogeneous series of 210 cases of congenital toxoplasmosis in 0 to 11-month-old infants detected prospectively. [in French] Ann Pediatr (Paris). 1984;31:815–819
  11. Desmonts G, Couvreur J. Congenital toxoplasmosis (Prospective study of the outcome of pregnancy in 542 women with toxoplasmosis acquired during pregnancy). [in French] Ann Pediatr (Paris). 1984;31:805–809
  12. Silveira C, Belfort R, Muccioli C, et al. The effect of long-term intermittent trimethoprim/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditis. Am J Ophthalmol. 2002;134:41–46

 Supplemental Material available at AJO.com.

PII: S0002-9394(08)00335-8

doi: 10.1016/j.ajo.2008.04.033

American Journal of Ophthalmology
Volume 146, Issue 3 , Pages 375-384.e4 , September 2008

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